LEADER 05495nam 2200721Ia 450 001 9910139780703321 005 20230721022747.0 010 $a1-118-21020-4 010 $a1-282-30360-0 010 $a9786612303609 010 $a1-61344-162-2 010 $a0-470-47341-X 010 $a0-470-47340-1 035 $a(CKB)1000000000798936 035 $a(EBL)468968 035 $a(OCoLC)609847673 035 $a(SSID)ssj0000303427 035 $a(PQKBManifestationID)11265549 035 $a(PQKBTitleCode)TC0000303427 035 $a(PQKBWorkID)10275420 035 $a(PQKB)10482496 035 $a(MiAaPQ)EBC468968 035 $a(Au-PeEL)EBL468968 035 $a(CaPaEBR)ebr10342906 035 $a(CaONFJC)MIL230360 035 $a(EXLCZ)991000000000798936 100 $a20090121d2009 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aModern biotechnology$b[electronic resource] $econnecting innovations in microbiology and biochemistry to engineering fundamentals /$fNathan S. Mosier, Michael R. Ladisch 210 $aWiley $cHoboken, NJ$dc2009 215 $a1 online resource (461 p.) 300 $aIncludes index. 311 $a0-470-11485-1 327 $aMODERN BIOTECHNOLOGY; CONTENTS; Preface; Acknowledgments; List of Illustrations; 1 Biotechnology; Introduction; The Directed Manipulation of Genes Distinguishes the New Biotechnology from Prior Biotechnology; Growth of the New Biotechnology Industry Depends on Venture Capital; Submerged Fermentations Are the Industry's Bioprocessing Cornerstone; Oil Prices Affect Parts of the Fermentation Industry; Growth of the Antibiotic/Pharmaceutical Industry; The Existence of Antibiotics Was Recognized in 1877; Penicillin Was the First Antibiotic Suitable for Human Systemic Use 327 $aGenesis of the Antibiotic Industry Other Antibiotics Were Quickly Discovered after the Introduction of Penicillin; Discovery and Scaleup Are Synergistic in the Development of Pharmaceutical Products; Success of the Pharmaceutical Industry in Research, Development, and Engineering Contributed to Rapid Growth but Also Resulted in Challenges; Growth of the Amino Acid/Acidulant Fermentation Industry; Production of Monosodium Glutamate (MSG) via Fermentation; The Impact of Glutamic Acid Bacteria on Monosodium Glutamate Cost Was Dramatic 327 $aAuxotrophic and Regulatory Mutants Enabled Production of Other Amino Acids Prices and Volumes Are Inversely Related; Biochemical Engineers Have a Key Function in All Aspects of the Development Process for Microbial Fermentation; References; Homework Problems; 2 New Biotechnology; Introduction; Growth of the Biopharmaceutical Industry; The Biopharmaceutical Industry Is in the Early Part of Its Life Cycle; Discovery of Type II Restriction Endonucleases Opened a New Era in Biotechnology; The Polymerase Chain Reaction (PCR) Is an Enzyme-Mediated, In Vitro Amplification of DNA 327 $aImpacts of the New Biotechnology on Biopharmaceuticals, Genomics, Plant Biotechnology, and Bioproducts Biotechnology Developments Have Accelerated Biological Research; Drug Discovery Has Benefited from Biotechnology Research Tools; The Fusing of Mouse Spleen Cells with T Cells Facilitated Production of Antibodies; Regulatory Issues Add to the Time Required to Bring a New Product to Market; New Biotechnology Methods Enable Rapid Identification of Genes and Their Protein Products; Genomics Is the Scientific Discipline of Mapping, Sequencing, and Analyzing Genomes 327 $aProducts from the New Plant Biotechnology Are Changing the Structure of Large Companies that Sell Agricultural Chemicals Bioproducts from Genetically Engineered Microorganisms Will Become Economically Important to the Fermentation Industry; References; Homework Problems; 3 Bioproducts and Biofuels; Introduction; Biocatalysis and the Growth of Industrial Enzymes; Glucose Isomerase Catalyzed the Birth of a New Process for Sugar Production from Corn; Identification of a Thermally Stable Glucose Isomerase and an Inexpensive Inducer Was Needed for an Industrial Process 327 $aThe Demand for High-Fructose Corn Syrup (HFCS) Resulted in Large-Scale Use of Immobilized Enzymes and Liquid Chromatography 330 $aBiotechnology introduces students in science, engineering, or technology to the basics of genetic engineering, recombinant organisms, wild-type fermentations, metabolic engineering and microorganisms for the production of small molecule bioproducts. The text includes a brief historical perspective and economic rationale on the impact of regulation on biotechnology production, as well as chapters on biotechnology in relation to metabolic pathways and microbial fermentations, enzymes and enzyme kinetics, metabolism, biological energetics, metabolic pathways, nucleic acids, genetic enginee 606 $aBiotechnology 606 $aChemical engineering 615 0$aBiotechnology. 615 0$aChemical engineering. 676 $a660.6 686 $aBIO 250f$2stub 686 $aCHE 800f$2stub 686 $aCIT 900f$2stub 686 $aWF 9700$2rvk 686 $aWF 9720$2rvk 700 $aMosier$b Nathan S.$f1974-$0879058 701 $aLadisch$b Michael R.$f1950-$0879059 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139780703321 996 $aModern biotechnology$91963071 997 $aUNINA