LEADER 04094nam 22006134a 450 001 9910143557703321 005 20170809162037.0 010 $a1-280-54982-3 010 $a9786610549825 010 $a0-470-04340-7 010 $a0-470-04339-3 035 $a(CKB)1000000000355351 035 $a(EBL)270458 035 $a(OCoLC)476004231 035 $a(SSID)ssj0000159870 035 $a(PQKBManifestationID)11163367 035 $a(PQKBTitleCode)TC0000159870 035 $a(PQKBWorkID)10158686 035 $a(PQKB)11401578 035 $a(MiAaPQ)EBC270458 035 $a(EXLCZ)991000000000355351 100 $a20060516d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFundamentals of early clinical drug development$b[electronic resource] $efrom synthesis design to formulation /$fedited by Ahmed F. Abdel-Magid and Ste?phane Caron 210 $aHoboken, N.J. $cWiley-Interscience$dc2006 215 $a1 online resource (341 p.) 300 $aDescription based upon print version of record. 311 $a0-471-69278-6 320 $aIncludes bibliographical references and index. 327 $aReflections on process research II / Edward J.J. Grabowski -- Development and scale-up of a heterocyclic cross-coupling for the synthesis of 5-(2-(3-methyl-3H-imidazol-4-yl)thieno(3,2-b)pyridin-7-yl)amino-2-methyl-1H-indol / John A. Ragan -- Large-scale enantioselective preparation of 2E,7E, 5S,6R, 5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoic acid, a key fragment for the formal total synthesis of the anti-tumor agent cryptophycin 52 / James Aikins ... [et al.] -- Efforts toward a commercially viable route and process to the synthesis of HIV PI GW640385X / John C. Roberts ... [et al.] -- Development of an asymmetric synthesis of ABT-100 / Albert W. Kruger ... [et al.] -- Asymmetric hydrogenation: a new route to pregabalin / Rex Jennings ... [et al.] -- Responsibilities of the process chemist: beyond synthetic organic chemistry / Ste?phane Caron -- Outsourcing: the challenge of science, speed, and quality / Simone Andler-Burzlaff, Jason Bertola, and Roger E. Marti -- Automation and the changing face of process research in the pharmaceutical industry / Edward J. Delaney ... [et al.] -- Large scale synthesis: an engineering perspective / Joseph H. Childers, Jr. -- Synthesis and application of radioisotopes in pharmaceutical research and development / Larry E. Weaner and David C. Hoerr -- Selection of the drug form in exploratory development / George J. Quallich -- Strategies to control particle size of active pharmaceutical ingredients / David J. am Ende and Peter R. Rose -- Challenges in early formulation: turning drug substance into drug product / Mark H. Kleinman and Beeah Lee -- Intellectual property and early development / Maria I. Shchuka. 330 $aAn informative look at the intricacies of today's drug development processOnce a discovery organization has identified a potential new drug candidate, it is the daunting task of synthetic organic chemists to identify the chemical process suitable for preparation of this compound in a highly regulated environment. Only through a multi-layered chemical process that takes into account such factors as safety, environmental considerations, freedom to operate and cost-effectiveness can researchers begin to refine the drug in terms of quality and yield.This book covers both re 606 $aClinical pharmacology 606 $aPharmaceutical technology 606 $aDrugs$xTesting 608 $aElectronic books. 615 0$aClinical pharmacology. 615 0$aPharmaceutical technology. 615 0$aDrugs$xTesting. 676 $a615.1 676 $a615.19 676 $a615/.1 701 $aAbdel-Magid$b Ahmed F.$f1947-$0981319 701 $aCaron$b Ste?phane$0865531 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143557703321 996 $aFundamentals of early clinical drug development$92239857 997 $aUNINA LEADER 04284nam 2200733 450 001 996308765803316 005 20230523104637.0 010 $a3-11-041788-X 010 $a3-11-044036-9 024 7 $a10.1515/9783110440362 035 $a(CKB)3710000000496995 035 $a(SSID)ssj0001583127 035 $a(PQKBManifestationID)16257566 035 $a(PQKBTitleCode)TC0001583127 035 $a(PQKBWorkID)13782932 035 $a(PQKB)11474770 035 $a(MiAaPQ)EBC4006855 035 $a(WaSeSS)IndRDA00057297 035 $a(DE-B1597)444710 035 $a(OCoLC)940512176 035 $a(OCoLC)979589815 035 $a(OCoLC)980283946 035 $a(DE-B1597)9783110440362 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56232 035 $a(EXLCZ)993710000000496995 100 $a20160121h20152015 uy 0 101 0 $ager 135 $aurcn#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPhysik und poetik $eproduktionsa?sthetik und werkgenese : autorinnen und autoren im dialog /$fherausgegeben von Aura Heydenreich und Klaus Mecke 210 $cDe Gruyter$d2015 210 1$aBerlin, [Germany] ;$aBoston, [Massachusetts] :$cDe Gruyter,$d2015. 210 4$d©2015 215 $a1 online resource (320 pages) $cdigital, PDF file(s) 225 1 $aLiteratur- und Naturwissenschaften ;$vBand 1 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$aPrint version: 9783110406511 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $tFrontmatter -- Inhalt -- Dialogisches Denken -- Auf der Suche nach Sprache / Heydenreich, Aura / Mecke, Klaus -- Librationen / Heydenreich, Aura / Mecke, Klaus -- Fiktionen, Simulationen, Dialoge. Erkenntnisstrategien in Wissenschaft, Erzählung und Philosophie / Heydenreich, Aura / Mecke, Klaus -- Evolution im Comic / Heydenreich, Aura / Heydenreich, Clemens -- Horizonte der Einsamkeit / Heydenreich, Aura / Mecke, Klaus -- Die Zeit ist der Abgrund, in den wir fallen / Heydenreich, Aura / Mecke, Klaus -- Sokratische Dialoge / Heydenreich, Aura / Mecke, Klaus -- Romane schreiben wäre eine Lösung. Über die Vernetzung von Naturwissenschaft und Literatur / Heydenreich, Aura / Mecke, Klaus -- Physik und Ethik / Heydenreich, Aura / Mecke, Klaus -- Anhang -- Interviewer -- Index 330 $aMany writers deal intensively with the knowledge of physics that shapes the worldview, often ignored by literary criticism and science. Their reasons are as varied as the books they write. Letting them have their say in interviews enriches the discourse about the two cultures with a voice that knows both: literature and physics. We encounter physics in all areas of life; Starting with devices in the engineered civilization, over the description of phenomena in nature up to the fundamental understanding of the world, which has become different through quantum and relativity theory. It is therefore not surprising that writers use physical knowledge to tell about people and the world in which they live. Experimental literature and metaphors in physical theories are just two subjects that come up in the interviews with Ulrike Draesner, Durs Grünbein, Michael Hampe, Jens Harder, Reinhard Jirgl, Thomas Lehr, Ulrich Woelk and Juli Zeh. Everyone agrees that physics and literature are two ways of knowing the world that complement and condition each other. 410 0$aLiteratur- und Naturwissenschaften ;$vBand 1. 606 $aGerman literature$y20th century$xHistory and criticism 606 $aAuthors, German$y20th century$vInterviews 606 $aPhysics in literature 610 $aLiterature 610 $aPhysics 610 $aInterview 615 0$aGerman literature$xHistory and criticism. 615 0$aAuthors, German 615 0$aPhysics in literature. 676 $a830.9/36 700 $aMecke$b Klaus$4auth$028564 702 $aHeydenreich$b Aura Maria 702 $aMecke$b Klaus R.$f1964- 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 801 2$bUkMaJRU 906 $aBOOK 912 $a996308765803316 996 $aPhysik und poetik$93363971 997 $aUNISA