LEADER 04051nam 2200661Ia 450 001 9910143702703321 005 20170815123502.0 010 $a1-280-30875-3 010 $a9786610308750 010 $a0-470-03344-4 010 $a0-470-03051-8 035 $a(CKB)1000000000357411 035 $a(EBL)244901 035 $a(OCoLC)71634293 035 $a(SSID)ssj0000198616 035 $a(PQKBManifestationID)11954281 035 $a(PQKBTitleCode)TC0000198616 035 $a(PQKBWorkID)10183914 035 $a(PQKB)10327927 035 $a(MiAaPQ)EBC244901 035 $a(EXLCZ)991000000000357411 100 $a20041011d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMast cells and basophils$b[electronic resource] $edevelopment, activation and roles in allergic/autoimmune disease 210 $aChichester $cJohn Wiley$d2005 215 $a1 online resource (275 p.) 225 1 $aNovartis Foundation symposium ;$v271 300 $aSymposium on mast cells and basophils : development, activation and roles in allergic/autoimmune disease, held at the Novartis Foundation, London, 16-18 November 2004. 311 $a0-470-01312-5 320 $aIncludes bibliographical references and indexes. 327 $aMAST CELLS AND BASOPHILS: DEVELOPMENT, ACTIVATION AND ROLES IN ALLERGIC/AUTOIMMUNE DISEASE; Contents; Participants; Chair's introduction; MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells; Discussion; Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells; Discussion; The role of Src family kinases in mast cell effector function; Discussion; RasGRP4 in mast-cell signalling and disease susceptibility; Discussion 327 $aRegulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitisationDiscussion; General discussion I; IgE regulation of mast cell survival and function; Discussion; RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation; Discussion; Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology; Discussion; The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract 327 $aDiscussionThe mast cell and the cysteinyl leukotrienes; Discussion; Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes; Discussion; The involvement of Bcl-2 in mast cell apoptosis; Discussion; General discussion II; General discussion III; Mast cells in autoantibody responses and arthritis; Discussion; MASTering the immune response: mast cells in autoimmunity; Discussion; Mastocytosis; Discussion; Index of contributors; Subject index 330 $aThe book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes. 410 0$aNovartis Foundation symposium ;$v271. 606 $aMast cells 606 $aBasophils 608 $aElectronic books. 610 1 $aAutoimmune disease 610 1 $aAllergic disease 610 2 $aNovartis 615 0$aMast cells. 615 0$aBasophils. 676 $a616.079 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143702703321 996 $aMast cells and basophils$92873313 997 $aUNINA