LEADER 04716nam 2200697Ia 450 001 9910139611803321 005 20200520144314.0 010 $a1-283-25776-9 010 $a9786613257765 010 $a1-118-06758-4 010 $a1-118-06759-2 010 $a1-118-06752-5 035 $a(CKB)2550000000043383 035 $a(EBL)693185 035 $a(OCoLC)746324265 035 $a(SSID)ssj0000539765 035 $a(PQKBManifestationID)11357057 035 $a(PQKBTitleCode)TC0000539765 035 $a(PQKBWorkID)10571011 035 $a(PQKB)10249447 035 $a(MiAaPQ)EBC693185 035 $a(Au-PeEL)EBL693185 035 $a(CaPaEBR)ebr10510394 035 $a(CaONFJC)MIL325776 035 $a(PPN)243332866 035 $a(EXLCZ)992550000000043383 100 $a20110121d2011 uy 0 101 0 $aeng 135 $aurcn||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aOral bioavailability$b[electronic resource] $ebasic principles, advanced concepts, and applications /$fedited by Ming Hu, Xiaoling Li 210 $aHoboken, NJ $cJohn Wiley & Sons$dc2011 215 $a1 online resource (570 p.) 225 1 $aWiley series in drug discovery and development 300 $aDescription based upon print version of record. 311 $a0-470-26099-8 320 $aIncludes bibliographical references. 327 $aORAL BIOAVAILABILITY; CONTENTS; Foreword; Preface; Contributors; 1 Barriers to Oral Bioavailability-An Overview; 2 Physicochemical Characterization of Pharmaceutical Solids; 3 Solubility of Pharmaceutical Solids; 4 In Vitro Dissolution of Pharmaceutical Solids; 5 Biological and Physiological Features of the Gastrointestinal Tract Relevant to Oral Drug Absorption; 6 Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways; 7 In Vitro-In Vivo Correlations of Pharmaceutical Dosage Forms; 8 Drug Metabolism in Gastrointestinal Tract 327 $a9 Efflux of Drugs via Transporters-The Antiabsorption Pathway 10 Liver Drug Metabolism; 11 Protein Binding of Drugs; 12 Urinary Excretion of Drugs and Drug Reabsorption; 13 Pharmacokinetic Behaviors of Orally Administered Drugs; 14 Effects of Food on Drug Absorption; 15 Drug-Drug Interactions and Drug-Dietary Chemical Interactions; 16 Anatomical and Physiological Factors Affecting Oral Drug Bioavailability in Rats, Dogs, and Humans; 17 Amino Acid Drug Transporters; 18 Drug Transporters and Their Role in Absorption and Disposition of Peptides and Peptide-Based Pharmaceuticals 327 $a19 Organic Anion and Cation Drug Transporters 20 Gastric Retentive Drug Delivery Systems; 21 Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems; 22 Prodrug Strategies to Enhance Oral Drug Absorption; 23 Oral Delivery of Protein/Peptide Therapeutics; 24 ABC Transporters in Intestinal and Liver Efflux; 25 Interplay Between Efflux Transporters and Metabolic Enzymes; 26 Regulatory Considerations in Metabolism- and Transporter-Based Drug Interactions; 27 Caco-2 Cell Culture Model for Oral Drug Absorption; 28 MDCK Cells and Other Cell-Culture Models of Oral Drug Absorption 327 $a29 Intestinal Perfusion Methods for Oral Drug Absorptions 30 Liver Perfusion and Primary Hepatocytes for Studying Drug Metabolism and Metabolite Excretion; 31 In vivo Methods for Oral Bioavailability Studies; 32 Determination of Regulation of Drug-Metabolizing Enzymes and Transporters; 33 Computational and Pharmacoinformatic Approaches to Oral Bioavailability Prediction; Index 330 $aUnderstand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the a 410 0$aWiley series in drug discovery and development. 606 $aDrugs$xBioavailability 606 $aDrug development 606 $aIntestinal absorption 615 0$aDrugs$xBioavailability. 615 0$aDrug development. 615 0$aIntestinal absorption. 676 $a615/.19 701 $aHu$b Ming$cPh. D.$0883616 701 $aLi$b Xiaoling$f1957-$0505392 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139611803321 996 $aOral bioavailability$91973599 997 $aUNINA