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010   $a1-282-55159-0
010   $a9786612551598
010   $a0-470-58828-4
010   $a0-470-58827-6
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035   $a(OCoLC)587063581
035   $a(SSID)ssj0000367271
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035   $a(PQKBTitleCode)TC0000367271
035   $a(PQKBWorkID)10418481
035   $a(PQKB)10611745
035   $a(MiAaPQ)EBC487637
035   $a(Au-PeEL)EBL487637
035   $a(CaPaEBR)ebr10366682
035   $a(CaONFJC)MIL255159
035   $a(OCoLC)495594915
035   $a(FINmELB)ELB178856
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100   $a20091223d2010      uy         0
101 0 $aeng
135   $aurcn|||||||||
181   $ctxt
182   $cc
183   $acr
200 00$aVanilloid receptor TRPV1 in drug discovery $etargeting pain and other pathological disorders /$fedited by Arthur Gomtsyan, Connie R. Faltynek
205   $a1st ed.
210   $aHoboken, NJ $cWiley$dc2010
215   $a1 online resource (486 p.)
300   $aDescription based upon print version of record.
311   $a0-470-17557-5 
320   $aIncludes bibliographical references and index.
327   $aVANILLOID RECEPTOR TRPV1 IN DRUG DISCOVERY; CONTENTS; PREFACE AND ACKNOWLEDGMENTS; FOREWORD; CONTRIBUTORS; PART I INTRODUCTION TO THE TRP CHANNELS; 1 TRP Channels and Human Diseases; 2 Role of TRP Channels in Pain: An Overview; 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals; 4 TRPV1 Genetics; PART II ROLE FOR TRPV1 IN PAIN STATES; 5 TRPV1 and Inflammatory Pain; 6 Role of TRPV1 Receptors in Osteoarthritic Pain; 7 TRPV1 and Bone Cancer Pain; 8 TRPV1 in Visceral Pain and Other Visceral Disorders; 9 TRPV1 Receptors and Migraine
327   $a10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS; 11 Aryl-Urea Class and Related TRPV1 Antagonists; 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists; 13 TRPV1 Agonist Approaches for Pain Management; PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION; 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?; 15 The Role of TRPV1 in Respiratory Diseases; 16 The Role of TRPV1 in Diabetes; AFTERWORD
327   $aINDEX
330   $aExamines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it ""the holy grail"" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1
606   $aAnalgesics
606   $aDrugs$xDesign
606   $aNociceptors
606   $aInflammation
615  0$aAnalgesics.
615  0$aDrugs$xDesign.
615  0$aNociceptors.
615  0$aInflammation.
676   $a615.783
676   $a615/.783
701   $aGomtsyan$b Arthur$0978875
701   $aFaltynek$b Connie R$0978876
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910140620103321
996   $aVanilloid receptor TRPV1 in drug discovery$92231132
997   $aUNINA