LEADER 04232nam 22006134a 450 001 9910143579703321 005 20170815113749.0 010 $a1-280-27658-4 010 $a9786610276585 010 $a0-470-24248-5 010 $a0-471-72103-4 010 $a0-471-72102-6 035 $a(CKB)1000000000355700 035 $a(EBL)238764 035 $a(OCoLC)475949390 035 $a(SSID)ssj0000180323 035 $a(PQKBManifestationID)11165564 035 $a(PQKBTitleCode)TC0000180323 035 $a(PQKBWorkID)10148643 035 $a(PQKB)10909546 035 $a(MiAaPQ)EBC238764 035 $a(PPN)137628706 035 $a(EXLCZ)991000000000355700 100 $a20050204d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIntegrated strategies for drug discovery using mass spectrometry$b[electronic resource] /$f[edited by] Mike S. Lee 210 $aHoboken, N.J. $cWiley-Interscience$dc2005 215 $a1 online resource (570 p.) 225 1 $aWiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods 300 $aDescription based upon print version of record. 311 $a0-471-46127-X 327 $aMiniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic -- Mass spectrometry based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery -- Mass spectrometry based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert -- Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng -- A Combinatorial process for drug discovery / David S. Wagner -- Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang -- Advances in high-throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC/MS strategy for preclinical candidate optimization / Jonathan L. Josephs -- New approaches for method development and purification in lead optimization / Yining Zhao -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns -- Organ perfusion and mass spectrometry / C. Gerald Curtis -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock. 330 $aNew strategies and techniques for today's fast-paced discovery processToday, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery.Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review o 410 0$aWiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods 606 $aMass spectrometry 606 $aDrugs$xAnalysis 606 $aHigh throughput screening (Drug development) 615 0$aMass spectrometry. 615 0$aDrugs$xAnalysis. 615 0$aHigh throughput screening (Drug development) 676 $a615.19 676 $a615/.19 701 $aLee$b Mike S.$f1960-$0895753 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143579703321 996 $aIntegrated strategies for drug discovery using mass spectrometry$92001040 997 $aUNINA