LEADER 03550nam 2200613Ia 450 001 9910140753403321 005 20230725025123.0 010 $a1-282-84953-0 010 $a9786612849534 010 $a3-527-63234-4 010 $a3-527-63199-2 010 $a3-527-63200-X 035 $a(CKB)2670000000048021 035 $a(EBL)589285 035 $a(SSID)ssj0000434349 035 $a(PQKBManifestationID)11281646 035 $a(PQKBTitleCode)TC0000434349 035 $a(PQKBWorkID)10402054 035 $a(PQKB)10796084 035 $a(MiAaPQ)EBC589285 035 $a(OCoLC)714797095 035 $a(EXLCZ)992670000000048021 100 $a20100630d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChemokine receptors as drug targets /$fedited by Martine J. Smit, Sergio A. Lira, and Rob Leurs 210 $aWeinheim, Germany $cWiley-VCH$dc2011 215 $a1 online resource (410 p.) 225 1 $aMethods and principles in medicinal chemistry ;$vv. 46 300 $aDescription based upon print version of record. 311 $a3-527-32118-7 320 $aIncludes bibliographical references and index. 327 $aChemokine Receptors as Drug Targets; Contents; List of Contributors; Preface; A Personal Foreword; Part One: Fundamentals of Chemokines and Chemokine Receptors; 1 Structural Aspects of Chemokines and their Interactions with Receptors and Glycosaminoglycans; 2 Structural Insights for Homology Modeling of Chemokine Receptors; 3 Signaling Events Involved in Chemokine-Directed T Lymphocyte Migration; 4 The Atypical Chemokine Receptors; 5 Targeting Chemokine Receptor Dimers: Are there Two (or More) to Tango?; Part Two: Chemokine Receptors in Disease; 6 Chemokine Receptors in Inflammatory Diseases 327 $a7 Chemokines and their Receptors in Central Nervous System Disease8 Chemokines and Cancer Metastasis; 9 Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis; Part Three: Targeting Chemokine Receptors; 10 CCR5 Antagonists in HIV; 11 CXCR4 as a Therapeutic Target; 12 Low Molecular Weight CXCR2 Antagonists as Promising Therapeutics; 13 Therapeutic Targeting of the CXCR3 Receptor; 14 Targeting CCR1; 15 Targeting CCR3; 16 Chemokine Binding Proteins as Therapeutics; Index 330 $aChemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities.Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in hu 410 0$aMethods and principles in medicinal chemistry ;$vv. 46. 606 $aChemokines$xReceptors$xEffect of drugs on 606 $aCell receptors 615 0$aChemokines$xReceptors$xEffect of drugs on. 615 0$aCell receptors. 676 $a616.079 701 $aSmit$b Martine J$0896412 701 $aLira$b Sergio A$0896413 701 $aLeurs$b Rob$0896414 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140753403321 996 $aChemokine receptors as drug targets$92002602 997 $aUNINA