LEADER 06613nam 22011293u 450 001 9910139596403321 005 20230725051155.0 010 $a1-283-23945-0 010 $a9786613239457 010 $a0-470-93995-8 010 $a0-470-93994-X 035 $a(CKB)2550000000046148 035 $a(EBL)697477 035 $a(OCoLC)748937811 035 $a(SSID)ssj0000536955 035 $a(PQKBManifestationID)12231342 035 $a(PQKBTitleCode)TC0000536955 035 $a(PQKBWorkID)10565046 035 $a(PQKB)11732087 035 $a(MiAaPQ)EBC697477 035 $a(EXLCZ)992550000000046148 100 $a20131014d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFundamental Neuropathology for Pathologists and Toxicologists$b[electronic resource] $ePrinciples and Techniques 210 $aHoboken $cWiley$d2011 215 $a1 online resource (644 p.) 300 $aDescription based upon print version of record. 311 $a0-470-22733-8 327 $aFundamental Neuropathology for Pathologists and Toxicologists: Principles and Techniques; CONTENTS; CONTRIBUTORS; FOREWORD; PREFACE; INTRODUCTION; PART 1: FUNDAMENTALS OF NEUROBIOLOGY; 1 Fundamental Neuropathology for Pathologists and Toxicologists: An Introduction; 2 Functional Neuroanatomy; 3 Atlas of Comparative Neuroanatomy; 4 Principles of Comparative and Correlative Neurodevelopment and Their Implications for Developmental Neurotoxicity; 5 Localizing Neuropathological Lesions Using Neurological Findings; 6 Behavioral Model Systems for Evaluating Neuropathology 327 $a7 Cognitive Assessments in Nonhuman Primates8 Impact of Aging on Brain Structure and Function in Rodents and Canines; 9 Fundamentals of Neurotoxicity Detection; PART 2: TOXICOLOGIC NEUROPATHOLOGY: METHODOLOGY; 10 Practical Neuropathology of the Rat and Other Species; 11 Fluoro-Jade Dyes: Fluorochromes for the Histochemical Localization of Degenerating Neurons; 12 Histological Markers of Neurotoxicity (Nonfluorescent); 13 Common Histological Artifacts in Nervous System Tissues; 14 High-Definition Microscopic Analysis of the Nervous System 327 $a15 Stereological Solutions for Common Quantitative Endpoints in Neurotoxicology16 Anatomy and Processing of Peripheral Nerve Tissues; 17 Pathology Methods in Nonclinical Neurotoxicity Studies: Evaluation of Muscle; 18 In Vivo Imaging Applications for the Nervous System in Animal Models; 19 Cerebrospinal Fluid Analysis in Toxicological Neuropathology; 20 Molecular Techniques in Toxicological Neuropathology; PART 3: TOXICOLOGICAL NEUROPATHOLOGY: CURRENT PRACTICES; 21 Evaluation of the Adult Nervous System in Preclinical Studies 327 $a22 Pathology Methods in Nonclinical Neurotoxicity Studies: The Developing Central Nervous System23 Neuropathological Analysis of the Peripheral Nervous System; 24 Toxicological Pathology of the Retina and Optic Nerve; 25 Toxicological Neuropathology of the Ear; 26 Neuropathology of the Olfactory System; PART 4: APPLIED TOXICOLOGICAL NEUROPATHOLOGY; 27 Spinal Delivery and Assessment of Drug Safety; 28 Diagnostic Neuropathology; 29 Toxicological Neuropathology in Medical Practice; 30 Toxicological Neuropathology in Veterinary Practice 327 $a31 Regulatory Considerations in Toxicological Neuropathology32 The Neuropathology Report and the Neuropathology Peer Review Report; 33 Preparation of Personnel for Performing Neuropathological Assessment; 34 Regulatory Guide to the Histopathological Assessment of Neurotoxicity Studies; 35 Toxicological Neuropathology: The Next Two Decades; APPENDIXES: READY REFERENCES OF NEUROBIOLOGY KNOWLEDGE; Appendix 1: Neural Cell Markers of Potential Utility for Toxicological Neuropathology Applications; Appendix 2: Text-Based Neuroanatomic Atlases for Toxicological Neuropathology Studies 327 $aAppendix 3: Text-Based Neurobiology References for Toxicological Neuropathologists 330 $aThis book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology - including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports). 606 $aModels, Animal 606 $aNervous system -- Diseases 606 $aNeurotoxicity Syndromes -- diagnosis 606 $aNeurotoxicity Syndromes -- physiopathology 606 $aNeurotoxicology 606 $aNeurotoxicology$xDiseases 606 $aNervous system 606 $aInvestigative Techniques 606 $aPoisoning 606 $aAnatomy 606 $aNoxae 606 $aNervous System Diseases 606 $aSubstance-Related Disorders 606 $aDiseases 606 $aToxic Actions 606 $aChemical Actions and Uses 606 $aNeurotoxicity Syndromes 606 $aDiagnosis 606 $aNeurotoxins 606 $aNervous System 606 $aModels, Animal 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 606 $aNeurology$2HILCC 615 4$aModels, Animal. 615 4$aNervous system -- Diseases. 615 4$aNeurotoxicity Syndromes -- diagnosis. 615 4$aNeurotoxicity Syndromes -- physiopathology. 615 4$aNeurotoxicology. 615 0$aNeurotoxicology$xDiseases 615 0$aNervous system 615 2$aInvestigative Techniques 615 2$aPoisoning 615 2$aAnatomy 615 2$aNoxae 615 2$aNervous System Diseases 615 2$aSubstance-Related Disorders 615 2$aDiseases 615 2$aToxic Actions 615 2$aChemical Actions and Uses 615 2$aNeurotoxicity Syndromes 615 2$aDiagnosis 615 2$aNeurotoxins 615 2$aNervous System 615 2$aModels, Animal 615 7$aMedicine 615 7$aHealth & Biological Sciences 615 7$aNeurology 676 $a616.8071 700 $aBolon$b Brad$0970645 701 $aButt$b Mark$0970646 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910139596403321 996 $aFundamental Neuropathology for Pathologists and Toxicologists$92206211 997 $aUNINA