LEADER 06383nam 22015133u 450 001 9910139614403321 005 20240516063333.0 010 $a1-283-20493-2 010 $a9786613204936 010 $a1-4443-4668-7 010 $a1-4443-4666-0 035 $a(CKB)2550000000042700 035 $a(EBL)697793 035 $a(OCoLC)746326590 035 $a(SSID)ssj0000537907 035 $a(PQKBManifestationID)12176511 035 $a(PQKBTitleCode)TC0000537907 035 $a(PQKBWorkID)10567429 035 $a(PQKB)10023227 035 $a(MiAaPQ)EBC697793 035 $a(PPN)20451424X 035 $a(EXLCZ)992550000000042700 100 $a20130418d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aInflammation and Allergy Drug Design 205 $a1st ed. 210 $aChicester $cWiley$d2011 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a1-4443-3014-4 327 $aInflammation and Allergy Drug Design; Contents; Contributors; Preface; Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract; 1: Novel anti-inflammatory drugs based on targeting lung dendritic cells and airway epithelial cells; 2: Role of Th2 cells in the allergic diathesis; 3: Importance of Th17-and Th1-associated responses for the development of asthma; 4: Regulatory T cells; 5: A role for natural killer T-cell subsets in the pathogenesis of various allergic disorders; 6: Regulatory roles of B cells in allergy and inflammation; 7: Mast cells 327 $a8: Eosinophils9: Basophils in inflammation and allergy drug design; 10: Epithelial cells; 11: Fibroblasts; 12: Airway smooth muscle cells; Part II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract; 13: Interleukin 4, interleukin 13, and interleukin 9; 14: Interleukin 3, interleukin 5, and granulocyte-macrophage colony-stimulating factor; 15: Interleukin 15, interleukin 17, and interleukin 25; 16: Thymic stromal lymphopoietin; 17: Interleukin 10; 18: Tumor necrosis factor alpha; 19: Profibrotic and angiogenic factors in asthma; 20: Chemokines 327 $a21: Epithelial growth factorsPart III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract; 22: Prostanoids; 23: Leukotrienes; 24: Proteases in allergy; 25: Toll-like receptors; Index 330 $aThis book educates the reader on the molecular and cellular mechanism of allergic diseases in the respiratory tract covering all aspects, from its immunological basis to its application in drug development. In contrast to other books, this book focuses on well-known and newly-emerging cells, cytokins, and mediators involved in the pathogenesis of allergic diseases in the respiratory tract. In particular, this book emphasises the findings of novel drug targets. This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biolog 606 $aAllergy - Treatment 606 $aAllergy -- Treatment 606 $aAntiallergic agents 606 $aAnti-Allergic Agents 606 $aAntiallergic agents 606 $aAnti-Allergic Agents 606 $aAnti-Inflammatory Agents 606 $aAnti-inflammatory agents 606 $aAnti-inflammatory agents 606 $aDrug Design 606 $aDrug Design 606 $aDrugs - Design 606 $aDrugs -- Design 606 $aHypersensitivity - drug therapy 606 $aHypersensitivity -- drug therapy 606 $aAntiallergic agents$xTreatment 606 $aAllergy$xDesign 606 $aAnti-inflammatory agents 606 $aDrugs 606 $aDrug Discovery 606 $aTherapeutics 606 $aImmune System Diseases 606 $aTherapeutic Uses 606 $aDiseases 606 $aPharmacologic Actions 606 $aInvestigative Techniques 606 $aChemistry, Pharmaceutical 606 $aChemical Actions and Uses 606 $aPharmacology 606 $aChemistry 606 $aBiological Science Disciplines 606 $aNatural Science Disciplines 606 $aDrug Design 606 $aDrug Therapy 606 $aAnti-Allergic Agents 606 $aAnti-Inflammatory Agents 606 $aHypersensitivity 606 $aHealth & Biological Sciences$2HILCC 606 $aPharmacy, Therapeutics, & Pharmacology$2HILCC 615 4$aAllergy - Treatment. 615 4$aAllergy -- Treatment. 615 4$aAntiallergic agents. 615 4$aAnti-Allergic Agents. 615 4$aAntiallergic agents. 615 4$aAnti-Allergic Agents. 615 4$aAnti-Inflammatory Agents. 615 4$aAnti-inflammatory agents. 615 4$aAnti-inflammatory agents. 615 4$aDrug Design. 615 4$aDrug Design. 615 4$aDrugs - Design. 615 4$aDrugs -- Design. 615 4$aHypersensitivity - drug therapy. 615 4$aHypersensitivity -- drug therapy. 615 0$aAntiallergic agents$xTreatment 615 0$aAllergy$xDesign 615 0$aAnti-inflammatory agents 615 0$aDrugs 615 2$aDrug Discovery 615 2$aTherapeutics 615 2$aImmune System Diseases 615 2$aTherapeutic Uses 615 2$aDiseases 615 2$aPharmacologic Actions 615 2$aInvestigative Techniques 615 2$aChemistry, Pharmaceutical 615 2$aChemical Actions and Uses 615 2$aPharmacology 615 2$aChemistry 615 2$aBiological Science Disciplines 615 2$aNatural Science Disciplines 615 2$aDrug Design 615 2$aDrug Therapy 615 2$aAnti-Allergic Agents 615 2$aAnti-Inflammatory Agents 615 2$aHypersensitivity 615 7$aHealth & Biological Sciences 615 7$aPharmacy, Therapeutics, & Pharmacology 676 $a615.7 676 $a615.794 676 $a615/.7 700 $aIzuhara$b K$0927569 701 $aHolgate$b Stephen T$023208 701 $aWills-Karp$b Marsha$0927570 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910139614403321 996 $aInflammation and Allergy Drug Design$92084001 997 $aUNINA