LEADER 04171nam 2200673Ia 450 001 9910143723303321 005 20170815120524.0 010 $a1-280-35575-1 010 $a9786610355754 010 $a0-470-02923-4 010 $a0-470-02922-6 035 $a(CKB)1000000000357343 035 $a(EBL)255332 035 $a(OCoLC)163585395 035 $a(SSID)ssj0000264555 035 $a(PQKBManifestationID)11192258 035 $a(PQKBTitleCode)TC0000264555 035 $a(PQKBWorkID)10291333 035 $a(PQKB)11651827 035 $a(MiAaPQ)EBC255332 035 $a(EXLCZ)991000000000357343 100 $a20060601d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aUnderstanding nicotine and tobacco addiction$b[electronic resource] /$f[editors, Gregory Bock and Jamie Goode} 210 $aChichester, UK ;$aHoboken, NJ $cJohn Wiley & Sons$dc2006 215 $a1 online resource (285 p.) 225 1 $aNovartis Foundation symposium ;$v275 300 $aSymposium held at the Novartis Foundation, London, 17-19 May 2005. 311 $a0-470-01657-4 320 $aIncludes bibliographical references and indexes. 327 $aCover; Contents; Chair's introduction; The hazards of smoking and the benefits of stopping; DISCUSSION; Animal models for nicotine dependence; DISCUSSION; Defining and assessing nicotine dependence in humans; DISCUSSION; General discussion I; Nicotinic acetylcholine receptor functions in the CNS investigated with a novel method of stereotaxic gene re-expression in knockout mice; DISCUSSION; Nicotine-mediated activation of signal transduction pathways; DISCUSSION; Complementary roles for the accumbal shell and core in nicotine dependence; DISCUSSION 327 $aThe dopamine D3 system: new opportunities for dopamine-based rewardDISCUSSION; Pathways and systems involved in nicotine dependence; DISCUSSION; Localizing tobacco dependence pathways with functional brain imaging; DISCUSSION; Pharmacogenetic approaches to nicotine dependence treatment; DISCUSSION; Pharmacogenomics and smoking cessation; DISCUSSION; General discussion II; Power in studies; Receptor desensitization; What limits the efficacy of current nicotine replacement therapies?; DISCUSSION; Exploring behavioural mechanisms of nicotine replacement therapy for smoking cessation; DISCUSSION 327 $aModifying the metabolism of nicotine as a therapeutic strategyDISCUSSION; Challenges in discovery and development of pharmacotherapies for tobacco addiction; DISCUSSION; Final discussion; Nicotine comorbidity; Animal models; Contributor Index; Subject Index 330 $aCigarette smoking is estimated to lead to 4.9 million premature deaths per year worldwide. This is predicted to rise to 10 million by 2020. In western countries it kills half of all smokers who fail to stop.The prevailing model for tobacco addiction is that nicotine from cigarettes rewards smoking and punishes abstinence, tapping into a motivational system of operant conditioning that requires no conscious awareness. However, there are also accounts which involve cognitive biases and the effect of nicotine on impulse control. The brain pathways involved have been studied extensively, b 410 0$aNovartis Foundation symposium ;$v275. 606 $aNicotine addiction$vCongresses 606 $aTobacco use$xPhysiological aspects$vCongresses 606 $aTobacco use$xPsychological aspects$vCongresses 606 $aSmoking cessation$vCongresses 608 $aElectronic books. 615 0$aNicotine addiction 615 0$aTobacco use$xPhysiological aspects 615 0$aTobacco use$xPsychological aspects 615 0$aSmoking cessation 676 $a616.865 701 $aBock$b Gregory$0322650 701 $aGoode$b Jamie$0283336 712 12$aSymposium on Understanding Nicotine and Tobacco Addiction$f(2005 :$eLondon, England) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143723303321 996 $aUnderstanding nicotine and tobacco addiction$92246794 997 $aUNINA