LEADER 03521nam 2200589 450 001 9910142484203321 005 20170815115235.0 010 $a1-280-55444-4 010 $a9786610554447 010 $a0-470-35936-6 010 $a0-470-84238-5 010 $a0-470-85368-9 035 $a(CKB)111056485602268 035 $a(EBL)127935 035 $a(OCoLC)181838732 035 $a(SSID)ssj0000161335 035 $a(PQKBManifestationID)11155000 035 $a(PQKBTitleCode)TC0000161335 035 $a(PQKBWorkID)10198879 035 $a(PQKB)11211953 035 $a(MiAaPQ)EBC127935 035 $a(EXLCZ)99111056485602268 100 $a20160812h19991999 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGene therapy technologies, applications, and regulations $efrom laboratory to clinic /$fedited by Anthony Meager 210 1$aChichester, West Sussex, England :$cJohn Wiley & Sons, Ltd,$d1999. 210 4$dİ1999 215 $a1 online resource (439 p.) 300 $aDescription based upon print version of record. 311 $a0-471-96709-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aGene Therapy Technologies, Applications and Regulations; Contents; List of contributors; Preface; 1 Cationic Liposomes for Gene Therapy Applications; 2 DNA Condensation and Receptor-mediated Gene Transfer; 3 Retroviral Vectors; 4 Lentiviral Vectors; 5 Adenoviral Vectors; 6 Adeno-associated Viral Vectors; 7 Advances in Engineering HSV Vectors for Gene Transfer to the Nervous System; 8 Mammalian Artificial Chromosomes: Prospects for Gene Therapy; 9 Gene Therapy for Severe Combined Immunodeficiency; 10 Gene Therapy for Haemophilia; 11 Cystic Fibrosis: Gene Therapy Approaches 327 $a12 Therapeutic Approaches to Haemoglobinopathies13 Gene Therapy Approaches to Duchenne Muscular Dystrophy; 14 Lysosomal Storage Diseases; 15 Prospects for Gene Therapy of HIV Infections and AIDS; 16 The Development of the Regulatory Process in Europe for Biological Medicines: how it Affects Gene Therapy Products; 17 Development and Regulation of Gene Therapy Drugs in Germany; 18 The Transfer of Technology from the Laboratory to the Clinic: In process Controls and Final Product Testing; 19 Good Laboratory Practice in the Research and Development Laboratory 327 $a20 Facilities for Large-scale Production of Vectors Under GMP ConditionsAddendum; Index 330 $aGene Therapy Technologies, Applications and Regulations From Laboratory to Clinic Edited by Anthony Meager Division of Immunobiology, The National Institute for Biological Standards and Control, South Mimms, UK The development of gene-based technologies has been rapid over the past decade and has consequently resulted in a surge of interest in human gene therapy, the deliberate transfer of genes to somatic cells to cure or alleviate disease symptoms. Hundreds of clinical protocols involving variously designed vectors for efficient gene transfer have been developed. However, the use of such com 606 $aGene therapy 608 $aElectronic books. 615 0$aGene therapy. 676 $a616.042 676 $a616/.042 702 $aMeager$b Anthony 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910142484203321 996 $aGene therapy technologies, applications, and regulations$92132603 997 $aUNINA