LEADER 05254nam 2200637 a 450 001 9910141610003321 005 20200520144314.0 010 $a3-527-66541-2 010 $a3-527-66543-9 010 $a3-527-66542-0 035 $a(CKB)2670000000353838 035 $a(EBL)1180946 035 $a(OCoLC)843202395 035 $a(SSID)ssj0001004751 035 $a(PQKBManifestationID)11636374 035 $a(PQKBTitleCode)TC0001004751 035 $a(PQKBWorkID)11047172 035 $a(PQKB)11112172 035 $a(MiAaPQ)EBC1180946 035 $a(MiAaPQ)EBC4044467 035 $a(Au-PeEL)EBL1180946 035 $a(CaPaEBR)ebr10694933 035 $a(PPN)178272639 035 $a(EXLCZ)992670000000353838 100 $a20130521d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPost-transcriptional gene regulation$b[electronic resource]$eRNA processing in eukaryotes /$fedited by Jane Wu 210 $aWest Sussex, England $cWiley-Blackwell$dc2013 215 $a1 online resource (278 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32202-7 320 $aIncludes bibliographical references and index. 327 $aCover; Related Titles; Title page; Copyright page; Contents; Foreword; List of Contributors; 1: The Role of Cotranscriptional Recruitment of RNA-Binding Proteins in the Maintenance of Genomic Stability; 1.1 Introduction; 1.2 THO/TREX; 1.2.1 THO/TREX in Saccharomyces cerevisiae; 1.2.2 THO/TREX in Higher Eukaryotes; 1.2.3 THO/TREX and R-loop Formation; 1.3 Linking Transcription to Export of mRNP; 1.3.1 The Thp1-Sac3-Sus1-Cdc31 (THSC) Complex; 1.3.2 SR Proteins; 1.3.3 The Exon Junction Complex; 1.3.4 The Exosome; 1.4 Cotranscriptional R-loop Formation; 1.4.1 R-loops in Escherichia coli 327 $a1.4.2 Naturally Occurring R-loops1.4.3 TREX Protects against R-loop Formation; 1.4.4 SR Proteins Protect against R-loop Formation; 1.5 R-loop-induced Double-Stranded (ds) DNA Breaks; 1.5.1 Class Switch Recombination; 1.5.2 Formation of Double-Strand Breaks; 1.5.3 Rrm3 and Pif1 DNA Helicases; 1.6 Concluding Remarks; References; 2: Transcription Termination by RNA Polymerase II; 2.1 Messenger RNA Gene Termination; 2.1.1 The Allosteric Model; 2.1.2 The Torpedo Model; 2.2 Small Nucleolar RNA Gene Termination Pathway; 2.3 Choice between the Two Termination Pathways 327 $a2.4 Regulation of Transcription by Termination2.4.1 Transcription Attenuation, Promoter Upstream/Associated Transcription, and Pausing of RNApII; 2.4.2 Alternative Polyadenylation and Termination; 2.5 Mechanisms of Termination by Other RNA Polymerases; 2.6 Future Perspectives; Acknowledgments; References; 3: Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing; 3.1 Introduction; 3.2 The RNA Editing Kinship; 3.3 The ADAR Gene Family; 3.4 The Role of RNA in the A-to-I Editing Mechanism; 3.5 Splice Site Alterations 327 $a3.6 A-to-I RNA Recoding Modifies Proteins Such As Neurotransmitters3.6.1 Glutamate Receptor Editing - GluR-B; 3.6.2 Serotonin Receptor Editing - 5-HT2CR; 3.7 Cellular Effects and in Vivo Phenotypes of ADAR Gene Inactivation; 3.8 Noncoding RNA and Repetitive Sequences; 3.9 Effects on the RNA Interference Silencing Pathway; 3.10 Effects on MicroRNA Processing and Target Selection; 3.11 RNA Editing Role as an Antiviral Mechanism; 3.12 Conclusions; Acknowledgments; References; 4: Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP Assembly and Germ Line Specification 327 $a4.1 Introduction4.2 Protein Methylation - Flavors and Functions; 4.3 Sm Proteins Contain sDMA- and aDMA-Modified Arginines; 4.4 SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and Spinal Muscular Atrophy (SMA); 4.5 PRMT5 and PRMT7 - The Sm Protein Methyltransferases; 4.6 Sm Protein Methylation is Required for sn/RNP Assembly in Mammals; 4.7 Sm Protein Methylation in Drosophila; 4.8 Unresolved Questions: Sm Protein Methylation and snRNP Assembly; 4.9 Conclusion - The Evolution of snRNP Assembly; 4.10 Sm Proteins Are Required for Germ Cell Specification 327 $a4.11 Dart5, Valois, Sm Proteins, and Tudor Anchoring 330 $aReflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry. 606 $aGenetic regulation 606 $aEukaryotic cells 615 0$aGenetic regulation. 615 0$aEukaryotic cells. 676 $a572.865 701 $aWu$b Jane$0970045 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141610003321 996 $aPost-transcriptional gene regulation$92204991 997 $aUNINA