LEADER 05532nam 2200697 a 450 001 9910141649103321 005 20200520144314.0 010 $a1-118-50365-1 010 $a1-299-24263-4 010 $a1-118-50366-X 010 $a1-118-50367-8 035 $a(CKB)2670000000336897 035 $a(EBL)1132797 035 $a(OCoLC)820665779 035 $a(SSID)ssj0000832859 035 $a(PQKBManifestationID)11465907 035 $a(PQKBTitleCode)TC0000832859 035 $a(PQKBWorkID)10899670 035 $a(PQKB)10617597 035 $a(MiAaPQ)EBC1132797 035 $a(Au-PeEL)EBL1132797 035 $a(CaPaEBR)ebr10667388 035 $a(CaONFJC)MIL455513 035 $a(PPN)190978279 035 $a(EXLCZ)992670000000336897 100 $a20121206d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe chemistry of contrast agents in medical magnetic resonance imaging$b[electronic resource] /$fedited by Andre? E. Merbach, Lothar Helm, E?va To?th 205 $a2nd ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons Inc.$d2013 215 $a1 online resource (514 p.) 300 $aDescription based upon print version of record. 311 $a1-119-99176-5 320 $aIncludes bibliographical references and index. 327 $aCover; Title Page; Copyright; Contents; List of Contributors; Preface; Chapter 1 General Principles of MRI; 1.1 Introduction; 1.2 Theoretical basis of NMR; 1.2.1 Short description of NMR; 1.2.2 Relaxation times; 1.2.3 Saturation transfer; 1.2.4 Concept of localization by magnetic field gradients; 1.3 Principles of magnetic resonance imaging; 1.3.1 Spatial encoding; 1.4 MRI pulse sequences; 1.4.1 Definition; 1.4.2 k-Space trajectory; 1.4.3 Basic pulse sequences 327 $a1.5 Basic image contrast: Tissue characterization without injection of contrast agents (main contrast of an MRI sequence: Proton density (P), T_1 and T_2, T_2^*)1.5.1 Proton density weighting; 1.5.2 T1 weighting; 1.5.3 T2 weighting; 1.5.4 T2* weighting; 1.6 Main contrast agents; 1.6.1 Gadolinium (Gd) complex agents; 1.6.2 Iron oxide (IO) agents; 1.6.3 CEST agents; 1.7 Examples of specialized MRI pulse sequences for angiography (MRA); 1.7.1 Time of flight angiography: No contrast agent; 1.7.2 Angiography using intravascular contrast agent (Blood pool CA) injection; 1.7.3 DSC DCE MRI 327 $aReferencesChapter 2 Relaxivity of Gadolinium(III) Complexes: Theory and Mechanism; 2.1 Introduction; 2.2 Inner-sphere proton relaxivity; 2.2.1 Hydration number and hydration equilibria; 2.2.2 Gd-H distance; 2.2.3 Proton/water exchange; 2.2.4 Rotation; 2.3 Second- and outer-sphere relaxation; 2.4 Relaxivity and NMRD profiles; 2.4.1 Fitting of NMRD profiles; 2.4.2 Relaxivity of low-molecular-weight Gd(III) complexes; 2.4.3 Relaxivity of macromolecular MRI contrast agents; 2.4.4 Contrast agents optimized for application at high magnetic field; 2.5 Design of high relaxivity agents: Summary 327 $aReferencesChapter 3 Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes; 3.1 Introduction-general requirements for the ligands and complexes; 3.2 Contrast agents employing linear polyamine scaffold; 3.2.1 Synthesis of linear polyamine backbone; 3.2.2 N-functionalization of linear polyamine scaffold; 3.3 Contrast agents employing cyclen scaffold; 3.3.1 Synthesis of the macrocyclic skeleton; 3.3.2 N-functionalization of macrocyclic scaffold; 3.4 Other types of ligands; 3.4.1 H4TRITA and related ligands; 3.4.2 H3PCTA and related ligands; 3.4.3 TACN derivatives 327 $a3.4.4 Ligands with HOPO coordinating arms and related groups3.4.5 H4AAZTA and related ligands; 3.5 Bifunctional ligands and their conjugations; 3.6 Synthesis and characterization of the Ln(III) complexes; 3.6.1 General synthetic remarks; 3.6.2 Characterization of the complexes; List of Abbreviations; References; Chapter 4 Stability and Toxicity of Contrast Agents; 4.1 Introduction; 4.2 Equilibrium calculations 327 $a4.2.1 Constants that characterize metal ligand interactions (protonation constants of the ligands, stability constants of the complexes, conditional stability constants, ligand selectivity, and concentration of free Gd^3+: pM) 330 $a"The second edition of The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging is a comprehensive treaty covering all aspects of production, use, operating mechanism and theory of these diagnostic agents used to produce high contrast images in MRI.It has been completed to now include recent developments on "classical" Gd-based and iron-oxide probes and chapters dedicated to the most significant advances in molecular imaging probes. Chemical Exchange Saturation Transfer is discussed, which is a novel means of generating MRI contrast"--$cProvided by publisher. 606 $aContrast-enhanced magnetic resonance imaging 606 $aMagnetic resonance imaging 615 0$aContrast-enhanced magnetic resonance imaging. 615 0$aMagnetic resonance imaging. 676 $a616.07/548 686 $aSCI078000$2bisacsh 701 $aHelm$b Lothar$0943654 701 $aMerbach$b Andre? E$0943655 701 $aTo?th$b E?va$0685600 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141649103321 996 $aThe chemistry of contrast agents in medical magnetic resonance imaging$92130198 997 $aUNINA