LEADER 05520nam 2200733Ia 450 001 9910143402603321 005 20200520144314.0 010 $a1-118-67846-X 010 $a1-280-91677-X 010 $a9786610916771 010 $a0-470-13497-6 010 $a0-470-13496-8 035 $a(CKB)1000000000354880 035 $a(EBL)304940 035 $a(OCoLC)476082283 035 $a(SSID)ssj0000105855 035 $a(PQKBManifestationID)11128021 035 $a(PQKBTitleCode)TC0000105855 035 $a(PQKBWorkID)10102189 035 $a(PQKB)11068877 035 $a(MiAaPQ)EBC304940 035 $a(MiAaPQ)EBC4037460 035 $a(Au-PeEL)EBL304940 035 $a(CaPaEBR)ebr10278788 035 $a(Au-PeEL)EBL4037460 035 $a(CaPaEBR)ebr11111745 035 $a(CaONFJC)MIL91677 035 $a(OCoLC)958544737 035 $a(EXLCZ)991000000000354880 100 $a20070427d2007 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe art of drug synthesis /$fedited by Douglas S. Johnson, Jie Jack Li 205 $a1st ed. 210 $aHoboken, N.J. $cWiley-Interscience$dc2007 215 $a1 online resource (xv, 276 pages) $cillustrations 225 1 $aWiley Series on Drug Synthesis 311 0 $a0-471-75215-0 320 $aIncludes bibliographical references and index. 327 $aTHE ART OF DRUG SYNTHESIS; CONTENTS; Foreword; Preface; Contributors; 1 THE ROLE OF MEDICINAL CHEMISTRY IN DRUG DISCOVERY; 1.1 Introduction; 1.2 Hurdles in the Drug Discovery Process; 1.3 The Tools of Medicinal Chemistry; 1.3.1 In Silico Modeling; 1.3.2 Structure-Based Drug Design (SBDD); 1.4 The Role of Synthetic Chemistry in Drug Discovery; References; 2 PROCESS RESEARCH: HOW MUCH? HOW SOON?; 2.1 Introduction; 2.2 Considerations for Successful Scale-up to Tox Batches and Phase I Material; 2.3 Considerations for Phase 2 Material and Beyond; 2.3.1 Reagent Selection; 2.3.2 Solvent Selection 327 $a2.3.3 Unit Operations; 2.3.4 Developing Simple, Effective, Efficient Work-ups and Isolations; 2.3.5 The Importance of Physical States; 2.3.6 Route Design and Process Optimization to Minimize COG; 2.4 Summary; References; I CANCER AND INFECTIOUS DISEASES; 3 AROMATASE INHIBITORS FOR BREAST CANCER: EXEMESTANE (AROMASIN®), ANASTROZOLE (ARIMIDEX®), AND LETROZOLE (FEMARA®); 3.1 Introduction; 3.2 Synthesis of Exemestane; 3.3 Synthesis of Anastrozole; 3.4 Synthesis of Letrozole; References 327 $a4 QUINOLONE ANTIBIOTICS: LEVOFLOXACIN (LEVAQUIN®), MOXIFLOXACIN (AVELOX®), GEMIFLOXACIN (FACTIVE®), AND GARENOXACIN (T-3811)4.1 Introduction; 4.1.1 Mechanism of Action; 4.1.2 Modes of Resistance; 4.1.3 Structure-Activity Relationship (SAR) and Structure-Toxicity Relationship (STR); 4.1.4 Pharmacokinetics; 4.1.5 Synthetic Approaches; 4.2 Levofloxacin; 4.3 Moxifloxacin; 4.4 Gemifloxacin; 4.5 Garenoxacin (T-3811): A Promising Clinical Candidate; References; 5 TRIAZOLE ANTIFUNGALS: ITRACONAZOLE (SPORANOX®), FLUCONAZOLE (DIFLUCAN®), VORICONAZOLE (VFEND®), AND FOSFLUCONAZOLE (PRODIF®) 327 $a5.1 Introduction; 5.2 Synthesis of Itraconazole; 5.3 Synthesis of Fluconazole; 5.4 Synthesis of Voriconazole; 5.5 Synthesis of Fosfluconazole; References; 6 NON-NUCLEOSIDE HIV REVERSE TRANSCRIPTASE INHIBITORS; 6.1 Introduction; 6.2 Synthesis of Nevirapine; 6.3 Synthesis of Efavirenz; 6.4 Synthesis of Delavirdine Mesylate; References; 7 NEURAMINIDASE INHIBITORS FOR INFLUENZA: OSELTAMIVIR PHOSPHATE (TAMIFLU®) AND ZANAMIVIR (RELENZA®); 7.1 Introduction; 7.1.1 Relenza; 7.1.2 Tamiflu; 7.2 Synthesis of Oseltamivir Phosphate (Tamiflu®); 7.3 Synthesis of Zanamivir (Relenza®); References 327 $aII CARDIOVASCULAR AND METABOLIC DISEASES; 8 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) AGONISTS FOR TYPE 2 DIABETES; 8.1 Introduction; 8.1.1 Insulin; 8.1.2 Sulfonylurea Drugs; 8.1.3 Meglitinides; 8.1.4 Biguanides; 8.1.5 Alpha-Glucosidase Inhibitors; 8.1.6 Thiazolidinediones; 8.2 Synthesis of Rosiglitazone; 8.3 Synthesis of Pioglitazone; 8.4 Synthesis of Muraglitazar; References; 9 ANGIOTENSIN AT(1) ANTAGONISTS FOR HYPERTENSION; 9.1 Introduction; 9.2 Losartan Potassium; 9.2.1 Introduction to Losartan Potassium; 9.2.2 Synthesis of Losartan Potassium; 9.3 Valsartan; 9.3.1 Introduction to Valsartan 330 $aThe Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.Edited by prominent scientists working in drug discovery for PfizerM 410 0$aWiley Series on Drug Synthesis 606 $aDrugs$xDesign 606 $aPharmaceutical chemistry 615 0$aDrugs$xDesign. 615 0$aPharmaceutical chemistry. 676 $a615.19 676 $a615/.19 701 $aJohnson$b Douglas S$g(Douglas Scott),$f1968-$0866629 701 $aLi$b Jie Jack$0440094 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143402603321 996 $aThe art of drug synthesis$91934515 997 $aUNINA