LEADER 02945nam 2200565Ia 450 001 9910139762403321 005 20170816121252.0 010 $a1-282-27906-8 010 $a9786612279065 010 $a0-470-49501-4 010 $a0-470-49500-6 035 $a(CKB)1000000000789931 035 $a(EBL)456205 035 $a(OCoLC)609844905 035 $a(SSID)ssj0000354691 035 $a(PQKBManifestationID)11259192 035 $a(PQKBTitleCode)TC0000354691 035 $a(PQKBWorkID)10314046 035 $a(PQKB)10021992 035 $a(MiAaPQ)EBC456205 035 $a(PPN)14480154X 035 $a(EXLCZ)991000000000789931 100 $a20090223d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aProtein targeting with small molecules$b[electronic resource] $echemical biology techniques and applications /$fedited by Hiroyuki Osada 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2009 215 $a1 online resource (310 p.) 300 $aDescription based upon print version of record. 311 $a0-470-12053-3 320 $aIncludes bibliographical references and index. 327 $aPROTEIN TARGETING WITH SMALL MOLECULES; CONTENTS; Contributors; Preface; 1 Chemical Biology Based on Small Molecule-Protein Interaction; 2 Target Profiling of Small Molecules; 3 Novel Applications of Affinity Beads; 4 Recent Developments and Advances in Chemical Arrays; 5 Use of the Phage Display Technique to Identify the Target Protein; 6 Development of Fluorescent Probes for Small Molecules; 7 Development of Small-Molecule Ligands and Inhibitors; 8 Interaction of a Biological Response Modifier with Proteins; 9 Chemical Biology of Cell Motility Inhibitors 327 $a10 Chemical Biology of Cell Surface Oligosaccharides11 Chemical Genomics Based on Yeast Genetics; 12 Data on Small Molecules and Their Target Proteins; Index 330 $aDiscover the link between the latest chemical biology approaches and novel drug therapies! Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development. This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who a 606 $aProtein binding 606 $aMolecular probes 615 0$aProtein binding. 615 0$aMolecular probes. 676 $a572.633 701 $aOsada$b H$g(Hiroyuki),$f1954-$0882837 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139762403321 996 $aProtein targeting with small molecules$91972240 997 $aUNINA