LEADER 03728nam 2200601 450 001 9910140279703321 005 20221206182727.0 024 7 $a10.2478/9788376560564 035 $a(CKB)2670000000528798 035 $a(SSID)ssj0001537885 035 $a(PQKBManifestationID)11876286 035 $a(PQKBTitleCode)TC0001537885 035 $a(PQKBWorkID)11522038 035 $a(PQKB)10805877 035 $a(WaSeSS)IndRDA00058672 035 $a(DE-B1597)212029 035 $a(OCoLC)1013942220 035 $a(OCoLC)958034648 035 $a(DE-B1597)9788376560564 035 $a(MiAaPQ)EBC1249831 035 $a(Au-PeEL)EBL1249831 035 $a(CaPaEBR)ebr11055003 035 $a(OCoLC)939262640 035 $a(EXLCZ)992670000000528798 100 $a20150602h20132013 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHistamine H4 receptor $ea novel drug target for immunoregulation and inflammation /$fHolger Stark 210 1$aLondon, England :$cVersita, Versita Limited,$d2013. 210 4$dİ2013 215 $a1 online resource (368 pages) $cillustrations; digital, PDF file(s) 225 0 $aVersita discipline : Chemistry, Life Sciences 300 $aBibliographic Level Mode of Issuance: Monograph 311 0 $a83-7656-055-7 311 0 $a83-7656-056-5 320 $aIncludes bibliographical references and index. 327 $tFront matter --$tContents --$tPreface --$tChapter 1 The histamine H4 receptor story --$tChapter 2 Histamine H4 Receptor Ligands --$tChapter 3 Histamine Metabolism --$tChapter 4 Histamine Receptors and Inflammatory Cells --$tChapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders --$tChapter 6 Histamine in Atopic Disorders: Atopic Dermatitis and Pruritus --$tChapter 7 Non-professional Histamine Producing Cells, Immune Responses and Autoimmunity --$tChapter 8 Histamine in Cancer --$tChapter 9 Non Receptor-mediated Histamine Actions --$tChapter 10 Perspectives in H4R Research and Therapeutic Exploitation --$tList of Figures --$tList of Tables --$tIndex 330 $aH4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed. 606 $aHistamine 610 $aG protein coupled receptors, H4R ligands, Inflammation, Autoimmune Disorders, Pruritus, Asthma, Allergy, Cancer, Drug Development, Drug Target, Clinical Candidates, Biogenic Amin. 615 0$aHistamine. 676 $a612.01575 700 $aStark$b Holger$0802446 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910140279703321 996 $aHistamine H4 receptor$91980461 997 $aUNINA