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010   $a1-280-58934-5
010   $a9786613619174
010   $a1-118-28603-0
010   $a1-118-28606-5
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035   $a(OCoLC)787842654
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100   $a20111026d2012      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aAbsorption and drug development $esolubility, permeability, and charge state /$fAlex Avdeef
205   $a2nd ed.
210   $aHoboken, N.J. $cJohn Wiley & Sons$dc2012
215   $a1 online resource (742 p.)
300   $aDescription based upon print version of record.
311   $a1-118-28596-4 
311   $a1-118-05745-7 
320   $aIncludes bibliographical references and index.
327   $aIntroduction -- Transport model -- pKa determination -- Octanol-water partitioning -- Liposome-water partitioning -- Solubility -- Permeability - Pampa -- Permeability Caco 2/MDCK -- Permeability blood brain barrier.
330   $a Explains how to perform and analyze the results of the latest physicochemical methods  With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates.  Th
606   $aDrugs$xDesign
606   $aDrugs$xMetabolism
606   $aDrug development
606   $aAbsorption
615  0$aDrugs$xDesign.
615  0$aDrugs$xMetabolism.
615  0$aDrug development.
615  0$aAbsorption.
676   $a615/.19
700   $aAvdeef$b Alex$0521357
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910141449403321
996   $aAbsorption and drug development$9836551
997   $aUNINA