LEADER 02977nam 2200589 a 450 001 9910141014803321 005 20200520144314.0 010 $a0-470-92272-9 010 $a1-283-07223-8 010 $a9786613072238 010 $a0-470-90991-9 010 $a0-470-90990-0 035 $a(CKB)2670000000077520 035 $a(EBL)675049 035 $a(OCoLC)729724611 035 $a(SSID)ssj0000486499 035 $a(PQKBManifestationID)11311190 035 $a(PQKBTitleCode)TC0000486499 035 $a(PQKBWorkID)10441936 035 $a(PQKB)11188861 035 $a(MiAaPQ)EBC675049 035 $a(Au-PeEL)EBL675049 035 $a(CaPaEBR)ebr10454749 035 $a(CaONFJC)MIL307223 035 $a(PPN)182413926 035 $a(EXLCZ)992670000000077520 100 $a20100507d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPharmaceutical toxicology in practice$b[electronic resource] $ea guide for non-clinical development /$fedited by Alberto Lodola, Jeanne Stadler 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2011 215 $a1 online resource (268 p.) 300 $aDescription based upon print version of record. 311 $a0-470-37137-4 320 $aIncludes bibliographical references and index. 327 $aThe regulatory environment / Claudio Bernardi and Marco Brughera --Toxicological development : roles and responsibilities / Franck Chuzel and Bernard Ruty -- Contract research organizations / Maurice Cary -- Safety pharmacology / Claudio Arrigoni and Valeria Perego -- Formulations, impurities and toxicokinetics / Claude Charuel -- General toxicology / Alberto Lodola -- Genetic toxicology / Peggy Guzzie-Peck, Jennifer Sasaki, and Sandy Weiner -- Developmental and reproductive toxicology / Jeanne Stadler -- Data analysis, report writing and regulatory documentation / Monique Y. Wells -- Risk management / Alberto Lodola. 330 $aThis book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in t 606 $aDrugs$xToxicity testing 615 0$aDrugs$xToxicity testing. 676 $a615/.7040724 701 $aLodola$b Alberto$0942115 701 $aStadler$b Jeanne$0942116 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910141014803321 996 $aPharmaceutical toxicology in practice$92125758 997 $aUNINA LEADER 03108oam 2200697I 450 001 9910970533203321 005 20251116232941.0 010 $a1-135-12708-5 010 $a0-203-07672-9 010 $a1-299-28055-2 010 $a1-135-12709-3 024 7 $a10.4324/9780203076729 035 $a(CKB)2560000000099355 035 $a(EBL)1143780 035 $a(OCoLC)830161240 035 $a(SSID)ssj0000833148 035 $a(PQKBManifestationID)12419808 035 $a(PQKBTitleCode)TC0000833148 035 $a(PQKBWorkID)10935354 035 $a(PQKB)10095351 035 $a(OCoLC)833299033 035 $a(MiAaPQ)EBC1143780 035 $a(Au-PeEL)EBL1143780 035 $a(CaPaEBR)ebr10672754 035 $a(CaONFJC)MIL459305 035 $a(OCoLC)862105454 035 $a(FINmELB)ELB134292 035 $a(EXLCZ)992560000000099355 100 $a20180706d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEnvironmental regulation and compulsory public disclosure $ethe case of PROPER in Indonesia /$fShakeb Afsah. [et al.] 205 $a1st ed. 210 1$aAbingdon, Oxon :$cRFF Press,$d2013. 215 $a1 online resource (150 p.) 225 1 $aResources for the future 225 1 $aEnvironment for development 300 $aDescription based upon print version of record. 311 08$a1-138-57313-2 311 08$a0-415-65765-2 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Public disclosure in developing countries -- Institutional history of Indonesia's environmental rating and public disclosure program -- Rating methodology and implementation -- The effectiveness of PROPER -- Which firms were more sensitive to proper? -- How does PROPER work? -- The impact of the financial crisis on PROPER -- Current status of proper (2001-2011) -- Summary and conclusions. 330 $aThis book is a remarkable case study of an environmental policy initiative for a national environmental regulatory system in the information age. In 1995 the Indonesian Ministry of Environment took the bold step to launch an environmental disclosure initiative called the Program for Pollution Control, Evaluation and Rating (PROPER). Under PROPER, environmental performance of companies is mapped into a five-color grading scale - Gold for excellent, Green for very good, Blue for good, Red for non-compliance, and Black for causing environmental damage. These ratings are then publicly disclosed 410 0$aEnvironment for development. 410 0$aResources for the future. 606 $aEnvironmental policy$zIndonesia 606 $aDisclosure of information$zIndonesia 615 0$aEnvironmental policy 615 0$aDisclosure of information 676 $a363.73/609598 701 $aAfsah$b Shakeb$01881926 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910970533203321 996 $aEnvironmental regulation and compulsory public disclosure$94496836 997 $aUNINA