LEADER 01109nam0-2200325---450- 001 990009764310403321 005 20130925151029.0 010 $a978-88-6611-183-2 035 $a000976431 035 $aFED01000976431 035 $a(Aleph)000976431FED01 035 $a000976431 100 $a20130925d2012----km-y0itay50------ba 101 0 $aita 102 $aIT 105 $ay-------001yy 200 1 $aDiritto di asilo e nuove esigenze di protezione internazionale nell'Unione europea$fGiuseppina Pizzolante 210 $aBari$cCacucci$d2012 215 $a231 p.$d23 cm 225 1 $aCollana della 2. Facoltà di giurisprudenza$fUniversità degli studi di Bari Aldo Moro, sede di Taranto$v26 610 0 $aDiritto d'asilo$aLegislazione comunitaria 676 $a342.24083$v22$zita 700 1$aPizzolante,$bGiuseppina$0509149 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a990009764310403321 952 $aUniv. 303 (26)$b49990$fFSPBC 959 $aFSPBC 996 $aDiritto di asilo e nuove esigenze di protezione internazionale nell'Unione europea$9834833 997 $aUNINA LEADER 09677nam 2200625 a 450 001 9910141530703321 005 20200520144314.0 010 $a1-118-49524-1 010 $a1-283-97811-3 010 $a1-118-49521-7 010 $a1-118-49523-3 035 $a(CKB)2670000000316489 035 $a(EBL)1104493 035 $a(OCoLC)823389931 035 $a(SSID)ssj0000804008 035 $a(PQKBManifestationID)11488894 035 $a(PQKBTitleCode)TC0000804008 035 $a(PQKBWorkID)10811559 035 $a(PQKB)11720205 035 $a(MiAaPQ)EBC1104493 035 $a(DLC) 2017285041 035 $a(Au-PeEL)EBL1104493 035 $a(CaPaEBR)ebr10648817 035 $a(CaONFJC)MIL429061 035 $a(PPN)196480019 035 $a(EXLCZ)992670000000316489 100 $a20120904d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHydrophilic interaction chromatography$b[electronic resource] $ea guide for practitioners /$fedited by Bernard A. Olsen, Brian W. Pack 210 $aHoboken, N.J. $cJohn Wiley & Sons, Inc.$d2013 215 $a1 online resource (337 p.) 225 1 $aChemical analysis : a series of monographs on analytical chemistry and its applications ;$vv. 177 300 $aDescription based upon print version of record. 311 $a1-118-05417-2 320 $aIncludes bibliographical references and index. 327 $aMachine generated contents note: Chapter 1. Separation Mechanisms in Hydrophilic Interaction Chromatography 1.1 Introduction 1.2 Historical Background. Recognition of the contribution of partition, ion exchange and reversed-phase interactions to the retention process 1.3 Recent studies on the contributory mechanisms to HILIC retention 1.3.1 Overview 1.3.2 Contribution of adsorption and partition to HILIC separations 1.3.3 Further studies on the contribution of ionic retention in HILIC 1.3.3.1 Introduction 1.3.3.2 Mobile phase considerations for the separation of ionogenic compounds 1.3.3.3. Ionisation state of the column as a function of pH 1.3.3.4 Quantitation of ionic retention effects on different columns 1.3.4 Reversed-phase retention on bare silica 1.3.5 Electrostatic Repulsion Hydrophilic Interaction Chromatography (ERLIC)- a new separation mode in HILIC. 1.4 Conclusions Chapter 2. Stationary Phases for HILIC 2.1 Introduction 2.2 HILIC stationary phases 2.2.1 Underivatized silica 2.2.1.1 Totally porous silica particles 2.2.1.2 Superficially porous (core shell) silica particles 2.2.1.3 Monolithic silica 2.2.1.4 Ethylene Bridged Hybrids (BEH) 2.2.2 Derivatized silica 2.2.2.1 Neutral derivatized silica 2.2.2.2 Zwitterionic derivatized silica 2.2.2.3 Positively charged derivatized silica 2.2.2.4 Negatively charged derivatized silica 2.2.3 Non-silica phases 2.2.3.1 Amino phases 2.2.3.2 Sulfonated S-DVB phases 2.3 Commercial HILIC phases 2.3.1 Efficiency comparison 2.3.2 Retention and selectivity comparisons 2.4 Conclusions Chapter 3. HILIC Method Development 3.1 Introduction 3.2 General method development considerations 3.2.1 Method objectives 3.2.2 Sample consideration 3.2.3 Systematic method development 3.3 Method development strategies 3.3.1 Systematic approach to column screening 3.3.2 Optimization of method parameters 3.3.2.1 Final column selection 3.3.2.2 Organic solvents 3.3.2.3 Mobile phase pH 3.3.2.4 Buffer types and concentration 3.3.2.5 Column temperature 3.3.2.6 Sample solvents 3.4 Detection for HILIC methods 3.4.1 Mass Spectrometry detector (MS) 3.4.2 Charged aerosol detector (CAD) 3.5 Conclusions Chapter 4. Pharmaceutical Applications of Hydrophilic Interaction Chromatography 4.1 Introduction 4.1.1 Definition of the problem 4.1.2 Selection of conditions 4.1.3 Validation of the method 4.1.4 General references 4.2 Determination of Counterions 4.2.1 Salt selection and options for counterion determination 4.2.2 Specific counterion analysis 4.2.3 Counterion screening with gradient elution 4.2.4 Suitable reference standards for counterion analysis 4.3 Main Component Methods 4.3.1 Potency/assay methods 4.3.2 Equipment cleaning verification assays 4.3.3 Dissolution methods 4.4 Determination of Impurities 4.4.1 Impurity screening and orthogonal separations 4.4.2 Impurity identification 4.4.3 Specific impurity determination 4.4.3.1 Pyrimidines, purines, nucleosides 4.4.3.2 Hydrazines with ethanol as weak solvent 4.4.3.3 Neutral and charged polar impurities in a drug substance 4.4.3.4 Polar basic compounds and impurities 4.4.4 Statistical design of experiments (DOE) for optimization 4.5 Excipients 4.5.1 Parenteral and solution formulations 4.5.2 Tablets, capsules and inhalation products 4.5.3 Sugars 4.5.4 Stabilizers and antioxidants 4.6 Chiral Applications 4.6.1 Chiral selectors and HILIC 4.6.1.1 Cyclodextrins 4.6.1.2 Macrocyclic antibiotics 4.6.1.3 Chiral crown ethers 4.6.1.4 Cyclofructans 4.6.2 Conclusions for chiral separations 4.7 Conclusions Chapter 5. Hydrophilic Interaction Chromatography (HILIC) for Drug Discovery 5.1 Drug Discovery Model 5.2 HILIC Applications for in vitro Biology 5.2.1 Biological screening and hit finding 5.2.1.1 Target selection and assay validation 5.2.1.2 High-throughput screening 5.2.2 New drug discovery strategies 5.3 HILIC Applications and Advances for Discovery Chemistry 5.3.1 Lead identification 5.3.2 Lead optimization 5.3.2.1 ADME profile 5.3.2.2 Biopharmaceutics 5.3.2.3 Chiral purity 5.3.3 Candidate selection 5.4 Practical Considerations 5.5 Conclusions Chapter 6. Advances in Hydrophilic Interaction Chromatography (HILIC) for Biochemical Applications 6.1 Introduction 6.2 Carbohydrates 6.2.1 Mono- and disaccharides 6.2.2 Oligosaccharides and polysaccharides 6.2.3 Glycans 6.2.3.1 Glycan and glycopeptide analysis 6.2.3.2 HILIC for sample enrichment 6.3 Nucleobases and Nucleosides 6.4 Oligonucleotides 6.5 Amino Acids and Peptides 6.6 Proteins 6.7 Phospholipids 6.8 Conclusions Chapter 7. HILIC-MS for Targeted Metabolomics and Small Molecule Bioanalysis 7.1 Introduction 7.2 The role of HILIC-MS in targeted metabolomics versus other LC modes 7.3 Strategies for method development based on retention behavior of targeted metabolites on HILIC stationary phases 7.3.1 Retention behavior of metabolites on HILIC stationary phases 7.3.2 Robustness, mobile phase compositions, and matrix effects 7.4 Summary Chapter 8. HILIC for Food, Environmental, and Other Applications 8.1 Introduction 8.2 Food applications for HILIC 8.2.1 Review of HILIC analytical methods for food analysis 8.2.1.1 Sample preparation in HILIC methods applied to food matrices 8.2.1.2 HILIC methods applied to food matrices: chromatographic parameters and detection 8.2.2 Selected detailed examples of HILIC applications in food analysis 8.2.2.1 Melamine (MEL) and cyanuric acid (CYA) 8.2.2.2 Water soluble vitamins 8.2.2.3 Seafood and other toxins 8.3 Environmental and other applications of HILIC 8.3.1 Review of environmental applications based on the stages of method development 8.3.2 Selected detailed examples of environmental and other HILIC applications 8.3.2.1 Metals and their related organic compounds 8.3.2.2 Pharmaceutical compounds in aqueous environmental samples 8.3.2.3 Other applications 8.4 Conclusions Chapter 9. Theory and Practice of Two-Dimensional Liquid Chromatography Separations Involving the HILIC Mode of Separation 9.1 Fundamentals of multi-dimensional liquid chromatography 9.1.1 Scope 9.1.2 Potential advantages of two-dimensional separations over conventional separations 9.1.3 Modes of 2D separation 9.1.3.1 Offline fraction transfer 9.1.3.2 Online fraction transfer 9.1.3.3 Conceptual comparison of different 2D separation modes 9.1.4 Undersampling 9.1.5 Orthogonality 9.2 Complementarity of HILIC selectivity to other separation modes 9.3 Instrumentation and Experimental Considerations 9.3.1 Online versus offline 2DLC 9.3.1.1 Offline 2DLC 9.3.1.2 Online 2DLC 9.3.2 Dealing with solvent incompatibility 9.3.2.1 Partial mobile phase evaporation 9.3.2.2 Consideration of fraction transfer volume relative to the second dimension column volume 9.3.2.3 On-column focusing 9.3.3 Fast Separations 9.3.3.1 General considerations for fast LC separations 9.3.3.2 Fast HILIC separations 9.4 Applications 9.5 The future of HILIC separations in 2DLC. 330 $a"This book provides background information, guidance for method development, and a discussion of applications in the field of hydrophilic interaction chromatography (HILIC.) The book serves as a valuable reference tool for scientists confronted with an analysis problem involving polar compounds to determine if HILIC would be a good choice to pursue and helps them in choosing initial experimental conditions. The book gives a detailed description of the HILIC retention mechanisms and specific information regarding application areas spanning a wide range of industries.Topics include: HILIC retention mechanisms, Stationary Phases for HILIC, HILIC Method Development, Pharmaceutical and Other Applications of HILIC, HILIC for Drug Discovery, HILIC in Two-Dimensional Separations"--$cProvided by publisher. 410 0$aChemical analysis ;$vv. 177. 606 $aHydrophilic interaction liquid chromatography 615 0$aHydrophilic interaction liquid chromatography. 676 $a543/.84 686 $aSCI013010$2bisacsh 701 $aOlsen$b Bernard A.$f1953-$0951057 701 $aPack$b Brian W.$f1970-$0951058 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141530703321 996 $aHydrophilic interaction chromatography$92150093 997 $aUNINA LEADER 00964nam a2200265 i 4500 001 991000726869707536 005 20020509174627.0 008 010514s1958 de ||| | ger 035 $ab11401084-39ule_inst 035 $aPARLA214094$9ExL 040 $aDip.to Filosofia$bita 082 0 $a200.1 100 1 $aMarx, Karl$032587 245 10$aUber Religion /$cKarl Marx, Friedrich Engels 260 $aBerlin :$bDietz,$c1958 300 $a360 p. ;$c21 cm. 500 $aIn testa al front.: Institut für Marxismus-Leninismus bein ZK der SED 650 4$aReligione 700 1 $aEngels, Friedrich$eauthor$4http://id.loc.gov/vocabulary/relators/aut$036926 907 $a.b11401084$b02-04-14$c01-07-02 912 $a991000726869707536 945 $aLE005IF XXVI F 3$g1$iLE005IFA-2097$lle005$o-$pE0.00$q-$rl$s- $t0$u0$v0$w0$x0$y.i11588214$z01-07-02 996 $aUber Religion$91451168 997 $aUNISALENTO 998 $ale005$b01-01-01$cm$da $e-$fger$gde $h0$i1 LEADER 04044nam 2200721 450 001 9910827575703321 005 20230807213749.0 010 $a3-11-041969-6 010 $a3-11-041980-7 024 7 $a10.1515/9783110419696 035 $a(CKB)3710000000359880 035 $a(EBL)1867290 035 $a(SSID)ssj0001457441 035 $a(PQKBManifestationID)11822859 035 $a(PQKBTitleCode)TC0001457441 035 $a(PQKBWorkID)11441470 035 $a(PQKB)11257582 035 $a(DE-B1597)450534 035 $a(OCoLC)908080236 035 $a(OCoLC)979746213 035 $a(DE-B1597)9783110419696 035 $a(MiAaPQ)EBC1867290 035 $a(Au-PeEL)EBL1867290 035 $a(CaPaEBR)ebr11049380 035 $a(CaONFJC)MIL783518 035 $a(EXLCZ)993710000000359880 100 $a20150511h20152015 uy 0 101 0 $ager 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aErza?hltheorie in media?vistischer Perspektive $eStudienausgabe /$fArmin Schulz ; herausgegeben von Manuel Braun, Alexandra Dunkel, Jan-Dirk Mu?ller 205 $a2., durchgesehene Auflage. 210 1$aBerlin, [Germany] ;$aMunich, [Germany] ;$aBoston, [Massachusetts] :$cDe Gruyter,$d2015. 210 4$d©2015 215 $a1 online resource (448 p.) 225 0 $aDe Gruyter Studium 300 $aDescription based upon print version of record. 311 $a3-11-040014-6 320 $aIncludes bibliographical references and index. 327 $t Frontmatter -- $tVorwort zur Studienausgabe -- $tVorbemerkung -- $tInhalt -- $t1. Vorwort -- $t2. Interpretation und Anthropologie: Konzeptionen von Figuren und ihren Interaktionen -- $t3. Vom mittelalterlichen Wiedererz•hlen: Narrative Gattungen im Widerstreit konkurrierender Logiken -- $t4. Erzählen nach Mustern: Die gängigsten mittelalterlichen Erzählschemata -- $t5. Räume und Zeiten -- $t6. Verknüpfungen: Wie wird ein Text zu einem kohärenten Text? -- $t7. Vermittler zwischen Stoff und Rezipient: Erzähler und Erzählperspektive -- $tLiteratur -- $tAutoren- und Textregister 330 $aDass die Erzähltheorie zu historisieren sei, ist immer wieder gefordert worden. Im Bereich vormoderner und besonders mittelalterlicher Literatur gibt es inzwischen eine schwer überschaubare Fülle von Einzelstudien, die überzeugende Zugänge gefunden haben, um die mitunter befremdliche Andersheit der Narration zu begreifen und für weiter gehende Textinterpretationen zu nutzen. Die Erzähltheorie in mediävistischer Perspektive unternimmt den erstmaligen Versuch, die vorhandenen Ansätze zu bündeln und fortzuführen, daneben auch Lücken in der bislang erarbeiteten Systematik aufzufüllen. Von besonderem Interesse sind die Semantiken, die über das Erzählen vermittelt werden: in impliziten Gattungsentwürfen, Erzählschemata, gängigen Themen und Motivkomplexen, Bezügen zum zeitgenössischen kulturellen Wissen, Raum- und Zeitkonzeptionen, Verknüpfungsregeln, Erzählerentwürfen. Die Erzähltheorie in mediävistischer Perspektive hat sich innerhalb kurzer Zeit als handbuchartiges Überblickswerk für narratologisch interessierte Mediävisten und fortgeschrittene Studierende etabliert und liegt nun als durchgesehene Studienausgabe vor. 410 3$aDe Gruyter Studium 606 $aNarration (Rhetoric) 606 $aNarration (Rhetoric)$xHistory$yTo 1500 606 $aLiterature, Medieval$xHistory and criticism 615 0$aNarration (Rhetoric) 615 0$aNarration (Rhetoric)$xHistory 615 0$aLiterature, Medieval$xHistory and criticism. 676 $a808/.036 686 $aGE 7200$2rvk 700 $aSchulz$b Armin$f1966-2010,$01700783 702 $aBraun$b Manuel 702 $aDunkel$b Alexandra 702 $aMu?ller$b Jan-Dirk 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910827575703321 996 $aErza?hltheorie in media?vistischer Perspektive$94084061 997 $aUNINA