LEADER 04719nam 2200661 a 450 001 9910142970203321 005 20170810190737.0 010 $a1-282-12347-5 010 $a9786612123474 010 $a1-4443-1209-X 010 $a0-470-74408-1 035 $a(CKB)1000000000754337 035 $a(EBL)428202 035 $a(OCoLC)437111802 035 $a(SSID)ssj0000360174 035 $a(PQKBManifestationID)11244193 035 $a(PQKBTitleCode)TC0000360174 035 $a(PQKBWorkID)10325762 035 $a(PQKB)10250771 035 $a(MiAaPQ)EBC428202 035 $a(EXLCZ)991000000000754337 100 $a20081119d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aFluorine in medicinal chemistry and chemical biology$b[electronic resource] /$fedited by Iwao Ojima 210 $aChichester ;$aHoboken $cWiley$d2009 215 $a1 online resource (658 p.) 300 $aDescription based upon print version of record. 311 $a0-470-74407-3 311 $a1-4051-6720-3 320 $aIncludes bibliographical references and index. 327 $aFluorine in Medicinal Chemistry and Chemical Biology; Contents; Preface; Contributors; Abbreviations; Introduction: Basic Aspects of Fluorine in Chemistry and Biology; 1: Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology; Medicinal Chemistry; 2: Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent; 3: Fluorinated Conformationally Restricted Glutamate Analogues for CNS Drug Discovery and Development; 4: Fluorinated Inhibitors of Matrix Metalloproteinases; 5: Fluoro-Taxoid Anticancer Agents 327 $a6: Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability7: Synthesis and Biological Activity of Fluorinated Nucleosides; Synthetic Methods for Medicinal Chemistry and Chemical Biology; 8: Synthesis of gem-Difluoromethylenated Nucleosides via gem-Difluoromethylene-containing Building Blocks; 9: Recent Advances in the Syntheses of Fluorinated Amino Acids; 10: Fluorinated Moieties for Replacement of Amide and Peptide Bonds; 11: Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery 327 $a12: gem-Difluorocyclopropanes as Key Building Blocks for Novel Biologically Active Molecules13: Fluorous Mixture Synthesis (FMS) of Drug-like Molecules and Enantiomers, Stereoisomers, and Analogues of Natural Products; 14: Fluorine-18 Radiopharmaceuticals; Applications of Fluorinated Amino Acids and Peptides to Chemical Biology and Pharmacology; 15: Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins; 16: Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology 327 $a17: Effects of Fluorination on the Bioorganic Properties of Methionine18: Structure Analysis of Membrane-Active Peptides Using 19F-labeled Amino Acids and Solid-State NMR; 19: Study of Metabolism of Fluorine-containing Drugs Using In Vivo Magnetic Resonance Spectroscopy; Appendix; Approved Active Pharmaceutical Ingredients Containing Fluorine; Section 1. Fluorine-containing Drugs for Human Use Approved by FDA in the United States; Section 2. Fluorine-containing Drugs for Veterinary Use Approved by FDA in the United States; Index; color plates 330 $aThe extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine 606 $aOrganofluorine compounds 606 $aFluorination$xPhysiological effect 606 $aBioorganic chemistry 606 $aPharmaceutical chemistry 608 $aElectronic books. 615 0$aOrganofluorine compounds. 615 0$aFluorination$xPhysiological effect. 615 0$aBioorganic chemistry. 615 0$aPharmaceutical chemistry. 676 $a615.19 676 $a615.27312 701 $aOjima$b Iwao$f1945-$092743 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910142970203321 996 $aFluorine in medicinal chemistry and chemical biology$92139763 997 $aUNINA