LEADER 04807nam 22006014a 450 001 9910143712203321 005 20170815115539.0 010 $a1-280-41112-0 010 $a9786610411122 010 $a0-470-03409-2 010 $a0-470-03324-X 035 $a(CKB)1000000000357377 035 $a(EBL)255725 035 $a(OCoLC)161994171 035 $a(SSID)ssj0000176910 035 $a(PQKBManifestationID)11165722 035 $a(PQKBTitleCode)TC0000176910 035 $a(PQKBWorkID)10210102 035 $a(PQKB)10443710 035 $a(MiAaPQ)EBC255725 035 $a(PPN)137628463 035 $a(EXLCZ)991000000000357377 100 $a20050923d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aImmunogenomics and human disease$b[electronic resource] /$f[edited by] Andra?s Falus 210 $aChichester, West Sussex, England ;$aHoboken, NJ $cJohn Wiley$dc2006 215 $a1 online resource (558 p.) 300 $aDescription based upon print version of record. 311 $a0-470-01530-6 320 $aIncludes bibliographical references and index. 327 $aImmunogenomics and Human Disease; Contents; Preface; List of Contributors; 1 Genotyping methods and disease gene identification; 1.1 Introduction; 1.2 Genotyping of single-nucleotide polymorphisms; 1.3 Methods for interrogating SNPs; 1.4 Analysis formats; 1.5 The current generation of methods for SNP genotyping; 1.6 The next generation; 1.7 Classical HLA typing; 1.8 MHC haplotypes; 1.9 Molecular haplotyping; 1.10 Microhaplotyping; 1.11 MHC and disease associations; 1.12 Conclusions; Acknowledgements; References 327 $a2 Glycomics and the sugar code: primer to their structural basis and functionality2.1 Introduction; 2.2 Lectins as effectors in functional glycomics; 2.3 Galectins: structural principles and intrafamily diversity; 2.4 Ligand-dependent levels of affinity regulation; 2.5 Perspectives for galectin-dependent medical applications; 2.6 Conclusions; References; 3 Proteomics in clinical research: perspectives and expectations; 3.1 Introduction; 3.2 Proteomics: tools and projects; 3.3 Discussion; 3.4 Concluding remarks; Acknowledgements; References 327 $a4 Chemical genomics: bridging the gap between novel targets and small molecule drug candidates. Contribution to immunology4.1 Introduction of chemical genomics: definitions; 4.2 Chemical microarrays; 4.3 Small molecule and peptide probes for studying binding interactions through creating a covalent bond; 4.4 Photochemical proteomics; 4.5 General aspects of photoaffinity labelling; 4.6 Photoreactive probes of biomolecules; 4.7 Application to the immunobiology of living cells; 4.8 Multifunctional photoprobes for rapid analysis and screening; 4.9 Advanced application to functional proteomics 327 $a4.10 SummaryReferences; 5 Genomic and proteomic analysis of activated human monocytes; 5.1 Primary human monocytes, as a model system; 5.2 Transcriptional profiling of activated monocytes; 5.3 Functional genomics; 5.4 Proteomic analysis of activated human monocytes; References; 6 Bioinformatics as a problem of knowledge representation: applications to some aspects of immunoregulation; 6.1 Introduction; 6.2 Sequences and languages; 6.3 Three-dimensional models; 6.4 Genomes, proteomes, networks; 6.5 Computational tools; 6.6 Information processing in the immune system; 6.7 Concluding remarks 327 $aReferences7 Immune responsiveness of human tumours; 7.1 Introduction; 7.2 Defining tumour immune responsiveness; 7.3 Studying immune responsiveness in human tumours; 7.4 Immune responsiveness in the context of therapy; 7.5 The spatial dimension in the quest for the target; 7.6 Studying the receiving end - tumour as an elusive target for immune recognition; 7.7 The role of the host in determining immune responsiveness; 7.8 Concluding remarks; References; 8 Chemokines regulate leukocyte trafficking and organ-specific metastasis; 8.1 Chemokines and chemokine receptors 327 $a8.2 Chemokine receptors in the organ-specific recruitment of tumour cells 330 $aThis book provides an overview of key conceptual and molecular technologies being deployed in immunogenomics, followed by detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection. 606 $aImmunogenetics 615 0$aImmunogenetics. 676 $a616.0796 676 $a616.979 701 $aFalus$b Andra?s$0923310 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143712203321 996 $aImmunogenomics and human disease$92072063 997 $aUNINA