LEADER 05059nam 2200637Ia 450 001 9910140705003321 005 20170809163711.0 010 $a1-283-14048-9 010 $a9786613140487 010 $a3-527-63051-1 010 $a3-527-63052-X 035 $a(CKB)2670000000019030 035 $a(EBL)530468 035 $a(OCoLC)644165941 035 $a(SSID)ssj0000420205 035 $a(PQKBManifestationID)11281469 035 $a(PQKBTitleCode)TC0000420205 035 $a(PQKBWorkID)10385948 035 $a(PQKB)11227544 035 $a(MiAaPQ)EBC530468 035 $a(iGPub)WILEYB0028491 035 $a(PPN)150324766 035 $a(EXLCZ)992670000000019030 100 $a20091203d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIdeas in chemistry and molecular sciences$iWhere chemistry meets life$b[electronic resource] /$fedited by Bruno Pignataro 205 $a1st ed. 210 $aWeinheim $cWiley-VCH$d2010 215 $a1 online resource (359 p.) 300 $aDescription based upon print version of record. 311 $a3-527-32541-7 320 $aIncludes bibliographical references and index. 327 $aIdeas in Chemistry and Molecular Sciences; Contents; 5.2.6.1 Streptavidin-Biotin; Preface; List of Contributors; Part I Biochemical Studies; 1 The Role of Copper Ion and the Ubiquitin System in Neurodegenerative Disorders; 1.1 Introduction; 1.2 Metal Ions in the Brain; 1.3 Brain Copper Homeostasis; 1.4 Brain Copper and Neurodegenerative Disorders; 1.5 The Role of Ubiquitin in Protein Degradation; 1.6 Failure of the Ubiquitin System in Neurodegenerative Disorders; 1.7 Interaction of Ubiquitin with Metal Ions; 1.7.1 Thermal Stability of Ubiquitin 327 $a1.7.2 Spectroscopic Characterization of CuII Binding1.7.3 Possible Implications for the Polyubiquitination Process; 1.7.4 CuII-Induced Self-Oligomerization of Ub; 1.7.5 Cooperativity between CuII-Binding and Solvent Polarity; 1.7.6 Comparison with Other Metal Ions; 1.8 Biological Implications; 1.8.1 The Redox State of Cellular Copper; 1.8.2 Ubiquitin and Phospholipids; 1.9 Conclusions and Perspectives; Acknowledgments; References; 2 The Bioinorganic and Organometallic Chemistry of Copper(III); 2.1 Introduction; 2.2 Bioinorganic Implications of Copper(III) 327 $a2.2.1 Dinuclear Type-3 Copper Enzymes2.2.2 Particulate Methano Monooxygenase (pMMO); 2.2.3 Mononuclear Monooxygenating Copper-based Enzymes; 2.2.4 Trinuclear Copper Models for Laccase; 2.3 Organometallic CuIII Species in Organic Transformations; 2.3.1 C-C Bond Formation in Organocuprate(I) Catalysis; 2.3.1.1 Conjugate Addition to ?-Enones; 2.3.1.2 Acetylene Carbocupration; 2.3.1.3 SN2 and SN2 Alkylations; 2.3.2 Aryl-Heteroatom Bond Formation in Cu-mediated Cross-coupling Processes; 2.3.3 Aromatic and Aliphatic C-H Bond Organometallic Functionalizations; 2.3.3.1 Catalytic Systems 327 $a2.3.3.2 Stoichiometric Systems2.4 Miscellany: Cuprate Superconducting Materials; 2.5 Overview and Future Targets; References; 3 Chemical Protein Modi.cation; 3.1 Introducing Diversity by Posttranslational Modification; 3.2 Chemistry: A Route to Modi.ed Proteins; 3.3 Challenges in Chemical Protein Modification; 3.4 Traditional Methods for Protein Modification; 3.4.1 Lysine Modi.cation; 3.4.1.1 Activated Esters; 3.4.1.2 Isocyanates and Isothiocyanates; 3.4.1.3 Reductive Alkylation; 3.4.1.4 IME Reagents; 3.4.2 Glutamic and Aspartic Acid Modification; 3.4.3 Cysteine; 3.4.3.1 Alkylation 327 $a3.4.3.2 Disulfides3.4.3.3 Desulfurization at Cysteine; 3.5 Recent Innovations in Site-Selective Protein Modification; 3.5.1 Dehydroalanine: A Useful Chemical Handle for Protein Conjugation; 3.5.2 Metal-Mediated Protein Modification; 3.5.2.1 Modification at Natural Residues; 3.5.2.2 Iridium-Catalyzed Reductive Alkylation of Lysine; 3.5.2.3 Modification of Unnatural Residues; 3.5.2.4 Olefin Metathesis at S-Allyl Cysteine; 3.5.3 Metal-Free Methods for Modifying Unnatural Amino Acids; 3.5.3.1 Oxime Ligation at Aldehydes and Ketones; 3.5.3.2 Azide and Alkyne Modification 327 $a3.5.3.3 Selective Modification of Tetrazole-Containing Proteins 330 $aIdeas in Chemistry and Molecular Sciences gives an account of the most recent results of research in life sciences in Europe based on a selection of leading young scientists participating in the 2008 European Young Chemists Award competition. In addition to this, the authors provide the state of the art of their field of research and the perspective or preview of future directions. 606 $aMolecular theory 606 $aChemistry$xSocial aspects 615 0$aMolecular theory. 615 0$aChemistry$xSocial aspects. 676 $a541.22 701 $aPignataro$b Bruno$0931664 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140705003321 996 $aIdeas in chemistry and molecular sciences$92111217 997 $aUNINA