LEADER 05246nam 22006134a 450 001 9910143744803321 005 20170815121436.0 010 $a1-280-44877-6 010 $a9786610448777 010 $a0-470-02261-2 010 $a0-470-02259-0 035 $a(CKB)1000000000357217 035 $a(EBL)257680 035 $a(OCoLC)71432738 035 $a(SSID)ssj0000159433 035 $a(PQKBManifestationID)11164528 035 $a(PQKBTitleCode)TC0000159433 035 $a(PQKBWorkID)10158063 035 $a(PQKB)10029560 035 $a(MiAaPQ)EBC257680 035 $a(EXLCZ)991000000000357217 100 $a20050606d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFrontiers in crystal engineering$b[electronic resource] /$fedited by Edward R.T. Tiekink, Jagadese J. Vittal 210 $aChichester, England ;$aHoboken, NJ $cWiley$dc2006 215 $a1 online resource (347 p.) 300 $aDescription based upon print version of record. 311 $a0-470-02258-2 320 $aIncludes bibliographical references and index. 327 $aFrontiers in Crystal Engineering; Contents; List of Contributors; Foreword; 1 Applications of Crystal Engineering Strategies in Solvent-free Reactions: Toward a Supramolecular Green Chemistry; 1 Introduction; 1.1 Making Crystals by Smashing Crystals?; 1.2 Milling, Grinding, Kneading and Seeding; 2 Mechanochemical Preparation of Hydrogen-Bonded Adducts; 3 Mechanically Induced Formation of Covalent Bonds; 3.1 Mechanochemical Preparation of Coordination Networks; 4 The Solvent-free Chemistry of the Zwitterion [CoIII(?5-C5H4COOH)(?5-C5H4COO)]; 5 Concluding Remarks; 6 Acknowledgments; References 327 $a2 Crystal Engineering of Pharmaceutical Co-crystals1 Introduction; 1.1 What Are Co-crystals?; 1.2 How Are Co-crystals Prepared?; 1.3 Why Are Co-crystals of Relevance in the Context of APIs?; 2 What Is the Origin of Polymorphism and Is It Prevalent in Co-crystals?; 3 What Is a Pharmaceutical Co-crystal?; 3.1 A Case Study: Pharmaceutical Co-crystals of Carbamazepine, 1 (CBZ, 1); 3.2 But Beware of "Fake" Pharmaceutical Co-crystals!; 4 Conclusions; 5 Acknowledgments; References; 3 Template-controlled Solid-state Synthesis: Toward a General Form of Covalent Capture in Molecular Solids 327 $a1 Introduction1.1 Target-oriented Organic Synthesis; 1.2 Target-oriented Organic Synthesis and Covalent Capture; 1.3 Overview; 2 Controlling Reactivity Using Linear Templates; 3 Template-controlled Solid-state Reactivity; 3.1 Template-controlled Reactivity in the Solid state; 3.2 Resorcinol as a Linear Template; 3.3 Modularity and Generality; 4 Target-oriented Organic Synthesis in the Solid State; 4.1 [2.2]-Paracyclophane; 4.2 Template Switching; 4.3 Ladderanes; 5 Other Linear Templates; 5.1 1,8-Naphthalenedicarboxylic Acid; 5.2 Bis-p-phenylene[34]-crown[10] 327 $a5.3 Carballylic and 1,2,4,5-Benzenetetracarboxylic Acids5.4 Tetrakis(4-iodoperfluorophenyl)erythritol; 6 Summary and Outlook; References; 4 Interplay of Non-covalent Bonds: Effect of Crystal Structure on Molecular Structure; 1 Introduction; 2 Second-Sphere Coordination; 3 Soft Coordination Environments; 3.1 Mercury and Tin; 3.2 Comparison with Calculation; 3.3 Influence of Disorder; 4 Speciation; 5 Molecular Conformation; 6 Conclusions; References; 5 Crystal Engineering of Halogenated Heteroaromatic Clathrate Systems; 1 Introduction; 1.1 Clathrates; 1.2 New Clathrand Inclusion Hosts 327 $a1.3 Halogenated Heteroaromatic Hosts2 Aromatic Edge-Edge C-H· · ·N Dimers; 3 Heteroatom-1,3-Peri Interactions; 3.1 The Ether-1,3-Peri Aromatic Hydrogen Interaction; 3.2 The Thioether-and Aza-1,3-Peri Aromatic Hydrogen Interactions; 4 Molecular Pen Structures; 5 Halogenated Edge-Edge Interactions; 6 Pi-Halogen Dimer (PHD) Interactions; 6.1 A New Aromatic Building Block; 6.2 Staircase Inclusion Compounds; 6.3 Layer Inclusion Compounds; 7 Molecular Bricks, Spheres and Grids; 7.1 Bricks and Mortar Inclusion Systems; 7.2 Molecular Spheres of Variable Composition; 7.3 Interlocking Molecular Grids 327 $a8 Conclusions 330 $aCrystal engineering - where the myriad of intermolecular forces operating in the solid-state are employed to design new nano- and functional materials - is a key new technology with implications for catalysis, pharmaceuticals, synthesis and materials science.Frontiers in Crystal Engineering gathers personal perspectives, from international specialists working in molecular aspects of crystal engineering, on the practical and theoretical challenges of the discipline, and future prospects. These demonstrate the approaches that are being used to tackle the problems associated with the comp 606 $aMolecular crystals$xResearch 608 $aElectronic books. 615 0$aMolecular crystals$xResearch. 676 $a548 676 $a548.81 701 $aTiekink$b Edward R. T$0867117 701 $aVittal$b Jagadese J$0958289 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143744803321 996 $aFrontiers in crystal engineering$92171187 997 $aUNINA