LEADER 05426nam 2200697Ia 450 001 9910140609703321 005 20200520144314.0 010 $a1-282-54780-1 010 $a9786612547805 010 $a0-470-60012-8 010 $a0-470-60011-X 035 $a(CKB)2670000000014363 035 $a(EBL)510095 035 $a(OCoLC)612342354 035 $a(SSID)ssj0000356931 035 $a(PQKBManifestationID)11275006 035 $a(PQKBTitleCode)TC0000356931 035 $a(PQKBWorkID)10350950 035 $a(PQKB)11226430 035 $a(MiAaPQ)EBC510095 035 $a(Au-PeEL)EBL510095 035 $a(CaPaEBR)ebr10375618 035 $a(CaONFJC)MIL254780 035 $a(PPN)198234155 035 $a(EXLCZ)992670000000014363 100 $a20090923d2010 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBacterial population genetics in infectious disease$b[electronic resource] /$fedited by D. Ashley Robinson, Daniel Falush, Edward J. Feil 210 $aHoboken, N.J. $cJ. Wiley$dc2010 215 $a1 online resource (448 p.) 300 $aDescription based upon print version of record. 311 $a0-470-42474-5 320 $aIncludes bibliographical references and index. 327 $aBacterial Population Genetics in Infectious Disease; Contents; Foreword; Preface; Contributors; Part I: Concepts and Methods in Bacterial Population Genetics; Chapter 1: The Coalescent of Bacterial Populations; 1.1 BACKGROUND AND MOTIVATION; 1.2 POPULATION REPRODUCTION MODELS; 1.3 TIME AND THE EFFECTIVE POPULATION SIZE; 1.4 THE GENEALOGY OF A SAMPLE OF SIZE n; 1.5 FROM COALESCENT TIME TO REAL TIME; 1.6 MUTATIONS; 1.7 DEMOGRAPHY; 1.8 RECOMBINATION AND GENE CONVERSION; 1.9 SUMMARY; REFERENCES; Chapter 2: Linkage, Selection, and the Clonal Complex; 2.1 INTRODUCTION-HISTORICAL OVERVIEW 327 $a2.2 RECOMBINATION, LINKAGE, AND SUBSTRUCTURE 2.3 NEUTRALITY VERSUS SELECTION; 2.4 CLUSTERING TECHNIQUES; REFERENCES; Chapter 33: Sequence-Based Analysis of Bacterial Population Structures; 3.1 INTRODUCTION; 3.2 ALIGNMENTS; 3.3 PHYLOGENETIC METHODS; 3.4 MEASURES OF UNCERTAINTY; 3.5 BEYOND THE TREE MODEL; REFERENCES; Chapter 4: Genetic Recombination and Bacterial Population Structure; 4.1 INTRODUCTION; 4.2 CONSTRAINTS ON LGT; 4.3 INFLUENCES OF LGT ON SEQUENCE ANALYSES; 4.4 THE DETECTION OF INDIVIDUAL LGT EVENTS; 4.5 THE ESTIMATION OF HOMOLOGOUS RECOMBINATION RATES 327 $a4.6 PROPERLY ACCOUNTING FOR LGT DURING SEQUENCE ANALYSES 4.7 QUESTIONS RELATING DIRECTLY TO LGT; REFERENCES; Chapter 5: Statistical Methods for Detecting the Presence of Natural Selection in Bacterial Populations; 5.1 INTRODUCTION; 5.2 NATURAL SELECTION; 5.3 STATISTICAL METHODS FOR DETECTING THE PRESENCE OF NATURAL SELECTION; 5.4 STATISTICAL METHODS FOR BACTERIAL POPULATIONS; 5.5 AN EXAMPLE; 5.6 DISCUSSION AND PERSPECTIVE; REFERENCES; Chapter 6: Demographic Influences on Bacterial Population Structure; 6.1 BACTERIAL POPULATION SIZE; 6.2 MEASURES OF GENETIC DIVERSITY 327 $a6.3 THE CONCEPT OF EFFECTIVE POPULATION SIZE 6.4 INFERRING PAST DEMOGRAPHY FROM GENETIC SEQUENCE DATA; 6.5 POPULATION SUBDIVISION; 6.6 WHAT IS A BACTERIAL POPULATION?; 6.7 CONCLUSION; REFERENCES; Chapter 7: Population Genomics of Bacteria; 7.1 INTRODUCTION; 7.2 CLASSICAL BACTERIAL POPULATION GENETICS; 7.3 THE GENOMICS ERA; 7.4 BACTERIAL POPULATION GENOMICS; 7.5 NEXT-GEN BACTERIAL POPULATION GENOMICS; 7.6 NEXT-GEN GENOMICS TECHNOLOGY; 7.7 NEXT-GEN GENOMIC DATA ANALYSIS; 7.8 CONCLUSIONS/FUTURE PROSPECTS; REFERENCES 327 $aChapter 8: The Use of MLVA and SNP Analysis to Study the Population Genetics of Pathogenic Bacteria 8.1 INTRODUCTION; 8.2 MLVA AND OTHER DNA FRAGMENT-BASED METHODS; 8.3 SNP AND DNA SEQUENCE-BASED METHODS; 8.4 CONCLUSION; REFERENCES; Part II: Population Genetics of Select Bacterial Pathogens; Chapter 9: Population Genetics of Bacillus :Phylogeography of Anthraxin North America; 9.1 INTRODUCTION; 9.2 HISTORY OF ANTHRAX IN NORTH AMERICA; 9.3 THE ANTHRAX DISTRICTS AFTER 1944; 9.4 MOLECULAR GENOTYPING OF B . ANTHRACIS; 9.5 GENOTYPES WITHIN THE ANTHRAX DISTRICTS IN NORTH AMERICA 327 $a9.6 PHYLOGENETIC RESOLUTION WITHIN THE WNA LINEAGE 330 $aThis book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old. Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data. A ""how to"" of bacterial population genetics, which covers an extremely large range of organisms Expanding area of science due to high-throughput genome sequencing of bacterial pathogens Covers both fundamental approaches to analyzing 606 $aPathogenic bacteria 606 $aBacterial genetics 606 $aPopulation genetics 615 0$aPathogenic bacteria. 615 0$aBacterial genetics. 615 0$aPopulation genetics. 676 $a616.07 701 $aRobinson$b D. Ashley$0917275 701 $aFalush$b Daniel$0917276 701 $aFeil$b Edward J$0917277 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140609703321 996 $aBacterial population genetics in infectious disease$92056444 997 $aUNINA