LEADER 05264nam 2200649Ia 450 001 9910141821803321 005 20200520144314.0 010 $a1-118-63733-X 010 $a1-118-63727-5 010 $a1-118-63730-5 035 $a(CKB)2670000000397652 035 $a(EBL)1319495 035 $a(OCoLC)854521191 035 $a(SSID)ssj0000950942 035 $a(PQKBManifestationID)11513238 035 $a(PQKBTitleCode)TC0000950942 035 $a(PQKBWorkID)10898666 035 $a(PQKB)10873725 035 $a(MiAaPQ)EBC1319495 035 $a(Au-PeEL)EBL1319495 035 $a(CaPaEBR)ebr10738074 035 $a(CaONFJC)MIL506231 035 $a(PPN)176047794 035 $a(EXLCZ)992670000000397652 100 $a20130114d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aViral hepatitis$b[electronic resource] /$fedited by Howard C. Thomas ... [et al.] 205 $a4th ed. 210 $aChichester, West Sussex $cJohn Wiley & Sons$dc2014 215 $a1 online resource (642 p.) 300 $aDescription based upon print version of record. 311 $a0-470-67295-1 320 $aIncludes bibliographical references and index. 327 $aCover; Title page; Copyright page; Contents; List of Contributors; Preface; Section I: Introduction to Liver Biology; Chapter 1: Liver regeneration and fibrosis; Introduction; Liver turnover and regeneration; Kinetic organization; Liver regeneration; Molecular regulation of liver regeneration; Stem cells and liver cancer (founders and propagators); Liver fibrosis; References; Chapter 2: Hepatic immunology; Overview of liver immunology; Innate immunity; Cell populations and mediators in the innate immune response; Inflammation in liver diseases; Adaptive immunity; CD4+ T cells; CD8+ T cells 327 $aRegulatory T cellsCD17; B cells; The liver is a unique immune organ; References; Section II: Hepatitis A Virus; Chapter 3: Structure, molecular virology, natural history, and experimental models; Introduction; HAV structure and molecular virology; Genomic structure; Translation, polyprotein processing, and protein function; Particle and antigen structure; Growth in cell culture; Viral receptors and cell entry; Replication and release of viral particles; Genetic diversity; Natural history of HAV; Association of HAV infection with the permanent modulation of immune responses 327 $aPathogenesis of HAVHAV experimental models; Conclusion; References; Chapter 4: Epidemiology and prevention; Epidemiology; Transmission; Seroprevalence; Molecular epidemiology; Conclusion: epidemiology; Prevention; Active immunization; Passive immunization; Future directions in hepatitis A prevention; Acknowledgment; References; Section III: Hepatitis B Virus and Other Hepadnaviridae; Chapter 5: Structure and molecular virology; HBV morphology, life cycle, and genome organization; Virion morphology: Dane particles; Overview of the HBV life cycle; Genomic structure and organization 327 $aHepatitis B viral proteinsHBV envelope proteins and HBsAg; Hepatitis B core protein; HBe proteins; Viral polymerase (Pol); The HBx protein; HBV life cycle; Infection study models; Attachment, membrane fusion, and entry; Attachment and infectivity; Formation of cccDNA; Integration of HBV DNA; Regulation of HBV DNA transcription; Translation; Genome replication and regulation; Amplification and stability of cccDNA; Conclusion; References; Chapter 6: Epidemiology and prevention; Epidemiology; Prevalence; Transmission; Infection and its complications; Populations at risk for infection 327 $aHepatitis B and specific settingsCo-infections; HBV genotypes; Prevention; Primary prevention through immunization; Passive immunization; Active immunization using hepatitis B vaccine; Global vaccination programs; Clinical and epidemiological impact of hepatitis B vaccination; Conclusion; References; Chapter 7: Other Hepadnaviridae (Avihepadnaviridae (DHBV) and Orthohepadnaviridae (WHV)); Hepadnaviridae: Introduction and comparative virology; Avihepadnaviridae: Classification; Avihepadnaviridae: The exogenous replication strategy 327 $aDevelopment of antihepadnaviral agents: The experimental model of DHBV 330 $a The 4th edition of Viral Hepatitis covers comprehensively the entire complex field of infections caused by all of the different hepatitis viruses, which affect many millions of people throughout the world with considerable morbidity and mortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from the USA and Stephen Locarnini from Australia as Editors. They have recruited leading researchers and physicians from many countries, who have produced an authoritative account of current knowledge and research on this important infection, including new insights i 606 $aHepatitis, Viral 606 $aHepatitis 615 0$aHepatitis, Viral. 615 0$aHepatitis. 676 $a616.3/623 701 $aThomas$b H. C$g(Howard C.)$0865324 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141821803321 996 $aViral hepatitis$91931415 997 $aUNINA