LEADER 04724nam 22006854a 450 001 9910143986903321 005 20170809163212.0 010 $a1-281-78802-3 010 $a9786611788025 010 $a0-470-38638-X 010 $a0-470-38637-1 035 $a(CKB)1000000000540925 035 $a(EBL)468844 035 $a(OCoLC)264703252 035 $a(SSID)ssj0000176955 035 $a(PQKBManifestationID)11153821 035 $a(PQKBTitleCode)TC0000176955 035 $a(PQKBWorkID)10210759 035 $a(PQKB)11071722 035 $a(MiAaPQ)EBC468844 035 $a(PPN)242640702 035 $a(EXLCZ)991000000000540925 100 $a20080402d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aImmunotoxicology strategies for pharmaceutical safety assessment$b[electronic resource] /$fedited by Danuta J. Herzyk and Jeanine L. Bussiere 210 $aHoboken, N.J. $cWiley$dc2008 215 $a1 online resource (432 p.) 300 $aDescription based upon print version of record. 311 $a0-470-12238-2 320 $aIncludes bibliographical references and index. 327 $aCurrent regulatory expectations for immunotoxicologyy evaluation of pharmaceuticals / Kenneth L. Hastings -- Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans -- Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley -- 327 $aNeed for specialized immunotoxicity tests / Kazuichi Nakamura -- Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj -- T cell-dependent antibody response tests / Joseph R. Piccotti -- Natural killer cell assay and other innate immunity tests / Lisa Plitnick -- Cellular immune response in delayed-type hypersensitivity test / Karen Price -- Evaluation of drug effects on immune cell phenotypes / Laurie Iciek -- 327 $aFunctional cellular responses and cytokine profiles / Elizabeth R. Gore -- Application of flow cytometry in drug development / Padma Narayanan ... [et al.] -- Animal models of host resistance / Gary R. Burleson and Florence G. Burleson -- Approaches to evaluation of autoimmunity / Danuta J. Herzyk -- 327 $aDifferentiating between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho -- Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere -- Antidrug antibody responses in nonclinical studies and their implications / Barbara Mounho -- Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House -- 327 $aImmunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski ... [et al.] -- Systemic hypersensitivity / Raymond Pieters -- Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier -- Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas -- Developmental immunotoxicity in nonhuman primates / Pauline L. Martin and Eberhard Buse -- 327 $aAlternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski -- Animal models for preclinical comparative immunogenicity testing / Daniel Wierda -- T cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer -- Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes. 330 $aAn important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidatesHelps readers understand the significance of the methods and approaches to immunotoxicology testingAids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testingOffers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune systemIncludes chapter authors from across the ph 606 $aImmunotoxicology 606 $aImmune system$xEffect of drugs on 606 $aToxicity testing 606 $aDrugs$xToxicology 615 0$aImmunotoxicology. 615 0$aImmune system$xEffect of drugs on. 615 0$aToxicity testing. 615 0$aDrugs$xToxicology. 676 $a615.19 676 $a616.97/071 701 $aHerzyk$b Danuta J$0932391 701 $aBussiere$b Jeanine L$0932392 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143986903321 996 $aImmunotoxicology strategies for pharmaceutical safety assessment$92098115 997 $aUNINA