LEADER 05535nam 2200673 a 450 001 9910141610703321 005 20200520144314.0 010 $a1-118-35596-2 010 $a1-299-24236-7 010 $a1-118-35594-6 035 $a(CKB)2670000000336251 035 $a(EBL)947698 035 $a(OCoLC)829462134 035 $a(SSID)ssj0000831903 035 $a(PQKBManifestationID)11501361 035 $a(PQKBTitleCode)TC0000831903 035 $a(PQKBWorkID)10880393 035 $a(PQKB)10746999 035 $a(MiAaPQ)EBC947698 035 $a(Au-PeEL)EBL947698 035 $a(CaPaEBR)ebr10662563 035 $a(CaONFJC)MIL455486 035 $a(PPN)223783544 035 $a(EXLCZ)992670000000336251 100 $a20120411d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEndocrine disrupters$b[electronic resource] $ehazard testing and assessment methods /$fedited by Peter Matthiessen 210 $aHoboken, N.J. $cWiley$d2013 215 $a1 online resource (412 p.) 300 $aDescription based upon print version of record. 311 $a0-470-93209-0 320 $aIncludes bibliographical references and index. 327 $aENDOCRINE DISRUPTERS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals : AN INTRODUCTION; 1.1 BACKGROUND; 1.2 REGULATORY CONCERNS; 1.3 INVERTEBRATES; 1.4 VERTEBRATES; 1.5 TESTING SCHEMES FOR EDCs; REFERENCE; CHAPTER 2 Endocrine Disruption in Wildlife : BACKGROUND, EFFECTS, AND IMPLICATIONS; 2.1 BACKGROUND TO ENDOCRINE DISRUPTION; 2.1.1 Introduction; 2.1.2 Brief Account of the History of Endocrine Disruption; 2.1.3 What Are Endocrine-Disrupting Chemicals?; 2.1.4 Vertebrate Endocrine System; 2.1.5 Invertebrate Endocrine System 327 $a2.1.6 Mechanisms of Endocrine Disruption2.1.7 Endocrine Disrupters in the Environment; 2.2 EFFECTS OF EDCs ON WILDLIFE; 2.2.1 Mammals; 2.2.2 Birds; 2.2.3 Reptiles and Amphibians; 2.2.4 Fish; 2.2.5 Invertebrates; 2.3 WEIGHT OF EVIDENCE AND ECOLOGICAL SIGNIFICANCE OF ED EFFECTS; 2.4 IMPLICATIONS FOR EFFECT ASSESSMENT AND TOXICITY TESTING; 2.5 NEED FOR MORE FIELD STUDIES AND AN INTEGRATED APPROACH; 2.6 CONCLUDING POINTS; REFERENCES; CHAPTER 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife 327 $a3.1 EMERGING CONCERNS AND POLICY RESPONSES: FOCUSING ON EDCs AS A LARGE PSEUDO-UNIFORM GROUP OF SUBSTANCES3.1.1 Regulatory Action Among Public Concern, Policy, Stakeholder Interests, and Scientific Complexity: The Starting Point; 3.1.2 Policy Responses to the Initial General Concern: General Strategies; 3.2 GENERAL APPROACHES IN SUBSTANCE-RELATED REGULATORY FRAMEWORKS (EU); 3.2.1 Highlighted Role of ED Properties in General Parts of Regulatory Frameworks; 3.2.2 REACH: Authorization in Cases of "Very High Concern" 327 $a3.2.3 Plant Protection Products: Major Change from Directive 91/414 to New Regulation 1107/20093.2.4 Biocides; 3.2.5 Pharmaceuticals; 3.2.6 Other Regulatory Frameworks Not Primarily Related to Substances; 3.3 HOW TO MAKE EDC DEFINITIONS OPERATIONAL FOR SUBSTANCE-RELATED REGULATORY WORK; 3.4 FUTURE PERSPECTIVES; 3.5 CONCLUSIONS; REFERENCES; CHAPTER 4 Techniques for Measuring Endocrine Disruption in Insects; 4.1 INTRODUCTION; 4.1.1 Insects; 4.1.2 Insect Hormones; 4.1.3 Endocrine Disruption and Insects; 4.1.4 Development of Insecticides Targeting the Endocrine System; 4.2 METHODS 327 $a4.2.1 Mechanistic Assays4.2.2 Apical Assays; 4.3 DISCUSSION; 4.3.1 Mechanism and Effect; 4.3.2 Exposure Considerations; 4.4 CONCLUSION; 4.5 ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 Crustaceans; 5.1 INTRODUCTION; 5.2 BACKGROUND TO CRUSTACEAN ENDOCRINOLOGY; 5.2.1 General; 5.2.2 Overview of the Crustacean Endocrine System; 5.3 STATE OF THE ART: WHAT DO WE KNOW ABOUT ENDOCRINE DISRUPTION IN CRUSTACEANS?; 5.3.1 General; 5.3.2 Daphnia sp.; 5.3.3 Barnacles; 5.3.4 Copepods; 5.3.5 Amphipods; 5.3.6 Mysids; 5.3.7 Other Studies Using Larger Crustaceans 327 $a5.4 AVAILABLE SUBCHRONIC/CHRONIC STANDARD TEST PROTOCOLS 330 $a"This book describes methodology and applications for endocrine disrupter toxicity testing, an issue of considerable urgency, because of international regulatory authorities currently considering such testing schemes. The coverage examines major animal groups for sensitivity to endocrine disrupting chemicals (EDCs), identifying endpoints and procedures for testing guidelines. Three EDC screening methods (two using fish and one using amphibians) are examined in detail for their efficacy and applicability. Edited by, and with contributions from, a leading participant in regulatory efforts, the book outlines methods that combine sensitivity, efficiency, statistical power, acceptable cost, and minimum ethical concern"--$cProvided by publisher. 606 $aEndocrine disrupting chemicals$xToxicity testing 606 $aEndocrine disrupting chemicals$xEnvironmental aspects 606 $aEndocrine toxicology 615 0$aEndocrine disrupting chemicals$xToxicity testing. 615 0$aEndocrine disrupting chemicals$xEnvironmental aspects. 615 0$aEndocrine toxicology. 676 $a615.3/6 686 $aSCI013060$2bisacsh 701 $aMatthiessen$b Peter$0445421 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141610703321 996 $aEndocrine disrupters$92032082 997 $aUNINA