LEADER 05013nam 2200709Ia 450 001 9910140872203321 005 20201125182229.0 010 $a1-4443-4829-9 010 $a1-282-91417-0 010 $a9786612914171 010 $a1-4443-2733-X 010 $a1-4443-2734-8 035 $a(CKB)2670000000060751 035 $a(EBL)624715 035 $a(OCoLC)700701783 035 $a(MiAaPQ)EBC624715 035 $a(EXLCZ)992670000000060751 100 $a20100317d2011 uy 0 101 0 $aeng 135 $aur|n||||||||| 200 00$aGenetic and molecular aspects of sport performance$b[electronic resource] /$fedited by Claude Bouchard and Eric P. Hoffman 210 $aChichester, West Sussex [England] ;$aHoboken, NJ $cWiley-Blackwell$d2011 215 $a1 online resource (420 p.) 225 1 $aEncyclopaedia of sports medicine ;$vv. 18 300 $a"An IOC Medical Commission publication." 311 $a1-4443-3445-X 320 $aIncludes bibliographical references and index. 327 $aGenetic and Molecular Aspects of Sport Performance; Contents; List of Contributors; Foreword; Preface; Part 1 The Science of Genomics and Genetics; 1 The Human Genome and Epigenome; 2 Mitochondrial Medicine in Health and Disease: Interface Between Athletic Performance and Therapeutics; 3 Characterizing the Extent of Human Genetic Variation for Performance-Related Traits; 4 Current Proteome Profiling Methods; 5 Bioinformatics and Public Access Resources; 6 Search for Genes Influencing Complex Traits; Part 2 Evidence from Genetic Epidemiology Studies 327 $a7 Genetic Epidemiology, Physical Activity, and Inactivity8 Role of Genetics Factors in Sport Performance: Evidence from Family Studies; 9 Twin Studies in Sport Performance; 10 Twin and Family Studies of Training Responses; 11 Ethnic Differences in Sport Performance; 12 Selection Experiments in Rodents to Define the Complexity and Diversity of Endurance Capacity; Part 3 Contributions of Specific Genes and Markers; 13 Genes and Endurance Performance; 14 Genes and Strength and Power Phenotypes; 15 Genes and Response to Training 327 $a16 Genetic Determinants of Exercise Performance: Evidence from Transgenic and Null Mouse Models17 The ACE Gene and Performance; 18 The ACTN3 Gene and Human Performance; 19 Mitochondrial DNA Sequence Variation and Performance; 20 Genes, Exercise, and Lipid Metabolism; 21 Genes, Exercise, and Glucose and Insulin Metabolism; 22 Genes, Exercise, and Cardiovascular Phenotypes; 23 Genes, Exercise, and Protein Metabolism; 24 The Regulation of Physical Activity by Genetic Mechanisms: Is There a Drive to Be Active?; 25 Genes, Exercise, and Psychological Factors 327 $aPart 4 Systems Biology of Exercise and Training26 A Primer on Systems Biology, as Applied to Exercise Physiology and Metabolism; 27 Systems Biology Through Time Series Data-A Strength of Muscle Remodeling; 28 Proteomics in Exercise Training Research; 29 The Influence of Physical Exercise on Adult Stem Cells; Part 5 Ethical and Societal Implications; 30 Genetics and Ethics in Elite Sport; 31 Genes and Talent Selection; 32 Performance Enhancement by Gene Doping; 33 Bioethical Concerns in a Culture of Human Enhancement; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W 327 $aXY; Z 330 $aThis is the latest volume in the IOC Encyclopaedia of Sports Medicine series, summarizing the evidence from all relevant sources on the genetic and molecular basis of sports and other human physical performance. The initial chapters address the basic science of genomics and genetics and the regulation of gene expression. Additional chapters provide authoritative information on the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons. 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