LEADER 03968oam 2200901zu 450 001 9910142451003321 005 20210721060354.0 010 $a0-470-84667-4 010 $a9786610555529 010 $a1-280-55552-1 035 $a(CKB)111056485557300 035 $a(SSID)ssj0000127296 035 $a(PQKBManifestationID)11139982 035 $a(PQKBTitleCode)TC0000127296 035 $a(PQKBWorkID)10052088 035 $a(PQKB)10667672 035 $a(MiAaPQ)EBC4956311 035 $a(Au-PeEL)EBL4956311 035 $a(CaONFJC)MIL55552 035 $a(OCoLC)1024237670 035 $a(EXLCZ)99111056485557300 100 $a20160829d2001 uy 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aComplexity in biological information processing 205 $a1st ed. 210 31$a[Place of publication not identified]$cJohn Wiley$d2001 215 $a1 online resource (258 pages) 225 1 $aNovartis Foundation Symposia ;$vv.Vol. 239 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-471-49832-7 311 $a0-470-85186-4 330 $aMany human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets. This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems. * Explores the structural and temporal complexity in biological signalling. * Represents an unusual collocation of three different areas: immunology, cell signalling and neural networks. * Contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations. 410 0$aNovartis Foundation Symposia 606 $aBiochemical Processes 606 $aCell Physiological Processes 606 $aBiology 606 $aBiochemical Phenomena 606 $aBiological Science Disciplines 606 $aCell Physiological Phenomena 606 $aChemical Processes 606 $aChemical Phenomena 606 $aPhenomena and Processes 606 $aNatural Science Disciplines 606 $aDisciplines and Occupations 606 $aComputational Biology 606 $aSignal Transduction 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 606 $aBiophysics$2HILCC 608 $aElectronic books. 615 2$aBiochemical Processes 615 2$aCell Physiological Processes 615 2$aBiology 615 2$aBiochemical Phenomena 615 2$aBiological Science Disciplines 615 2$aCell Physiological Phenomena 615 2$aChemical Processes 615 2$aChemical Phenomena 615 2$aPhenomena and Processes 615 2$aNatural Science Disciplines 615 2$aDisciplines and Occupations 615 2$aComputational Biology 615 2$aSignal Transduction 615 7$aBiology 615 7$aHealth & Biological Sciences 615 7$aBiophysics 676 $a571.7 702 $aBock$b Gregory 702 $aGoode$b Jamie 801 0$bPQKB 906 $aBOOK 912 $a9910142451003321 996 $aComplexity in biological information processing$92248612 997 $aUNINA LEADER 05458nam 2200649 a 450 001 9910139247103321 005 20230803023826.0 010 $a1-118-45391-3 010 $a1-118-45392-1 010 $a1-118-45390-5 035 $a(CKB)2560000000103664 035 $a(EBL)1211930 035 $a(OCoLC)851315970 035 $a(SSID)ssj0000889622 035 $a(PQKBManifestationID)12438097 035 $a(PQKBTitleCode)TC0000889622 035 $a(PQKBWorkID)10876542 035 $a(PQKB)11405847 035 $a(OCoLC)868940046 035 $a(MiAaPQ)EBC1211930 035 $a(Au-PeEL)EBL1211930 035 $a(CaPaEBR)ebr10719155 035 $a(EXLCZ)992560000000103664 100 $a20150303d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDiseases and disorders of mineral metabolism$b[electronic resource] /$feditor, Clifford J. Rosen 205 $a8th ed. 210 $aIowa, U.S.A. $cWiley-Blackwell$d2013 215 $a1 online resource (1106 p.) 300 $aDescription based upon print version of record. 311 $a1-118-45388-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title page; Copyright page; Contents; Contributors; Primer Corporate Sponsors; Preface to the Eighth Edition of the Primer; About ASBMR; President's Preface; About the Companion Website; Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation; 1: Skeletal Morphogenesis and Embryonic Development; Early Skeletal Patterning; Craniofacial patterning; Axial patterning; Limb patterning; Embryonic Cartilage and Bone Formation; Chondrocyte Proliferation and Differentiation in The Developing Cartilage; Regulation of Chondrocyte Survival; Conclusions; References 327 $a2: Signal Transduction Cascades Controlling Osteoblast DifferentiationIntroduction; Runx2 and Osterix Transcription Factors; BMP Signaling; TGF-? Signaling; WNT Signaling; Hedgehog Signaling; PTH Signaling; IGF-1 Signaling; FGF Signaling; Notch Signaling; Concluding Remarks; Acknowledgments; References; 3: Osteoclast Biology and Bone Resorption; Cell Biology of The Osteoclast; Integrin Signaling; Small GTPases; Factors Regulating Osteoclast Formation And/Or Function; Proteins; Small molecules; Cell-Cell Interactions in Bone Marrow; Intracellular Signaling Pathways; Human Genetics; References 327 $a4: OsteocytesIntroduction; Osteocyte Ontogeny; Osteocytes as Orchestrators of Bone (Re)Modeling; Osteocyte Cell Death and Apoptosis; Osteocyte Modification of Their Microenvironment; Mechanosensation and Transduction; Role of Gap Junctions and Hemichannels in Osteocyte Communication; The Potential Role of Osteocytes in Bone Disease; Acknowledgment; References; 5: Connective Tissue Pathways That Regulate Growth Factors; Introduction; The Fibrillinopathies; Fibrillin Microfibrils; Regulation of Growth Factors by Fibrillin Microfibrils; Molecular Mechanisms Orchestrated on a Microfibril Scaffold 327 $aSummaryAbbreviations; References; 6: The Composition of Bone; Introduction; The Composite; The mineral; Collagen; Noncollagenous Proteins; Serum-derived proteins; Proteoglycans; Glycosylated proteins; Small integrin-binding ligand, N-glycosylated protein, and other glycoproteins with cell attachment activity; Gla-containing proteins; Other Components; References; 7: Assessment of Bone Mass and Microarchitecture in Rodents; Introduction; Radiographs; Peripheral Dual-Energy X-Ray Absorptiometry; Peripheral Quantitative Computed Tomography; Magnetic Resonance Imaging; Microcomputed Tomography 327 $aNanocomputed TomographyImaging Considerations; Voxel size and image resolution; Segmentation; Skeletal site and volume of interest; Calibration; Other considerations; Conclusions; References; 8: Animal Models: Genetic Manipulation; Introduction; Overexpression of Target Genes; Chondrocytes; Osteoblasts; Tendon and ligament; Osteoclasts; Advantages and disadvantages of overexpression approaches; Gene Targeting; Advantages and disadvantages of gene targeting; Tissue-Specific and Inducible Knockout and Overexpression; Uncondensed mesenchyme, mesenchymal condensations, and neural crest; Cartilage 327 $aOsteoblasts 330 $aPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.Primer on the Metabolic Bone Di 606 $aBones$xMetabolism$xDisorders 606 $aMineral metabolism$xDisorders 615 0$aBones$xMetabolism$xDisorders. 615 0$aMineral metabolism$xDisorders. 676 $a616.7/16 701 $aRosen$b Clifford J$0878534 712 02$aAmerican Society for Bone and Mineral Research. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139247103321 996 $aDiseases and disorders of mineral metabolism$91961465 997 $aUNINA