LEADER 05320nam 2200685Ia 450 001 9910139775503321 005 20200520144314.0 010 $a9786612278556 010 $a9781282278554 010 $a128227855X 010 $a9783527628599 010 $a3527628592 010 $a9783527628605 010 $a3527628606 035 $a(CKB)1000000000799204 035 $a(EBL)481355 035 $a(OCoLC)658803703 035 $a(SSID)ssj0000354801 035 $a(PQKBManifestationID)11272633 035 $a(PQKBTitleCode)TC0000354801 035 $a(PQKBWorkID)10315362 035 $a(PQKB)11171105 035 $a(MiAaPQ)EBC481355 035 $a(Perlego)2776214 035 $a(EXLCZ)991000000000799204 100 $a20090129d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aSurface design $eapplications in bioscience and nanotechnology /$fedited by Renate Forch, Holger Schonherr, A. Tobias A. Jenkins 210 $aWeinheim $cWiley-VCH$dc2009 215 $a1 online resource (537 p.) 300 $aDescription based upon print version of record. 311 08$a9783527407897 311 08$a3527407898 320 $aIncludes bibliographical references and index. 327 $aSurface Design: Applications in Bioscience and Nanotechnology; Foreword; Contents; List of Contributors; 1 Tutorial Reviews; 1.1 Coupling Chemistries for the Modification and Functionalization of Surfaces to Create Advanced Biointerfaces; 1.1.1 Introduction; 1.1.2 Surfaces and Self-Assembled Monolayers; 1.1.3 Reactions at Surfaces; 1.1.4 Coupling Chemistries; 1.1.4.1 Covalent Attachment Reactions; 1.1.4.2 Noncovalent Attachment Reactions; References; 1.2 Tutorial Review: Surface Plasmon Resonance-Based Biosensors; 1.2.1 Introduction; 1.2.2 Surface Plasmons 327 $a1.2.3 Optical Excitation of Surface Plasmons1.2.4 Implementation of SPR Biosensors; 1.2.5 Sensitivity of a SPR Biosensor to Biomolecular Binding; 1.2.6 Evaluation of Binding Affinity Constants; 1.2.7 Applications of SPR Biosensors; 1.2.8 Summary; References; 1.3 Tutorial Review: Surface Modification and Adhesion; 1.3.1 Introduction; 1.3.2 Chemical Methods of Adhesion Promotion; 1.3.3 Physicochemical Methods of Surface Modification; 1.3.3.1 Plasma-Assisted Surface Modification; 1.3.4 Analytical Tools to Study Adhesion; 1.3.5 Adhesion Failure - Longevity of Modification; 1.3.6 Summary 327 $aReferences1.4 Tutorial Review: Modern Biological Sensors; 1.4.1 Analytical Concepts in Biosensor Design; 1.4.1.1 Units of Concentration; 1.4.1.2 Sensitivity; 1.4.1.3 Analyte Selectivity; 1.4.1.4 Limit of Detection (LoD); 1.4.2 Signal Amplification; 1.4.2.1 Signal Amplification by Increasing the Effective Analyte Concentration; 1.4.2.2 Signal Amplification by Assay Design; 1.4.2.3 Signal Amplification using High-Sensitivity Instrumentation; 1.4.3 Strategies for Attaching Functional Biomolecules to Surfaces; 1.4.3.1 Biotin-Streptavidin 327 $a1.4.3.2 Direct Covalent Coupling of Biomolecules Using EDC-NHS1.4.3.3 His Tag; 1.4.3.4 Three-Dimensional Sensor Surface Structuring; 1.4.3.5 Brush Surfaces; 1.4.3.6 Specific Orientation of Bound Proteins; 1.4.4 Methods to Prevent Nonspecific Adsorption; 1.4.5 Analyte Recognition; 1.4.6 Overview of some Biosensing Strategies; 1.4.6.1 Bacterial and Viral Sensing; 1.4.6.2 Antibody 'Sandwich' Assay Sensing Platform for Detection of Group B Streptococcus Bacterium; 1.4.6.3 Biosensors for Detecting Viruses: Antibody Recognition and the HIV Test 327 $a1.4.6.4 Biosensors for Detecting Enzymes: Sensors for Human Pregnancy Hormone1.4.6.5 Nucleic-Acid-Based Sensors; 1.4.6.6 Electrochemical Measurement of Blood Glucose; 1.4.7 Summary and Conclusions; References; 2 Functional Thin Film Architecture and Platforms Based on Polymers; 2.1 Controlled Block-Copolymer Thin-Film Architectures; 2.1.1 Introduction; 2.1.2 Results and Discussion; 2.1.2.1 Wetting Layer; 2.1.2.2 Ordering on Planar Substrates; 2.1.2.3 Ordering on Topographically Patterned Substrates; 2.1.3 Conclusions; 2.1.4 Experimental Section; References 327 $a2.2 Stimuli-Responsive Polymer Brushes 330 $aThis carefully selected balance of tutorial-like review chapters and advanced research covers hot topics in the field of biointerfaces, biosensing, nanoparticles at interfaces, and functionalized quantum dots. It also includes chapters arising from non-published work with topics such as surface design and their applications, as well as new developments in analytical tools for materials science and life science. Based on the very close and complementary collaboration of three distinguished leading research groups, this book highlights recent advances in the field ranging from synthesis and 606 $aMaterials$xBiotechnology 606 $aSurfaces (Technology)$xDesign 615 0$aMaterials$xBiotechnology. 615 0$aSurfaces (Technology)$xDesign. 676 $a620.44 701 $aForch$b Renate$0888181 701 $aSchonherr$b Holger$0888182 701 $aJenkins$b A. Tobias A$0888183 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139775503321 996 $aSurface design$91984045 997 $aUNINA