LEADER 02640nam 2200505 n 450 001 996390943703316 005 20200824121505.0 035 $a(CKB)4940000000099779 035 $a(EEBO)2240879087 035 $a(UnM)99830320e 035 $a(UnM)99830320 035 $a(EXLCZ)994940000000099779 100 $a19950721d1682 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 04$aThe antient usage in bearing of such ensigns of honour as are commonly call'd arms$b[electronic resource] $eWith a catalogue of the present nobility of England. By Sir William Dugdale knt. Garter principal King of Arms. To which is added, A catalogue of the present nobility of Scotland and Ireland, &c 210 $aOxford $cprinted at the Theater, for Rich. Davis bookseller in Oxford$d1682 215 $a[8], 64, [4], p.7, [1], 67-78, [4], 79-210 p., [1] folded plate $cill. (woodcuts), table 300 $aWith a preliminary advertisment on pi1v, addenda and errata on A2. 300 $aDivisional titles read: "A true and perfect catalogue of the nobility of England" (p. [165] F1); "A catalogue of the baronets of this kingdom of England" (F8); "A true and perfect catalogue of the nobility of Scotland" (M5); "A true and perfect catalogue of the nobility of Ireland" (N6). 300 $a"A catalogue of books printed at the Theater in Oxford, .. " (pp. 194-210) begins with a caption title. 300 $aSignatures F and G have missigned leaves, printed out of order. 300 $aIllustrated with woodcuts of coats of arms, and a table of the Knights of the Garter of 1681. 300 $aCopy has MS. annotation at foot of A1v: "Sir. Wm. D. was buried 12 Februar. 1685. in Shustoke Church near Coleshill Co. Warwick". 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Nassar 210 $aHoboken, N.J. $cJohn Wiley & Sons$d2010 215 $a1 online resource (342 p.) 300 $aDescription based upon print version of record. 311 $a0-470-50478-1 320 $aIncludes bibliographical references and index. 327 $aBIOTRANSFORMATION AND METABOLITE ELUCIDATION OF XENOBIOTICS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: HUMAN BIOTRANSFORMATION; CHAPTER 2: ANALYTICAL TOOLS AND APPROACHES FOR METABOLITE IDENTIFICATION IN DRUG METABOLISM; CHAPTER 3: TOOLS OF CHOICE FOR ACCELERATING METABOLITE IDENTIFICATION: MASS SPECTROMETRY TECHNOLOGY DRIVES METABOLITE IDENTIFICATION STUDIES FORWARD; CHAPTER 4: IMPROVING DRUG DESIGN: CONSIDERATIONS FOR THE STRUCTURAL MODIFICATION PROCESS 327 $aCHAPTER 5: CASE STUDY: THE UNANTICIPATED LOSS OF N2 FROM NOVEL DNA ALKYLATING AGENT LAROMUSTINE BY COLLISION-INDUCED DISSOCIATION: NOVEL REARRANGEMENTSCHAPTER 6: CASE STUDY: IDENTIFICATION OF IN VITRO METABOLITE/DECOMPOSITION PRODUCTS OF THE NOVEL DNA ALKYLATING AGENT LAROMUSTINE; CHAPTER 7: STRATEGIES FOR THE DETECTION OF REACTIVE INTERMEDIATES IN DRUG DISCOVERY AND DEVELOPMENT; CHAPTER 8: SAFETY TESTING OF DRUG METABOLITES: MIST GUIDANCE IMPACT ON THE PRACTICE OF INDUSTRIAL DRUG METABOLISM; INDEX 330 $aThe goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tool 606 $aXenobiotics$xMetabolism 606 $aMetabolites$vIdentification 606 $aBiotransformation (Metabolism) 615 0$aXenobiotics$xMetabolism. 615 0$aMetabolites 615 0$aBiotransformation (Metabolism) 676 $a615.9 701 $aNassar$b Ala F$0913129 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140760703321 996 $aBiotransformation and metabolite elucidation of xenobiotics$92045589 997 $aUNINA