LEADER 04481nam 2200673Ia 450 001 9910143168203321 005 20170815111947.0 010 $a1-280-26991-X 010 $a9786610269914 010 $a0-470-66848-2 010 $a0-470-85293-3 010 $a0-470-85305-0 035 $a(CKB)111087027094324 035 $a(EBL)152676 035 $a(OCoLC)52546963 035 $a(SSID)ssj0000239225 035 $a(PQKBManifestationID)11199913 035 $a(PQKBTitleCode)TC0000239225 035 $a(PQKBWorkID)10239312 035 $a(PQKB)10816863 035 $a(MiAaPQ)EBC152676 035 $a(EXLCZ)99111087027094324 100 $a20020628d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRole of the sarcoplasmic reticulum in smooth muscle$b[electronic resource] /$f[editors, Derek J. Chadwick and Jamie A. Goode] 210 $aChichester ;$aNew York $cJ. Wiley$d2002 215 $a1 online resource (297 p.) 225 1 $aNovartis Foundation symposium ;$v246 300 $aProceedings of the Symposium on Role of the Sarcoplasmic Reticulum in Smooth Muscle held at the Novartis Foundation, London, Oct. 30-Nov. 1, 2001. 311 $a0-470-84479-5 320 $aIncludes bibliographical references and indexes. 327 $aROLE OF THE SARCOPLASMIC RETICULUM IN SMOOTH MUSCLE; Contents; Participants; Chair's introduction; Role of the sarcoplasmic reticulum in uterine smooth muscle; Discussion; Relationship between the sarcoplasmic reticulum and the plasma membrane; Discussion; General discussion I The role of calmodulin in smooth muscle contraction; Ca(2+) signalling and Ca(2+)-activated K(+) channels in smooth muscle; Discussion; Additional fluxes of activator Ca(2+) accompanying Ca(2+) release from the sarcoplasmic reticulum triggered by InsP(3)-mobilizing agonists; Discussion 327 $aMolecular candidates for capacitative and non-capacitative Ca(2+) entry in smooth muscleRegulation of Ca(2+) entry pathways by both limbs of the phosphoinositide pathway; Discussion; Calcium release by ryanodine receptors in smooth muscle; Discussion; Organization of Ca(2+) stores in vascular smooth muscle: functional implications; Discussion; Molecular basis and physiological functions of dynamic Ca(2+) signalling in smooth muscle cells; Discussion; Calcium release events in excitation-contraction coupling in smooth muscle; Discussion 327 $aSarcoplasmic reticulum, calcium waves and myometrial signallingDiscussion; Sarcoplasmic reticulum and membrane currents; Discussion; Sarcoplasmic reticulum function and contractile consequences in ureteric smooth muscles; Discussion; General discussion II The physiological significance of smooth muscle Ca(2+) stores; The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice; Discussion; The sarcoplasmic reticulum in disease and smooth muscle dysfunction: therapeutic potential; Discussion; The sarcoplasmic reticulum: then and now; Discussion; Final general discussion 327 $aIndex of contributorsSubject index 330 $aSmooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to serious pathological conditions, such as hypertension and pre-term labour. The calcium ion plays a central role in smooth muscle function, increasing in concentration for contraction and decreasing for relaxation. Calcium entry into the cell is facilitated by the sarcoplasmic reticulum (SR). This book explores the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function. It examines the control and modulation of t 410 0$aNovartis Foundation symposium ;$v246. 606 $aSmooth muscle$vCongresses 606 $aSarcoplasmic reticulum$vCongresses 608 $aElectronic books. 615 0$aSmooth muscle 615 0$aSarcoplasmic reticulum 676 $a571.6/5 676 $a611.0186 701 $aChadwick$b Derek$091632 701 $aGoode$b Jamie$0283336 712 02$aNovartis Foundation. 712 12$aSymposium on Role of the Sarcoplasmic Reticulum in Smooth Muscle$f(2001 :$eNovartis Foundation) 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910143168203321 996 $aRole of the sarcoplasmic reticulum in smooth muscle$92246835 997 $aUNINA