LEADER 04820nam 2200661 450 001 9910466108203321 005 20200520144314.0 010 $a3-527-80015-8 035 $a(CKB)3710000000616927 035 $a(EBL)4451530 035 $a(SSID)ssj0001683000 035 $a(PQKBManifestationID)16508429 035 $a(PQKBTitleCode)TC0001683000 035 $a(PQKBWorkID)15037253 035 $a(PQKB)10095136 035 $a(MiAaPQ)EBC4451530 035 $a(PPN)199263493 035 $a(Au-PeEL)EBL4451530 035 $a(CaPaEBR)ebr11174089 035 $a(OCoLC)945137775 035 $a(EXLCZ)993710000000616927 100 $a20160324h20162016 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aReceptor biology /$fMichael F. Roberts and Anne E. Kruhchten 210 1$aWeinheim, Germany :$cWiley-VCH Verlag GmBH & Company KGaA,$d[2016] 210 4$dİ2016 215 $a1 online resource (478 p.) 300 $aDescription based upon print version of record. 311 $a3-527-33726-1 320 $aIncludes bibliographical references and index. 327 $aTitle Page; Copyright; Dedication; Table of Contents; Acknowledgments; Part I: Introduction; Chapter 1: Introduction; 1.1 Receptors and Signaling; 1.2 Types of Receptors and Hormones; 1.3 Receptors Are the Chemical Expression of Reality; Chapter 2: The Origins of Chemical Thinking; 2.1 Overview of Early Pharmacological History; 2.2 Modern Pharmacology; 2.3 Phylogenetics of Signaling; Part II: Fundamentals; Chapter 3: Membranes and Proteins; 3.1 Membranes; 3.2 The Nature and Function of Proteins; Chapter 4: Hormones as First Messengers; 4.1 Hormones and Cellular Communication 327 $a4.2 Types of Hormones4.3 Vertebrate Hormones and Transmitters; 4.4 Analgesics and Venoms as Receptor Ligands; Chapter 5: Receptor Theory; 5.1 The Materialization of Receptors; 5.2 Receptor Mechanisms; 5.3 Binding Theory; 5.4 Visualizing Receptor Structure and Function; 5.5 Proteomics Approaches to Receptor Efficacy; 5.6 Physical Factors Affecting Receptor Binding; Part III: Receptor Types and Function; Chapter 6: Transduction I: Ion Channels and Transporters; 6.1 Introduction; 6.2 Small Molecule Channels; 6.3 Transporters; 6.4 Major Intrinsic Proteins; 6.5 Ligand-Gated Ion Channels 327 $aChapter 7: Transduction II: G-Protein-Coupled Receptors7.1 Introduction; 7.2 Families of G-Protein-Coupled Receptors; 7.3 Transduction Mechanisms; 7.4 The Major Families of G Protein-Coupled Receptors; Chapter 8: Transduction III: Receptor Kinases and Immunoglobulins; 8.1 Protein Kinases; 8.2 Receptors for Cell Division and Metabolism; 8.3 Receptor Serine/Threonine Kinases; 8.4 The Guanylyl Cyclase Receptor Subfamily - Natriuretic Peptide Receptors; 8.5 Non-Kinase Molecules - LDL Receptors; 8.6 Cell-Cell Contact Signaling; 8.7 Immune System Receptors, Antibodies, and Cytokines 327 $aChapter 9: Transduction IV: Nuclear Receptors9.1 Introduction; 9.2 Genomic Actions of Nuclear Receptors; 9.3 Actions of Receptor Antagonists; 9.4 Non-Traditional Actions of Steroid-Like Hormones and Their Receptors; Part IV: Applications; Chapter 10: Signaling Complexity; 10.1 Introduction; 10.2 Experimental Determination of Signaling Cascades; 10.3 Transduction across the Membrane; 10.4 Complexity in Cross Talk - Roles of PIP3, Akt, and PDK1; 10.5 Role in Cancer; 10.6 Signaling Mediated by Gas Molecules; Chapter 11: Cellular Interactions in Development; 11.1 Introduction 327 $a11.2 The Origins of Multicellularity11.3 The Origin of Symmetry and Axes; 11.4 Fertilization and Organization of the Multicellular Body Plan; 11.5 Differentiation of Triploblastic Embryos - Organogenesis; 11.6 Programmed Cell Death (Apoptosis); Chapter 12: Receptor Mechanisms in Disease Processes; 12.1 Genetic Basis for Receptor Function; 12.2 Receptor Pathologies; 12.3 Signaling Mutations Leading to Cancer; Chapter 13: Receptors and the Mind; 13.1 Origins of Behavior; 13.2 Nervous Systems; 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