LEADER 04118nam 2200613Ia 450 001 9910140948203321 005 20170924235612.0 010 $a3-527-63211-5 010 $a1-282-78384-X 010 $a9786612783845 010 $a3-527-63019-8 010 $a3-527-63020-1 035 $a(CKB)2670000000048613 035 $a(EBL)584989 035 $a(OCoLC)701311255 035 $a(SSID)ssj0000426043 035 $a(PQKBManifestationID)11294772 035 $a(PQKBTitleCode)TC0000426043 035 $a(PQKBWorkID)10372545 035 $a(PQKB)10720383 035 $a(MiAaPQ)EBC584989 035 $a(EXLCZ)992670000000048613 100 $a20080901d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPrinciples and practice of mixtures toxicology$b[electronic resource] /$fedited by Moiz Mumtaz; with a foreword by John Doull 210 $aWeinheim $cWiley-VCH$d2010 215 $a1 online resource (663 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31992-1 320 $aIncludes bibliographical references and index. 327 $aPrinciples and Practice of Mixtures Toxicology; Foreword; Contents; Preface; List of Contributors; 1 Introduction to Mixtures Toxicology and Risk Assessment; 2 Chemical Mixtures in the Environment: Exposure Assessment; 3 Application of a Relative Potency Factor Approach in the Assessment of Health Risks Associated with Exposures to Mixtures of Dioxin-Like Compounds; 4 Statistical Methods in Risk Assessment of Chemical Mixtures; 5 Modeling Kinetic Interactions of Chemical Mixtures; 6 Toxicodynamic Interactions; 7 Toxicological Interaction Thresholds of Chemical Mixtures 327 $a8 Characterization of Toxicoproteomics Maps for Chemical Mixtures Using Information Theoretic Approach9 Pharmacokinetic Mechanisms of Interactions in Chemical Mixtures; 10 Chemical Mixtures and Cumulative Risk Assessment; 11 Application of ATSDR.s Mixtures Guidance for the Toxicity Assessment of Hazardous Waste Sites; 12 Application of Mixture Methodology for Workplace Exposures; 13 Assessing Risk of Drug Combinations; 14 Dermal Chemical Mixtures; 15 Synergy: A Risk Management Perspective; 16 Chemistry, Toxicity, and Health Risk Assessment of Drinking Water Disinfection By-Products 327 $a17 Endocrine Active Chemicals18 Evaluation of Interactions in Chemical Mixtures; 19 Thyroid-Active Environmental Pollutants and Their Interactions on the Hypothalamic-Pituitary-Thyroid Axis; 20 Toxic and Genotoxic Effects of Mixtures of Polycyclic Aromatic Hydrocarbons; 21 Development of In Vitro Models to Assess Toxicity of Engineered Nanomaterials; 22 The Application of Physiologically Based Pharmacokinetics, Bayesian Population PBPK Modeling, and Biochemical Reaction Network Modeling to Chemical Mixture Toxicology; 23 Food Ingredients are Sometimes Mixtures; 24 Biomonitoring 327 $a25 Adverse Drug Reactions and InteractionsIndex 330 $aThis first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology. The practical handbook addresses all areas where toxic mixtures are encountered, from environmental via occupational to medical settings, giving special consideration to air and water, and to the specific requirements for study design in mixture toxicology. While no extensive prior knowledge or toxicological experience is required, the practice-oriented case studies and examples in the second part make this the ideal companion for the professional toxicologist in in 606 $aMixtures$xToxicology 606 $aToxicological chemistry 608 $aElectronic books. 615 0$aMixtures$xToxicology. 615 0$aToxicological chemistry. 676 $a615.9 676 $a615.902 701 $aMumtaz$b Moiz$0969182 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140948203321 996 $aPrinciples and practice of mixtures toxicology$92202098 997 $aUNINA