LEADER 05223nam 2200637Ia 450 001 9910142500503321 005 20170809164957.0 010 $a1-280-36660-5 010 $a9786610366606 010 $a0-470-23184-X 010 $a0-471-46104-0 010 $a0-471-22387-5 035 $a(CKB)111056485584020 035 $a(EBL)469580 035 $a(OCoLC)52412971 035 $a(SSID)ssj0000182755 035 $a(PQKBManifestationID)11178522 035 $a(PQKBTitleCode)TC0000182755 035 $a(PQKBWorkID)10172400 035 $a(PQKB)10710091 035 $a(MiAaPQ)EBC469580 035 $a(EXLCZ)99111056485584020 100 $a20000525d2001 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 03$aAn introduction to molecular medicine and gene therapy$b[electronic resource] /$fedited by Thomas F. Kresina 210 $aNew York $cWiley-Liss$dc2001 215 $a1 online resource (408 p.) 300 $aDescription based upon print version of record. 311 $a0-471-39188-3 320 $aIncludes bibliographical references and index. 327 $aAN INTRODUCTION TO MOLECULAR MEDICINE AND GENE THERAPY; CONTENTS; Preface; Contributors; Chapter 1 Molecular Medicine and Gene Therapy: An Introduction; Introduction; Genetic Manifestations of Molecular Medicine; Gene Therapy and Patterns of Gene Expression; Gene Therapy and Molecular Medicine; Gene Therapy: Current Basic Science Issues; Human Gene Therapy: Current Status and Basic Science Research Needs; Gene Therapies: Next Horizon; Key Concepts; Suggested Readings; Chapter 2 Nuclear Transplantation and New Frontiers in Genetic Molecular Medicine; Background; Introduction 327 $aNuclear Transplantation: A Tool in Developmental BiologyTechnical Developments in Nuclear Transplantation; Defining the Limits of Nuclear Reprogramming in Mammals; Toward an Understanding of the Mechanisms of Genetic Reprogramming; Application of Genetic Reprogramming; Human Embroyonic Stem Cell Research: An Ethics Note; Summary; Key Concepts; Suggested Readings; Chapter 3 Builing a Better Mouse: Genetically Altered Mice as Models for Gene Therapy; Background; Introduction; Producing Mouse Models of Human Disease; Mouse Models for Gene Therapy: What Makes a Good Model of Human Disease? 327 $aModels of Monogenic DisordersModels of Polygenic and Multifactorial Disorders; Mouse Models of Molecular Therapeutics: Developing and Testing Gene Therapy Methodology; Generation of Chimeric Tissues; Human Cell Xenograft Models in Immunodeficient Mice; Mouse Models: The Next Generation; Key Concepts; Suggested Readings; Chapter 4 Vectors in Gene Therapy; Introduction; Viral Vectors Used for Gene Therapy; Retroviral Vectors; Adenoviral Vectors; Adenovirus-Associated Virus; Herpes Simplex Virus 1; Other Viral Vectors; Nonviral Vectors; Oligonucleotides; Key Concepts; Suggested Readings 327 $aChapter 5 Gene TargetingBackground and Challenges; Introduction of DNA into the Cell; Nonviral Transfer Vehicles; Gene Targeting; Recombinational and Repair Enzymes in Gene Targeting Efforts; Synthetic Oliogonucleotides as Tools for Targeting; Insertion of Fragments of DNA: Gene Disruption and Replacement; Gene Targeting Has Already Proven Useful; Gene Targeting: The Future; Key Concepts; Suggested Readings; Chapter 6 Gene Therapy for Hematological Disorders; Introduction; Requirements for Gene Transfer into Hematopoietic Cells 327 $aHematopoietic Stem and Progenitor Cells as Targets for Gene TherapyLymphocyte Gene Transfer; Current Problems and Future Directions; Summary; Key Concepts; Suggested Readings; Chapter 7 Gene Therapy for Liver Disease; Background; Introduction; General Principles for Hepatic Gene Therapy; Clinical Applications of Liver-Directed Gene Therapy; Summary; Key Concepts; Suggested Readings; Chapter 8 Gene Therapy in Cardiovascular Disease; Introduction; Genetic Manipulation of Cardiovascular Tissue; Gene Therapy of Restenosis; Gene Therapy for Angiogenesis; Gene Therapy of Vascular Grafts 327 $aGene Therapy for the Heart 330 $aGene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the appl 606 $aGene therapy 606 $aCellular therapy 608 $aElectronic books. 615 0$aGene therapy. 615 0$aCellular therapy. 676 $a616 676 $a616.042 701 $aKresina$b Thomas F.$f1954-$0955829 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910142500503321 996 $aAn introduction to molecular medicine and gene therapy$92163490 997 $aUNINA