LEADER 04246nam 2200649 a 450 001 9910139627903321 005 20220408232227.0 010 $a1-283-17565-7 010 $a9786613175656 010 $a1-118-02363-3 010 $a1-118-02364-1 010 $a1-118-02362-5 035 $a(CKB)2550000000041730 035 $a(EBL)697480 035 $a(OCoLC)739118473 035 $a(SSID)ssj0000521990 035 $a(PQKBManifestationID)12187542 035 $a(PQKBTitleCode)TC0000521990 035 $a(PQKBWorkID)10523624 035 $a(PQKB)11628809 035 $a(MiAaPQ)EBC697480 035 $a(Au-PeEL)EBL697480 035 $a(CaPaEBR)ebr10484637 035 $a(CaONFJC)MIL317565 035 $a(PPN)194576183 035 $a(EXLCZ)992550000000041730 100 $a20101116d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDevelopment of vaccines$b[electronic resource] $efrom discovery to clinical testing /$fedited by Manmohan Singh, Indresh K. Srivastava 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2011 215 $a1 online resource (478 p.) 300 $aDescription based upon print version of record. 311 $a0-470-25637-0 320 $aIncludes bibliographical references and index. 327 $aMicrobial vaccines design : the reverse vaccinology approach / Roberto Rosini, Michele A. Barocchi, Rino Rappuoli -- Design and development of recombinant vaccines with viral properties / Gerd Lipowsky, Martin F. Bachmann -- Tools for vaccine design : prediction and validation of highly immunogenic and conserved class II epitopes, and development of epitope-driven vaccines / Anne S. De Groot ... [et al.] -- Virus like-particle vaccines advantages and challenges / Ted M. Ross ... [et al.] -- Design platforms of nanocapsules for human therapeutics or vaccines / Masaaki Kawano ... [et al.] -- Designing immunogens for vaccine development in reference to HIV / Aemro Kassa ... [et al.] -- 327 $aExpression and purification of recombinant proteins for vaccine applications / Carlo Zambonelli, Deeann Martinez-Guzmann, and Indresh K. Srivastava -- DNA vaccines for infectious diesase / Samuel Stepenson, Manmohan Singh, Indresh K. Srivastava -- Developing stable cell lines for the production of vaccine antigens / Xiaotian Zhong ... [et al.] -- Spectroscopy of vaccines / C. Russell Middaugh, Sangeeta B. Joshi -- Biophysical characterization of protein antigens within vaccine formulations / Padima Malyala, Derek O'Hagan, Manmohan Singh -- Structural characteristics predict the stability of HIV / Zohar Biron ... [et al.] -- Selection of optimal adjuvants and product factors that affect vaccine immunogenicity / Wei Wang, Manmohan Singh -- Lyophilization and stabilization of vaccines / James Chesko ... [et al.] -- Effect of buffers and stabilizers on vaccine stability and efficacy / Shireesh P. Apte, Sydney Ugwu -- Selection of final product containers / Luis Baez, Adrian Distler -- From the lab to the clinic : filing a phase I IND for an investigational vaccine / Kenneth G. Surowitz. 330 $aDevelopment of Vaccines: From Discovery to Clinical Testing outlines the critical steps, and analytical tools and techniques, needed to take a vaccine from discovery through a successful clinical trial. Contributions from leading experts in the critical areas of vaccine expression, purification, formulation, pre-clinical testing and regulatory submissions make this book an authoritative collection of issues, challenges and solutions for progressing a biologic drug formulation from its early stage of discovery into its final clinical testing. A section with details and real-life experien 606 $aVaccines 606 $aDrug development 606 $aDrug stability 615 0$aVaccines. 615 0$aDrug development. 615 0$aDrug stability. 676 $a615/.372 701 $aManmohan Singh$f1964 November 8-$01199148 701 $aSrivasta$b Indresh K$0991989 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139627903321 996 $aDevelopment of vaccines$92818608 997 $aUNINA LEADER 01122nam a22002651i 4500 001 991002462369707536 005 20040330165902.0 008 040407s1968 xxc|||||||||||||||||mul 035 $ab12926516-39ule_inst 035 $aARCHE-090612$9ExL 040 $aDip.to Scienze Storiche$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 041 0 $alateng 082 04$a189 100 0 $aTommaso :$cd'Aquino $0290144 245 10$aSt. Thomas Aquinas quaestiones De anima :$ba newly established edition of the Latin text with an introduction and notes /$cedited by James H. Robb 260 $aToronto :$bPontifical institute of mediaeval studies,$c1968 300 $a282 p. ;$c26 cm 600 04$aTommaso :$cd'Aquino $xEdizione critica 700 1 $aRobb, James Harry 907 $a.b12926516$b02-04-14$c16-04-04 912 $a991002462369707536 945 $aLE009 MSM VIII Coll. 13/14$g1$i2009000197176$lle009$o-$pE0.00$q-$rn$so $t0$u0$v0$w0$x0$y.i13499816$z16-04-04 996 $aSt. Thomas Aquinas quaestiones De anima$9304383 997 $aUNISALENTO 998 $ale009$b16-04-04$cm$da $e-$fmul$gxxc$h0$i1