LEADER 05501nam 2200685 450 001 9910140484103321 005 20170822101630.0 010 $a1-118-85481-0 010 $a1-118-85475-6 010 $a1-118-85477-2 035 $a(CKB)2670000000583823 035 $a(EBL)1873191 035 $a(OCoLC)897448905 035 $a(SSID)ssj0001380985 035 $a(PQKBManifestationID)11803469 035 $a(PQKBTitleCode)TC0001380985 035 $a(PQKBWorkID)11393236 035 $a(PQKB)10549127 035 $a(MiAaPQ)EBC1873191 035 $a(PPN)224476386 035 $a(EXLCZ)992670000000583823 100 $a20140811h20152015 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe chemistry of molecular imaging /$fedited by Nicholas Long, Wing-Tak Wong 210 1$aHoboken, New Jersey :$cWiley,$d[2015] 210 4$dİ2015 215 $a1 online resource (434 p.) 300 $aDescription based upon print version of record. 311 $a1-118-09327-5 311 $a1-322-43948-6 320 $aIncludes bibliographical references and index. 327 $aThe Chemistry of Molecular Imaging; Copyright; Contents; Preface; List of Contributors; Chapter 1 An Introduction to Molecular Imaging; 1.1 Introduction; 1.2 What is Positron Emission Tomography (PET)?; 1.2.1 Basic Principles; 1.2.2 Advantages and Limitations; 1.3 What is Single Photon Emission Computed Tomography (SPECT)?; 1.3.1 Basic Principles; 1.3.2 Advantages and Limitations; 1.4 What is Computed Tomography (CT) or Computed Axial Tomography (CAT)?; 1.4.1 Basic Principles; 1.4.2 Advantages and Limitations; 1.5 What is Magnetic Resonance Imaging (MRI)?; 1.5.1 Basic Principles 327 $a1.5.2 Advantages and Limitations1.6 What is Optical Imaging?; 1.6.1 Basic Principles; 1.6.2 Conventional or Wide-Field Fluorescence Microscopy; 1.6.3 Confocal Microscopy or Confocal Laser Scanning Microscopy; 1.6.4 Advantages and Limitations; 1.7 What is Ultrasound (US)?; 1.7.1 Basic Principles; 1.7.2 Advantages and Limitations; 1.8 Conclusions; References; Chapter 2 Chemical Methodology for Labelling and Bioconjugation; 2.1 Introduction; 2.2 Chemical Methods; 2.2.1 Through Reactions with Aldehydes or Ketones; 2.2.2 Through Reactions with Azides; 2.2.3 Through Reactions with Alkenes 327 $a2.2.4 Cross-Coupling Reactions2.3 Site-Specific Modification of Proteins or Peptides; 2.3.1 N-terminal Cysteine; 2.3.2 Aromatic Residues; 2.3.3 N-terminus of Protein; 2.3.4 C-terminus of Protein; 2.3.5 Introduction of Chemical Tags for Site-Specific Labelling on Peptides or Proteins; 2.4 Conclusions; References; Chapter 3 Recent Developments in the Chemistry of [18F]Fluoride for PET; 3.1 Introduction; 3.2 Fluorine-18: The Starting Material; 3.3 Reactive [18F]Fluoride; 3.4 The Radiofluorination; 3.4.1 Electrophilic Reactions; 3.4.2 Nucleophilic Reactions 327 $a3.5 Labelling of Large Biological Molecules3.5.1 The Prosthetic Group Concept; 3.5.2 Prosthetic Entities with Fluorine-18 Bound to Aluminium, Boron, or Silicon; 3.5.3 Click Chemistry; 3.6 Conclusions; References; Chapter 4 Carbon-11, Nitrogen-13, and Oxygen-15 Chemistry: An Introduction to Chemistry with Short-Lived Radioisotopes; 4.1 Introduction; 4.2 Carbon-11 Chemistry; 4.2.1 Synthesis with [11C]Carbon Dioxide; 4.2.2 [11C]methylation Reactions; 4.2.3 [11C]Phosgene Reactions; 4.2.4 [11C]Cyanation Reactions; 4.2.5 [11C]Carbonylation Reactions; 4.3 Nitrogen-13 Chemistry 327 $a4.3.1 Synthesis of 13N-labelled Amines4.3.2 Enzymatic Synthesis of 13N-labelled Amino Acid; 4.3.3 Synthesis of [13N]cisplatin; 4.3.4 Synthesis of [13N] Carbamates and Ureas; 4.3.5 Other 13N-labelling Reactions; 4.4 Oxygen-15 Chemistry; 4.5 Conclusions; References; Chapter 5 The Chemistry of Inorganic Nuclides (86Y, 68Ga, 64Cu, 89Zr, 124I); 5.1 Introduction: Inorganic Nuclide-Based Radiopharmaceuticals; 5.2 Radiopharmaceutical Design; 5.3 Radiopharmaceutical Stability; 5.4 86Yttrium Radiometal Ion Properties; 5.4.1 Clinical Trials Based on 86Yttrium; 5.4.2 Recent 86Yttrium Work 327 $a5.4.3 Stability of 86Yttrium-Based Radiopharmaceuticals 330 $a"Covering all the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry, The Chemistry of Molecular Engineering focuses primarily on the chemistry of probes and imaging agents, as well as chemical methodology for labelling and bioconjugation. Written by an interdisciplinary team of experts, this book investigates the chemistry of molecular imaging and helps to educate non-chemists already involved in the area of molecular imaging. It addresses all the major modalities and techniques, such as MRI, positron emission tomography, single photon emission computed tomography, ultrasound, and fluorescence/optical imaging"--$cProvided by publisher. 606 $aImaging systems 606 $aImaging systems in medicine 606 $aMolecular probes 615 0$aImaging systems. 615 0$aImaging systems in medicine. 615 0$aMolecular probes. 676 $a616.07 676 $a616.07540154 686 $aTEC015000$2bisacsh 702 $aLong$b Nicholas J.$f1965- 702 $aWong$b Wing-Tak 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140484103321 996 $aThe chemistry of molecular imaging$92006636 997 $aUNINA