LEADER 03448nam 2200637 a 450 001 9910141265303321 005 20240516121009.0 010 $a1-280-59219-2 010 $a9786613622020 010 $a1-118-31030-6 010 $a1-118-31031-4 010 $a1-118-31029-2 035 $a(CKB)2670000000207459 035 $a(EBL)861782 035 $a(OCoLC)793995949 035 $a(SSID)ssj0000633033 035 $a(PQKBManifestationID)11463197 035 $a(PQKBTitleCode)TC0000633033 035 $a(PQKBWorkID)10616636 035 $a(PQKB)10831355 035 $a(MiAaPQ)EBC861782 035 $a(Au-PeEL)EBL861782 035 $a(CaPaEBR)ebr10643085 035 $a(CaONFJC)MIL362202 035 $a(PPN)176959769 035 $a(EXLCZ)992670000000207459 100 $a20111205d2012 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCancer as a metabolic disease$b[electronic resource] $eon the origin, management, and prevention of cancer /$fThomas N. Seyfried 205 $a1st ed. 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2012 215 $a1 online resource (472 p.) 300 $aDescription based upon print version of record. 311 $a0-470-58492-0 320 $aIncludes bibliographical references and index. 327 $aImages of cancer -- Confusion surrounds the origin of cancer -- Cancer models -- Energetics of normal cells and cancer cells -- Respiratory dysfunction in cancer cells -- The Warburg dispute -- Is respiration normal in most cancer cells? -- Is mitochondrial glutamine fermentation the missing link in the metabolic theory of cancer? -- Genes, respiration, viruses, and cancer -- Respiratory injury, the retrograde response, and the origin of cancer -- Mitochondria: the ultimate tumor suppressor -- Linking abnormalities in growth control, telomerase activity, apoptosis, and angiogenesis to mitochondrial dysfunction -- Metastasis -- Mitochondrial respiratory dysfunction and the extrachromosomal origin of cancer -- Nothing in cancer biology makes sense except in the light of evolution -- Cancer treatment strategies -- Metabolic management of cancer -- Implementation of metabolic therapies for cancer management -- Cancer prevention -- Case studies and personal experiences in using the ketogenic diet for cancer management. 330 $aThe book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the ""hallmarks of cancer"" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requiring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. 606 $aCancer 606 $aCancer$xPrevention 606 $aCancer$xDiagnosis 615 0$aCancer. 615 0$aCancer$xPrevention. 615 0$aCancer$xDiagnosis. 676 $a616.99/40654 700 $aSeyfried$b Thomas N.$f1946-$0521864 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141265303321 996 $aCancer as a metabolic disease$9838091 997 $aUNINA