LEADER 04596nam 2200637Ia 450 001 9910140612503321 005 20200520144314.0 010 $a1-282-49198-9 010 $a9786612491986 010 $a1-4443-1965-5 010 $a1-4443-1966-3 035 $a(CKB)2670000000013698 035 $a(EBL)496049 035 $a(OCoLC)632158152 035 $a(SSID)ssj0000358046 035 $a(PQKBManifestationID)11254517 035 $a(PQKBTitleCode)TC0000358046 035 $a(PQKBWorkID)10359187 035 $a(PQKB)10669752 035 $a(MiAaPQ)EBC496049 035 $a(Au-PeEL)EBL496049 035 $a(CaPaEBR)ebr10373039 035 $a(CaONFJC)MIL249198 035 $a(PPN)198234732 035 $a(EXLCZ)992670000000013698 100 $a20091104d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe colors of mice$b[electronic resource] $ea model genetic network /$fM. Lynn Lamoreux ... [et al.] 210 $aChichester, West Sussex ;$aHoboken, NJ $cWiley-Blackwell$d2010 215 $a1 online resource (311 p.) 300 $aDescription based upon print version of record. 311 $a1-4051-7954-6 320 $aIncludes bibliographical references and index. 327 $aThe Colors of Mice; Contents; Preface; Acknowledgments; Statement regarding the use of pictures; Statement regarding nomenclature; Part I Introduction to the Pigmentary System; 1 Introduction to the Pigmentary System; 1.1 Introduction; 1.2 Colors of vertebrate animals; 1.3 Other pigment cells; 1.4 The epidermal melanin unit; 1.5 Mammalian hair; 1.6 Melanosome biogenesis and translocation; 1.7 Melanin; 1.8 Hair growth; 1.9 Hair growth cycles; 1.10 Embryonic development of the pigment cell lineage; 1.11 Pigment cells in culture; 1.12 Conclusion; Appendix: color loci of the mouse 327 $aPart II The Pigmentary Loci2 Introduction to Mutant Pigmentary Genes; 2.1 Defects of normal melanocyte development: white spotting and graying with age; 2.2 Defects in normal melanosome development: albinism; 2.3 Transport of melanosomes to other cells: the 'dilute' phenotype; 2.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis; 3 White Spotting and Progressive Graying; 3.1 Definitions and general background; 3.2 Pigment-cell development: developmental biology; 3.3 Cellular signaling pathways for melanocytes; 3.4 Pigment phenotypes and the classical white-spotting genes 327 $a3.5 The head, heart, ears, and eyes4 'Albinism' and the Failure of Normal Melanosome Maturation; 4.1 Background; 4.2 The melanosomal matrix; 4.3 The enzymes that catalyze melanogenesis; 4.4 Membrane proteins that regulate the internal milieu of the melanosome; 4.5 Protein processing and routing to the maturing melanosome; 4.6 Melanosome transport; 5 Pigment-Type Switching; 5.1 Introduction; 5.2 Yellow phenotypes; 5.3 Melanin pigment; 5.4 Melanogenesis and the eumelanin/pheomelanin switch mechanism; 5.5 Signaling the switch mechanism at the cellular level; 5.6 Yellow genes 327 $aPart III Technology and Resources6 Novel Mouse Pigmentary Mutants Generated by Genetic Manipulation; 6.1 Introduction; 6.2 Mouse transgenesis: generation of genetically engineered mice; 6.3 Coat-color transgenic mice; 6.4 The coat-color mutants generated by gene targeting; 6.5 Influence of the genetic background; 6.6 Conclusions; 7 Other Species and Other Resources; 7.1 Introduction; 7.2 Resources; 7.3 Other species; References; Index 330 $aServing the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellular 606 $aMice$xColor$xGenetics 606 $aMice as laboratory animals 615 0$aMice$xColor$xGenetics. 615 0$aMice as laboratory animals. 676 $a572.591935 676 $a599.35/3138 701 $aLamoreux$b M. Lynn$0977012 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140612503321 996 $aThe colors of mice$92225728 997 $aUNINA