LEADER 03722nam 2200709Ia 450 001 9910140620103321 005 20200520144314.0 010 $a1-282-55159-0 010 $a9786612551598 010 $a0-470-58828-4 010 $a0-470-58827-6 035 $a(CKB)2670000000009572 035 $a(EBL)487637 035 $a(OCoLC)587063581 035 $a(SSID)ssj0000367271 035 $a(PQKBManifestationID)11923653 035 $a(PQKBTitleCode)TC0000367271 035 $a(PQKBWorkID)10418481 035 $a(PQKB)10611745 035 $a(MiAaPQ)EBC487637 035 $a(Au-PeEL)EBL487637 035 $a(CaPaEBR)ebr10366682 035 $a(CaONFJC)MIL255159 035 $a(OCoLC)495594915 035 $a(FINmELB)ELB178856 035 $a(EXLCZ)992670000000009572 100 $a20091223d2010 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aVanilloid receptor TRPV1 in drug discovery $etargeting pain and other pathological disorders /$fedited by Arthur Gomtsyan, Connie R. Faltynek 205 $a1st ed. 210 $aHoboken, NJ $cWiley$dc2010 215 $a1 online resource (486 p.) 300 $aDescription based upon print version of record. 311 $a0-470-17557-5 320 $aIncludes bibliographical references and index. 327 $aVANILLOID RECEPTOR TRPV1 IN DRUG DISCOVERY; CONTENTS; PREFACE AND ACKNOWLEDGMENTS; FOREWORD; CONTRIBUTORS; PART I INTRODUCTION TO THE TRP CHANNELS; 1 TRP Channels and Human Diseases; 2 Role of TRP Channels in Pain: An Overview; 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals; 4 TRPV1 Genetics; PART II ROLE FOR TRPV1 IN PAIN STATES; 5 TRPV1 and Inflammatory Pain; 6 Role of TRPV1 Receptors in Osteoarthritic Pain; 7 TRPV1 and Bone Cancer Pain; 8 TRPV1 in Visceral Pain and Other Visceral Disorders; 9 TRPV1 Receptors and Migraine 327 $a10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS; 11 Aryl-Urea Class and Related TRPV1 Antagonists; 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists; 13 TRPV1 Agonist Approaches for Pain Management; PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION; 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?; 15 The Role of TRPV1 in Respiratory Diseases; 16 The Role of TRPV1 in Diabetes; AFTERWORD 327 $aINDEX 330 $aExamines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it ""the holy grail"" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 606 $aAnalgesics 606 $aDrugs$xDesign 606 $aNociceptors 606 $aInflammation 615 0$aAnalgesics. 615 0$aDrugs$xDesign. 615 0$aNociceptors. 615 0$aInflammation. 676 $a615.783 676 $a615/.783 701 $aGomtsyan$b Arthur$0978875 701 $aFaltynek$b Connie R$0978876 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140620103321 996 $aVanilloid receptor TRPV1 in drug discovery$92231132 997 $aUNINA