LEADER 03349nam 2200697 a 450 001 9910451858303321 005 20211005024246.0 010 $a0-8147-9081-X 010 $a0-8147-3725-0 035 $a(CKB)1000000000484142 035 $a(EBL)2081660 035 $a(OCoLC)913695179 035 $a(SSID)ssj0000189674 035 $a(PQKBManifestationID)11168156 035 $a(PQKBTitleCode)TC0000189674 035 $a(PQKBWorkID)10156688 035 $a(PQKB)11079155 035 $a(MiAaPQ)EBC2081660 035 $a(Au-PeEL)EBL2081660 035 $a(CaPaEBR)ebr10211744 035 $a(MiAaPQ)EBC3025605 035 $a(Au-PeEL)EBL3025605 035 $a(EXLCZ)991000000000484142 100 $a20011214d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aLatino/a popular culture$b[electronic resource] /$fedited by Michelle Habell-Pall?an and Mary Romero 210 $aNew York $cNew York University Press$dc2002 215 $a1 online resource (280 p.) 300 $aDescription based upon print version of record. 311 $a0-8147-3624-6 311 $a0-8147-3625-4 320 $aIncludes bibliographical references and index. 327 $a""Bidi Bidi Bom Bom Selena and Tejano Music in the Making of Tejas""""Hip Hop and New York Puerto Ricans""; ""THEATER AND ART""; ""Paul Simona???s The CapemanThe Staging of Puerto Rican National Identity as Spectacle and Commodity on Broadway""; ""Gender Bending in Latino Theater Johnny Diego,The His-panic Zone, and Deporting the Divasby Guillermo Reyes""; ""a???Dona???t Call Us Hispanica??? Popular Latino Theater in Vancouver""; ""A Decidedly a???Mexicana??? and a???Americana??? Semi[er]otic Transference Frida Kahlo in the Eyes of Gilbert Hernandez"" 330 $aCover artwork by Diane Gamboa. Credit-Click here Latinos have become the largest ethnic minority group in the United States. While the presence of Latinos and Latinas in mainstream news and in popular culture in the United States buttresses the much-heralded Latin Explosion, the images themselves are often contradictory. In Latino/a Popular Culture, Habell-Palla?n and Romero have brought together scholars from the humanities and social sciences to analyze representations of Latinidad in a diversity of genres - media, culture, music, film, theatre, art, and sports - that are emerging acro 606 $aHispanic Americans$xEthnic identity 606 $aHispanic Americans and mass media 606 $aPopular culture$zUnited States 606 $aHispanic Americans$xSocial life and customs 606 $aHispanic American arts 606 $aHispanic American athletes 608 $aElectronic books. 615 0$aHispanic Americans$xEthnic identity. 615 0$aHispanic Americans and mass media. 615 0$aPopular culture 615 0$aHispanic Americans$xSocial life and customs. 615 0$aHispanic American arts. 615 0$aHispanic American athletes. 676 $a305.868/073 701 $aHabell-Palla?n$b Michelle$01037181 701 $aRomero$b Mary$0750882 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451858303321 996 $aLatino$92457962 997 $aUNINA LEADER 05035nam 2200661Ia 450 001 9910143988603321 005 20190813180146.0 010 $a1-282-30842-4 010 $a9786612308420 010 $a0-470-12580-2 010 $a0-470-12607-8 035 $a(CKB)1000000000376101 035 $a(EBL)468830 035 $a(OCoLC)609847558 035 $a(SSID)ssj0000308378 035 $a(PQKBManifestationID)11244365 035 $a(PQKBTitleCode)TC0000308378 035 $a(PQKBWorkID)10251830 035 $a(PQKB)10177675 035 $a(MiAaPQ)EBC468830 035 $a(EXLCZ)991000000000376101 100 $a19920731d1992 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aReviews in computational chemistry III /$fedited by Kenny B. Lipkowitz and Donald B. Boyd 210 $aNew York, NY $cVCH$dc1992 215 $a1 online resource (290 p.) 225 0 $aReviews in computational chemistry ;$v3 300 $aDescription based upon print version of record. 311 $a0-471-18853-0 320 $aIncludes bibliographical references and indexes. 327 $aReviews in Computational Chemistry 111; Contents; Optimization Methods in Computational Chemistry; Introduction; Mathematical Preliminaries; Notation; Problem Statement; Matrix Characteristics; Conditions at Minima; Analysis of Functions; Basic Approaches to Large-Scale Optimization; Size and Space Limitations; Search Techniques; Local and Global Methods; Basic Descent Structure of Local Methods; Descent Directions; Line Search and Trust Region Steps; Convergence Criteria; Convergence Characterization; Nonderivative Methods; Gradient Methods; Steepest Descent; Conjugate Gradient 327 $aPreconditioningNonlinear Conjugate Gradient; Newton Methods; Overview; Discrete Newton; Quasi-Newton; Truncated Newton; Perspective and Computational Examples; Comparisons; Numerical Example I: Rosenbrock Minimization; Numerical Example II: Deoxycytidine; Numerical Example III: Water Clusters; New Technologies; Acknowledgments; References; Predicting Three-Dimensional Structures of Oligopeptides; Introduction; Theoretical Foundations; Generation of Oligopeptide Chain; Residue Geometry; End-Group Geometry; Constructing a Molecule; Ring Closure without Symmetry; Ring Closure with Symmetry 327 $aEarly Use of Hard-Sphere PotentialMore Realistic Potentials; Potential Functions; Optimization Methods; Ancillary Techniques; Application to Simple Systems; Multiple-Minima Problem; Build-up Methods; Optimization of Electrostatics (Self-consistent Electric Field); Monte Carlo plus Minimization; Electrostatically Driven Monte Carlo; Adaptive Importance Sampling Monte Carlo; Increase in Dimensionality; Deformation of the Potential Energy Hypersurface; Mean-Field Theory; Simulated Annealing; Extension of Methodology to Large Polypeptides and Proteins; Build-up Method 327 $aBuild-up with Limited ConstraintsCalculations with Constraints; Use of Homology; Pattern-Recognition Importance Sampling Minimization (PRISM); Outlook for the Future; Acknowledgments; References; Molecular Modeling Using Nuclear Magnetic Resonance Data; Introduction; Scope and Definitions; Historical Perspective; Molecular Representation; Generating Initial Structures; Metric Matrix Method; Variable Target Function Method; Other Methods for Generating Initial Structures; Modeling of Experimental Data; Distance Restraints; Averaging over Discrete Conformations 327 $aTime-Averaged Distance RestraintsDirect NOE Refinement; Dihedral Angle Restraints; Refinement, Minimization, and Dynamics; Molecular Dynamics; Other Derivative-Based Dynamics Schemes; Other Non-Derivative-Based Schemes; Force Field; Force Field Parameters and Accuracy; Force Field Modifications; Systematic Errors and Biases; Quality of Structures; Future Directions; Acknowledgment; References; Computer-Assisted Methods in the Evaluation of Chemical Toxicity; Introduction; Computer-Based Methods for Toxicity Evaluation; Quantitative Structure-Activity Relationship 327 $aPattern Recognition Techniques 330 $aFrom reviews of the series:'Many of the articles are indeed accessible to any interested nonspecialist, even without theoretical background.'Journal of the American Chemical Society'...an invaluable resource for the serious molecular modeler.' Chemical Design Automation News 410 0$aReviews in Computational Chemistry 606 $aChemistry$xData processing 606 $aChemistry$xMathematics 608 $aElectronic books. 615 0$aChemistry$xData processing. 615 0$aChemistry$xMathematics. 676 $a542.85 676 $a542/.8 701 $aLipkowitz$b Kenny B$0855564 701 $aBoyd$b Donald B$0855565 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143988603321 996 $aReviews in computational chemistry III$91978113 997 $aUNINA LEADER 04441nam 2200349 450 001 9910598175403321 005 20230328221839.0 035 $a(CKB)3710000000657029 035 $a(NjHacI)993710000000657029 035 $a(EXLCZ)993710000000657029 100 $a20230328d2015 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aIPS Cells for Modelling and Treatment of Human Diseases /$fedited by Michael J. Edel 210 1$aBasel :$cMDPI - Multidisciplinary Digital Publishing Institute,$d2015. 215 $a1 online resource (422 pages) $cillustrations 311 $a3-03842-122-7 327 $aList of Contributors -- About the Guest Editor -- Preface -- Chapter 1: Neuronal -- Opportunities and Limitations of Modelling Alzheimer's Disease with Induced Pluripotent Stem Cells -- Induced Pluripotent Stem Cells Derived from Alzheimer's Disease Patients: The Promise, the Hope and the Path Ahead -- iPSC-based Models to Unravel Key Pathogenetic Processes underlying Motor Neuron Diseases Development -- Chapter 2: Cardiac -- Bioengineering and Stem Cell Technology in the Treatment of Congenital Heart Disease -- Scalable Electrophysiological Investigation of iPS Cell Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy -- Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells -- Chapter 3: Eye -- iPS Cells for Modelling and Treatment of Retinal Diseases -- Patient-Specific iPSC-Derived RPE for Modeling of Retinal Diseases -- Potential role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface -- Chapter 4: Spinal Cord Injury -- The Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and Challenges -- The State of Play with iPSCs and Spinal Cord Injury Models -- Chapter 5: Liver -- Potential and Challenges of Induced Pluripotent Stem Cells in Liver Diseases Treatment -- Chapter 6: Muscle -- Myogenic Precursors from iPS Cells for Skeletal Muscle Cell Replacement Therapy -- Chapter 7: Bone -- The Use of Patient-Specific Induced Pluripotent Stem Cells (iPSCs) to Identify Osteoclast Defects in Rare Genetic Bone Disorders -- Chapter 8: Germ Cells -- Human iPS Cell-derived Germ Cells: Current Status and Clinical Potential -- Chapter 9: Genetic Disorders -- Comparing ESC and iPSC-Based Models for Human Genetic Disorders -- Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products -- Concise Review: Methods and Cell Types Used to Generate Down Syndrome Induced Pluripotent Stem Cells -- Chapter 10: Immune Response -- The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases. 330 $aThe field of reprogramming somatic cells into induced pluripotent stem cells (iPSC) has moved very quickly, from bench to bedside in just eight years since its first discovery. The best example of this is the RIKEN clinical trial this year in Japan, which will use iPSC derived retinal pigmented epithelial (RPE) cells to treat macular degeneration (MD). This is the first human disease to be tested for regeneration and repair by iPSC-derived cells and others will follow in the near future. Currently, there is an intense worldwide research effort to bring stem cell technology to the clinic for application to treat human diseases and pathologies. Human tissue diseases (including those of the lung, heart, brain, spinal cord, and muscles) drive organ bioengineering to the forefront of technology concerning cell replacement therapy. Given the critical mass of research and translational work being performed, iPSCs may very well be the cell type of choice for regenerative medicine in the future. Also, basic science questions, such as efficient differentiation protocols to the correct cell type for regenerating human tissues, the immune response of iPSC replacement therapy and genetic stability of iPSC-derived cells, are currently being investigated for future clinical applications. 606 $aGenetic transcription 615 0$aGenetic transcription. 676 $a572.8845 702 $aEdel$b Michael J. 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910598175403321 996 $aIPS Cells for Modelling and Treatment of Human Diseases$92948906 997 $aUNINA