LEADER 04428oam 2200625Ia 450 001 9910139778503321 005 20231127161934.0 010 $a1-282-38209-8 010 $a9786612382093 010 $a0-470-82316-X 010 $a0-470-82315-1 024 7 $a10.1002/9780470823163 024 8 $a9786612382093 035 $a(CKB)1000000000799079 035 $a(EBL)479834 035 $a(OCoLC)609854660 035 $a(SSID)ssj0000357175 035 $a(PQKBManifestationID)11272671 035 $a(PQKBTitleCode)TC0000357175 035 $a(PQKBWorkID)10352392 035 $a(PQKB)10658786 035 $a(MiAaPQ)EBC479834 035 $a(Au-PeEL)EBL479834 035 $a(CaPaEBR)ebr10325816 035 $a(CaONFJC)MIL238209 035 $a(EXLCZ)991000000000799079 100 $a20081022d2009 uy 0 101 0 $aeng 135 $aurcn#nnn||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiocatalysis for the pharmaceutical industry $ediscovery, development, and manufacturing /$fJunhua Tao, Guoqiang Lin, Andreas Liese 210 $aSingapore ;$aHoboken $cWiley$d2009 215 $a1 online resource (x, 324 pages) $cillustrations 311 0 $a0-470-82314-3 320 $aIncludes bibliographical references and index. 327 $a1. Enzymes and Their Synthetic Applications: An Overview -- 2. Expression Hosts for Enzyme Discovery and Production -- 3. Directed Enzyme Evolution and High-Throughput Screening -- 4. Applications of Reaction Engineering to Industrial Biotransformations -- 5. Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases -- 6. Expanding the Scope of Aldolases as Tools for Organic Synthesis -- 7. Synthetic Applications of Ketoreductases and Alcohol Oxidases -- 327 $a8. Applications of Nitrile Hydratases and Nitrilases -- 9. Biosynthesis of Drug Metabolites -- 10. Application of Whole-Cell Biotransformation in the Pharmaceutical Industry -- 11. Combinatorial Biosynthesis of Pharmaceutical Natural Products -- 12. Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals -- 13. Multimodular Synthases and Supporting Enzymes for Chemical Production -- 14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals. 330 $aBiocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry. 606 $aPharmaceutical biotechnology 606 $aEnzymes$xBiotechnology 615 0$aPharmaceutical biotechnology. 615 0$aEnzymes$xBiotechnology. 676 $a615.19 700 $aTao$b Junhua$0879055 701 $aLin$b Guoqiang$0879056 701 $aLiese$b A$g(Andreas)$0879057 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139778503321 996 $aBiocatalysis for the pharmaceutical industry$91963070 997 $aUNINA