LEADER 05222nam 2200673 a 450 001 9910140551803321 005 20220609154755.0 010 $a1-282-68661-5 010 $a9786612686610 010 $a3-527-63023-6 010 $a3-527-63024-4 035 $a(CKB)2670000000019024 035 $a(EBL)530462 035 $a(OCoLC)630542462 035 $a(SSID)ssj0000420495 035 $a(PQKBManifestationID)11298599 035 $a(PQKBTitleCode)TC0000420495 035 $a(PQKBWorkID)10392251 035 $a(PQKB)10508589 035 $a(MiAaPQ)EBC530462 035 $a(PPN)195044339 035 $a(EXLCZ)992670000000019024 100 $a20100614d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIndustrial biotechnology$b[electronic resource] $esustainable growth and economic success /$fedited by Wim Soetaert and Erick J. Vandamme 210 $aWeinheim $cWiley-VCH$d2010 215 $a1 online resource (523 p.) 300 $aDescription based upon print version of record. 311 $a3-527-31442-3 320 $aIncludes bibliographical references and index. 327 $aIndustrial Biotechnology: Sustainable Growth and Economic Success; Contents; Preface; List of Contributors; The Scope and Impact of Industrial Biotechnology; 1: History of Industrial Biotechnology; 1.1 Early History; 1.2 The Penicillin Story; 1.3 The Coming of the Cephalosporins; 1.4 The Waksman Era; 1.5 Strain Improvement; 1.6 Semi-Synthetic Antibiotics to Combat Resistant Microbes; 1.7 The Primary Metabolites; 1.7.1 Amino Acids; 1.7.2 Nucleotides; 1.7.3 Vitamins; 1.7.4 Organic Acids; 1.7.5 Alcohols; 1.7.6 Polymers 327 $a1.7.7 Specialty Sugars, Sugar Alcohols,L-Sugars, Oligosugars, Novel Extracellular Polysaccharides, Biopigments, Cosmetics Including Fragrants, and Microbial Enzymes for Chiral Synthesis and Other Applications1.8 The Shift from Antibiotics to Pharmacological Agents; 1.8.1 Enzyme Inhibitors; 1.8.2 Immunosuppressants; 1.8.3 Antitumor Agents; 1.8.4 Ergot Alkaloids; 1.8.5 Agricultural Compounds; 1.9 The Biopharmaceutical Revolution; 1.9.1 Human Insulin (Novolin, Humulin); 1.9.2 Erythropoietin (Epogen, Procrit); 1.9.3 Interferons; 1.9.4 Human Growth Hormone (Somatotropin, Somatropin 327 $aHumatrope, Nutropin, Protropin, Somatren, Serostim)1.9.5 Tissue Plasminogen Activator (Activase, Alteplase); 1.9.6 Interleukins; 1.9.7 Factor VIII; 1.9.8 Colony-Stimulating Factors; 1.9.9 Human DNase (Pulmozyme); 1.9.10 Glucocerebrosidas (Cerezyme); 1.9.11 Monoclonal Antibodies; 1.9.12 Additional Biopharmaceuticals; 1.10 Recombinant Hosts; 1.10.1 E. coli; 1.10.2 Yeasts; 1.10.3 Molds; 1.10.4 Insect Cells; 1.10.5 Mammalian Cells; 1.10.6 Transgenic Animals; 1.10.7 Transgenic Plants; 1.11 Enzymes; 1.12 Bioconversions; 1.13 Vaccines; 1.14 Systems Microbiology; References 327 $a2: Industrial Systems Biology2.1 Introduction; 2.2 Industrial Biotechnology; 2.3 Market Drivers for Industrial Biotechnology; 2.4 Industrial Systems Biology; 2.5 Metabolic Models; 2.5.1 Microbial Metabolism-A Historical Perspective; 2.5.2 Genome Sequencing and Functional Genomics; 2.6 Reconstructed Metabolic Network Models; 2.6.1 Introduction; 2.6.2 Genome-Scale Reconstructed Network Process; 2.7 Industrial Systems Biology Case Studies; 2.7.1 A Mature and Developed Industrial Biotechnology Product: Bioethanol 327 $a2.7.2 A Recently Launched and Rapidly Growing Industrial Biotechnology Product: 1,3-Propanediol2.7.3 An In-Development Industrial Biotechnology Product: Succinic Acid; 2.8 Conclusion and Future Perspectives; References; 3: Fermentation Technology; 3.1 Introduction; 3.2 Types of Fermentations; 3.3 Fermentation Process; 3.3.1 Inoculum Generation; 3.3.2 Growth and Product Formation; 3.4 Fermentation Medium Design; 3.5 Sterilization of Air and Fermentation Medium; 3.6 Environmental Factors; 3.7 Fermentation Kinetics; 3.7.1 Batch Fermentation; 3.7.2 Continuous Culture; 3.8 Fermentation Equipment 327 $a3.8.1 Submerged Fermentation 330 $aDescribing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture. 606 $aBiotechnology 606 $aBiotechnology$xSocial aspects 615 0$aBiotechnology. 615 0$aBiotechnology$xSocial aspects. 676 $a660.13 676 $a660.6 686 $aCIT 900f$2stub 686 $aWF 9700$2rvk 686 $aVN 8900$2rvk 701 $aSoetaert$b Wim$0953863 701 $aVandamme$b Erick J.$f1943-$077214 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140551803321 996 $aIndustrial biotechnology$92198440 997 $aUNINA