LEADER 05494nam 2200697Ia 450 001 9910143703003321 005 20180718142419.0 010 $a1-280-51878-2 010 $a9786610518784 010 $a0-470-02811-4 010 $a0-470-02810-6 035 $a(CKB)1000000000357390 035 $a(EBL)267154 035 $a(OCoLC)304138674 035 $a(SSID)ssj0000209686 035 $a(PQKBManifestationID)11184146 035 $a(PQKBTitleCode)TC0000209686 035 $a(PQKBWorkID)10267400 035 $a(PQKB)10414385 035 $a(MiAaPQ)EBC267154 035 $a(EXLCZ)991000000000357390 100 $a20051107d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aNeurodegenerative diseases and metal ions$b[electronic resource] /$fedited by Astrid Sigel, Helmut Sigel, and Roland K.O. Sigel 210 $aChichester, West Sussex, England ;$aHoboken, NJ $cWiley$dc2006 215 $a1 online resource (489 p.) 225 1 $aMetal ions in life sciences ;$vv. 1 300 $aDescription based upon print version of record. 311 $a0-470-01488-1 320 $aIncludes bibliographical references and index. 327 $aMetal Ions in Life Sciences; Historical Development and Perspectives of the Series; Preface to Volume 1; Contents; Contributors to Volume 1; Titles of Volumes 1-44 in the Metal Ions in Biological Systems Series; Contents of Volumes in the Metal Ions in Life Sciences Series; 1 The Role of Metal Ions in Neurology. An Introduction; 1 Introductory Remarks; 2 Comments on Metal Ions in Neurology; Acknowledgments; Abbreviations; References; 2 Protein Folding, Misfolding, and Disease; 1 Introduction; 2 Experimental Methods; 3 The Denatured State; 4 Protein Folding Dynamics 327 $a5 ?-Synuclein and Parkinson's Disease6 Conclusions and Outlook; Acknowledgments; Abbreviations and Definitions; References; 3 Metal Ion Binding Properties of Proteins Related to Neurodegeneration; 1 Introduction; 2 Cu2+ Interactions with Mammalian Prion Proteins and Their Fragments; 3 Interactions of Metal Ions with the Amyloid Precursor Protein and Its Fragments; 4 Concluding Remarks; Acknowledgments; Abbreviations; References; 4 Metallic Prions: Mining the Core of Transmissible Spongiform Encephalopathies; 1 Introduction 327 $a2 Historical Connections Between Copper and Transmissible Spongiform Encephalopathies3 Copper Binding to Prion Protein; 4 Copper Coordination by Prion Protein; 5 Copper Uptake and Prion Protein Internalization; 6 Prion Protein as an Antioxidant; 7 Manganese Binding; 8 Transmissible Spongiform Encephalopathies and Metals; 9 Conclusions; Abbreviations; References; 5 The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease; 1 Introduction; 2 Amyloid Precursor Protein and Brain Copper Homeostasis; 3 Amyloid Precursor Protein and Cu,Zn-Superoxide Dismutase-1 327 $a4 General ConclusionsAbbreviations; References; 6 The Role of Iron in the Pathogenesis of Parkinson's Disease; 1 Introduction; 2 Iron in the Etiology of Parkinson's Disease; 3 Sources of Increased Iron in Parkinson's Disease; 4 Consequences of Iron Overload in Parkinson's Disease; 5 General Conclusions; Acknowledgments; Abbreviations and Definitions; References; 7 In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases; 1 Introduction. Puzzling Changes in Cell Numbers in Huntington's Disease Brain 327 $a2 Human Brain Development and Disease Phenotypes3 Oligodendrocytes and Iron in Brain Development and Degeneration; 4 Transition Metal Metabolism and Proteinopathies; 5 In Vivo Measurement of Brain Iron; 6 Novel Treatment Considerations; 7 Conclusions; Acknowledgments; Abbreviations; References; 8 Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis; 1 Introduction; 2 Molecular Mechanisms of fALS SOD1 Pathogenesis; 3 Structural Features of Human SOD1; 4 'Wild-Type-like' fALS Mutants; 5 'Metal Binding Region' fALS Mutants; 6 Monomeric SOD1 and Pathogenesis; 7 Conclusions 327 $aAcknowledgments 330 $aAbout the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, t 410 0$aMetal ions in life sciences ;$vv. 1. 606 $aNervous system$xDegeneration 606 $aNervous system$xDiseases 606 $aMetal ions$xHealth aspects 608 $aElectronic books. 615 0$aNervous system$xDegeneration. 615 0$aNervous system$xDiseases. 615 0$aMetal ions$xHealth aspects. 676 $a572.51 676 $a616.8 701 $aSigel$b Astrid$091114 701 $aSigel$b Helmut$091115 701 $aSigel$b Roland K. O$0928871 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143703003321 996 $aNeurodegenerative diseases and metal ions$92146241 997 $aUNINA