LEADER 05766nam 2200757Ia 450 001 9910139751303321 005 20230721022629.0 010 $a1-282-27852-5 010 $a9786612278525 010 $a0-470-47597-8 010 $a0-470-47596-X 035 $a(CKB)1000000000790452 035 $a(EBL)455914 035 $a(OCoLC)441892212 035 $a(SSID)ssj0000338203 035 $a(PQKBManifestationID)11292566 035 $a(PQKBTitleCode)TC0000338203 035 $a(PQKBWorkID)10312431 035 $a(PQKB)10694027 035 $a(MiAaPQ)EBC455914 035 $a(Au-PeEL)EBL455914 035 $a(CaPaEBR)ebr10333003 035 $a(CaONFJC)MIL227852 035 $a(EXLCZ)991000000000790452 100 $a20090421d2009 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGlutathione and sulfur amino acids in human health and disease$b[electronic resource] /$fRoberta Masella and Giuseppe Mazza 210 $aHoboken $cWiley$dc2009 215 $a1 online resource (626 p.) 300 $aDescription based upon print version of record. 311 $a0-470-17085-9 327 $aGLUTATHIONE AND SULFUR AMINO ACIDS IN HUMAN HEALTH AND DISEASE; CONTENTS; PREFACE; CONTRIBUTORS; I INTRODUCTION; 1 GLUTATHIONE AND THE SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW; 1.1 Introduction; 1.2 Why Sulfur-Containing Amino Acids?; 1.3 S-Adenosylmethionine, Nature's Wonder Cofactor; 1.4 Glutathione; 1.5 Taurine-the Second Essential Sulfur-Containing Amino Acid?; 1.6 Conclusions; Acknowledgments; References; II CHEMISTRY AND METABOLISM OF GSH AND SULFUR AMINO ACIDS; 2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS: DAILY INTAKE AND REQUIREMENTS; 2.1 Introduction 327 $a2.2 Sulfur Amino Acids (SAA) Content of Dietary Protein2.3 Sulfur Amino Acid Intake; 2.4 Nutritional Requirement for Total Sulfur Amino Acids; 2.5 Conclusions; References; 3 CELLULAR COMPARTMENTALIZATION OF GLUTATHIONE; 3.1 Introduction; 3.2 Glutathione Content in Cells; References; 4 INTESTINAL METABOLISM OF SULFUR AMINO ACIDS; 4.1 Introduction; 4.2 Isotopic Approaches to Study Metabolism; 4.3 Evidence of Gut Sulfur Amino Acid Metabolism; 4.4 Other Key Players in Intestinal Sulfur Amino Acid Metabolism; 4.5 Cysteine in Redox Function and Oxidant Stress in the Gut 327 $a4.6 Pathophysiology of Sulfur Amino Acid Metabolism in the GIT4.7 Conclusions; References; 5 HEPATIC SULFUR AMINO ACID METABOLISM; 5.1 Introduction; 5.2 Dietary Relation between Methionine and Cysteine; 5.3 Metabolic Relation between Hepatic Sulfur Amino Acids, B Vitamins, and Methyl Group Metabolism; 5.4 Regulation of Sulfur Amino Acid Metabolism and Related Metabolic Pathways in the Liver; 5.5 Impact of Physiologic and Nutritional Factors on Sulfur Amino Acid Metabolism; 5.6 Conclusions; References; III ANTIOXIDANT AND DETOXIFICATION ACTIVITIES 327 $a6 GLUTATHIONE AND SULFUR CONTAINING AMINO ACIDS: ANTIOXIDANT AND CONJUGATION ACTIVITIES6.1 Introduction; 6.2 Reactive Oxygen Species and Antioxidants; 6.3 Glutathione Redox Cycle; 6.4 Regulation of GSH and Cysteine Levels; 6.5 Biotransformation; 6.6 ROS-Mediated Cellular Signaling; 6.7 Transcription Regulation of Antioxidant and Conjugation Enzymes; 6.8 Oxidative Stress and Diseases; References; 7 GLUTAREDOXIN AND THIOREDOXIN ENZYME SYSTEMS: CATALYTIC MECHANISMS AND PHYSIOLOGICAL FUNCTIONS; 7.1 Introduction; 7.2 General Characteristics of Glutaredoxins 327 $a7.3 General Characteristics of Thioredoxins7.4 Glutaredoxin Mechanism of Action; 7.5 Thioredoxin Mechanism of Action; 7.6 Control of Grx Expression; 7.7 Control of Trx Expression in Mammalian Systems; 7.8 Cellular Functions of Grx; 7.9 Cellular Functions of Trx; 7.10 Reversible Sulfhydryl Oxidation and Disease; 7.11 Conclusions; References; 8 METHIONINE SULFOXIDE REDUCTASES: A PROTECTIVE SYSTEM AGAINST OXIDATIVE DAMAGE; 8.1 Introduction; 8.2 History of the Msr System; 8.3 MsrA and MsrB Protein Structure and Mechanism of Action; 8.4 Msr Reducing Requirement; 8.5 Other Members of the Msr Family 327 $a8.6 The Msr System: Both a Repair Enzyme and a Scavenger of ROS 330 $aThe complex roles of glutathione and sulfur amino acids in human health Glutathione (?-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease 606 $aGlutathione$xPsychological aspects 606 $aSulfur amino acids$xPsychological aspects 606 $aGlutathione$xTherapeutic use 606 $aSulfur amino acids$xTherapeutic use 606 $aGlutathione$xMetabolism 606 $aSulfur amino acids$xMetabolism 615 0$aGlutathione$xPsychological aspects. 615 0$aSulfur amino acids$xPsychological aspects. 615 0$aGlutathione$xTherapeutic use. 615 0$aSulfur amino acids$xTherapeutic use. 615 0$aGlutathione$xMetabolism. 615 0$aSulfur amino acids$xMetabolism. 676 $a612.015756 676 $a612.3/98 676 $a612.398 700 $aMasella$b Roberta$0887523 701 $aMazza$b G.$f1946-$0887524 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139751303321 996 $aGlutathione and sulfur amino acids in human health and disease$91982646 997 $aUNINA