LEADER 05830nam 22010213u 450 001 9910139614103321 005 20220822173102.0 010 $a1-283-20458-4 010 $a9786613204585 010 $a1-119-97940-4 010 $a1-119-97937-4 035 $a(CKB)2550000000042729 035 $a(EBL)697592 035 $a(OCoLC)746598464 035 $a(SSID)ssj0000535620 035 $a(PQKBManifestationID)12234237 035 $a(PQKBTitleCode)TC0000535620 035 $a(PQKBWorkID)10522354 035 $a(PQKB)10434098 035 $a(MiAaPQ)EBC697592 035 $a(EXLCZ)992550000000042729 100 $a20131014d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCurrent and Future Issues in Hemophilia Care /$fedited by Eme?rito-Carlos Rodri?guez-Mercha?n, Leonard A. Valentino 210 $aHoboken $cWiley$d2011 215 $a1 online resource (190 p.) 300 $aDescription based upon print version of record. 311 1 $a0-470-67057-6 327 $aCurrent and Future Issues in Hemophilia Care; Contents; List of Contributors; Preface; Part 1: Introduction; 1 History of Hemophilia; 2 Hemophilia Care in the Modern World; 3 Comprehensive Care Model in Hemophilia; Part 2: General Topics; 4 When Should We Switch from On-Demand to Prophylaxis Regimen?; 5 Prophylaxis in Children; 6 Prophylaxis in Adults with Hemophilia; 7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money?; 8 The Transition of Care for the Young Adult Hemophilia Patient; 9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia 327 $a10 Managing the Mature Person with Hemophilia11 Quality of Life in Hemophilia; Part 3: Inhibitors; 12 Immunology of Inhibitor Development; 13 Epidemiology of Inhibitors; 14 Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A; 15 Prediction of Inhibitors in Severe Hemophilia; 16 Genetic Basis for Inhibitor Development; 17 Non-Genetic Risk Factors for Inhibitor Development; Part 4: Inhibitor Treatment; 18 Immune Tolerance Induction Programs; 19 Prophylaxis in Hemophilia A Patients with Inhibitors; 20 Treatment of Bleeding in FVIII Inhibitor Patients 327 $a21 Discordancy of Bypassing Therapy Part 5: Joint Health and Disease; 22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy; 23 Assessment of Joint Involvement in Hemophilia; 24 Imaging of the Hemophilic Joint; 25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: The Role of Orthopedic Surgery; 26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopedic Surgery; Part 6: New Developments; 27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins 327 $a28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia29 New Developments in Hemophilic Arthropathy; 30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm; 31 Laboratory Assays to Predict Response to Bypassing Agents; 32 Combination/Sequential Use of Bypassing Agents; Index 330 $aAs haemophilia is a life-long condition, continuing supervision by a group of medical personnel is required. In many countries this is provided by comprehensive care haemophilia centres where staff of all specialities concerned with treatment- haematologists, paediatricians, nurses, physiotherapists, orthopaedic surgeons - have specialized knowledge. This new book is a definitive resource on the current aspects and issues around haemophilia. Complications of haemophilia care are well covered in chapters on inhibitors, and musculoskeletal problems, as are all the latest developments in the 606 $aBlood Coagulation Factors 606 $aHemophilia 606 $aHemorrhagic Disorders 606 $aBlood Coagulation Disorders, Inherited 606 $aBiological Factors 606 $aCoagulation Protein Disorders 606 $aBlood Proteins 606 $aBlood Coagulation Disorders 606 $aProteins 606 $aGenetic Diseases, Inborn 606 $aHematologic Diseases 606 $aHemic and Lymphatic Diseases 606 $aAmino Acids, Peptides, and Proteins 606 $aCongenital, Hereditary, and Neonatal Diseases and Abnormalities /$eedited by Eme?rito-Carlos Rodri?guez-Mercha?n, Leonard A. Valentino 606 $aDiseases 606 $aHemophilia A 606 $aBlood Coagulation Factors 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 606 $aHematologic Diseases$2HILCC 615 4$aBlood Coagulation Factors. 615 0$aHemophilia 615 2$aHemorrhagic Disorders 615 2$aBlood Coagulation Disorders, Inherited 615 2$aBiological Factors 615 2$aCoagulation Protein Disorders 615 2$aBlood Proteins 615 2$aBlood Coagulation Disorders 615 2$aProteins 615 2$aGenetic Diseases, Inborn 615 2$aHematologic Diseases 615 2$aHemic and Lymphatic Diseases 615 2$aAmino Acids, Peptides, and Proteins 615 2$aCongenital, Hereditary, and Neonatal Diseases and Abnormalities / 615 2$aDiseases 615 2$aHemophilia A 615 2$aBlood Coagulation Factors 615 7$aMedicine 615 7$aHealth & Biological Sciences 615 7$aHematologic Diseases 676 $a600 676 $a616.1572 702 $aRodriguez-Merchan$b E. C. 702 $aValentino$b Leonard A. 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910139614103321 996 $aCurrent and Future Issues in Hemophilia Care$92904953 997 $aUNINA