LEADER 04807nam 2200637Ia 450 001 9910142516403321 005 20170809164945.0 010 $a1-280-36679-6 010 $a9786610366798 010 $a0-470-30556-8 010 $a1-60119-515-X 010 $a0-471-23492-3 035 $a(CKB)111056485566910 035 $a(EBL)152097 035 $a(OCoLC)475871925 035 $a(SSID)ssj0000073111 035 $a(PQKBManifestationID)11107288 035 $a(PQKBTitleCode)TC0000073111 035 $a(PQKBWorkID)10102907 035 $a(PQKB)10097389 035 $a(MiAaPQ)EBC152097 035 $a(EXLCZ)99111056485566910 100 $a20020715d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aThermodynamics of pharmaceutical systems$b[electronic resource] $ean introduction for students of pharmacy /$fKenneth A. Connors 210 $aHoboken, N.J. $cWiley-Interscience$dc2002 215 $a1 online resource (358 p.) 300 $aDescription based upon print version of record. 311 $a0-471-46139-3 311 $a0-471-20241-X 320 $aIncludes bibliographical references (p. 333-335) and index. 327 $aTHERMODYNAMICS OF PHARMACEUTICAL SYSTEMS; CONTENTS; PREFACE; I BASIC THERMODYNAMICS; 1 Energy and the First Law of Thermodynamics; 1.1. Fundamental Concepts; 1.2. The First Law of Thermodynamics; 1.3. The Enthalpy; 2 The Entropy Concept; 2.1. The Entropy Defined; 2.2. The Second Law of Thermodynamics; 2.3. Applications of the Entropy Concept; 3 The Free Energy; 3.1. Properties of the Free Energy; 3.2. The Chemical Potential; 4 Equilibrium; 4.1. Conditions for Equilibrium; 4.2. Physical Processes; 4.3. Chemical Equilibrium; II THERMODYNAMICS OF PHYSICAL PROCESSES 327 $a5 Introduction to Physical Processes5.1. Scope; 5.2. Concentration Scales; 5.3. Standard States; 6 Phase Transformations; 6.1. Pure Substances; 6.2. Multicomponent Systems; 7 Solutions of Nonelectrolytes; 7.1. Ideal Solutions; 7.2. Nonideal Solutions; 7.3. Partitioning between Liquid Phases; 8 Solutions of Electrolytes; 8.1. Coulombic Interaction and Ionic Dissociation; 8.2. Mean Ionic Activity and Activity Coefficient; 8.3. The Debye-Hu?ckel Theory; 9 Colligative Properties; 9.1. Boiling Point Elevation; 9.2. Freezing Point Depression; 9.3. Osmotic Pressure; 9.4. Isotonicity Calculations 327 $a10 Solubility10.1. Solubility as an Equilibrium Constant; 10.2. The Ideal Solubility; 10.3. Temperature Dependence of the Solubility; 10.4. Solubility of Slightly Soluble Salts; 10.5. Solubilities of Nonelectrolytes: Further Issues; 11 Surfaces and Interfaces; 11.1. Thermodynamic Properties; 11.2. Adsorption; III THERMODYNAMICS OF CHEMICAL PROCESSES; 12 Acid-Base Equilibria; 12.1. Acid-Base Theory; 12.2. pH Dependence of Acid-Base Equilibria; 12.3. Calculation of Solution pH; 12.4. Acid-Base Titrations; 12.5. Aqueous Solubility of Weak Acids and Bases; 12.6. Nonaqueous Acid-Base Behavior 327 $a12.7. Acid-Base Structure and Strength13 Electrical Work; 13.1. Introduction; 13.2. Oxidation-Reduction Reactions; 13.3. Electrochemical Cells; 13.4. pH Measurement; 13.5. Ion-Selective Membrane Electrodes; 14 Noncovalent Binding Equilibria; 14.1. Introduction; 14.2. The Noncovalent Interactions; 14.3. Binding Models; 14.4. Measurement of Binding Constants; APPENDIXES; A Physical Constants; B Review of Mathematics; B.1. Introduction; B.2. Logarithms and Exponents; B.3. Algebraic and Graphical Analysis; B.4. Dealing with Change; B.5. Statistical Treatment of Data; B.6. Dimensions and Units 327 $aANSWERS TO PROBLEMSBIBLIOGRAPHY; INDEX 330 $aStudies of thermodynamics often fail to demonstrate how the mathematical intricacies of the subject relate to practical laboratory applications. Thermodynamics of Pharmaceutical Systems makes these connections clear, emphasizing specific applications to pharmaceutical systems in a study created specifically for contemporary curriculums at colleges of pharmacy. Students investigating drug discovery, drug delivery, and drug action will benefit from Kenneth Connors's authoritative treatment of the fundamentals of thermodynamics as well as his attention to drug molecules and experimental conside 606 $aPharmaceutical chemistry 606 $aThermodynamics 608 $aElectronic books. 615 0$aPharmaceutical chemistry. 615 0$aThermodynamics. 676 $a615.19 676 $a615/.19 700 $aConnors$b Kenneth A$g(Kenneth Antonio),$f1932-$066132 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910142516403321 996 $aThermodynamics of pharmaceutical systems$91926947 997 $aUNINA