LEADER 05473nam 22007453u 450 001 9910139569303321 005 20250709214131.0 010 $a9786613306791 010 $a9781283306799 010 $a1283306794 010 $a9781119953647 010 $a1119953642 010 $a9781119953609 010 $a111995360X 035 $a(CKB)2550000000057774 035 $a(EBL)822569 035 $a(SSID)ssj0000580958 035 $a(PQKBManifestationID)12221401 035 $a(PQKBTitleCode)TC0000580958 035 $a(PQKBWorkID)10524645 035 $a(PQKB)11368003 035 $a(MiAaPQ)EBC822569 035 $a(PPN)170266036 035 $a(OCoLC)768204566 035 $a(FR-PaCSA)88808436 035 $a(FRCYB88808436)88808436 035 $a(EXLCZ)992550000000057774 100 $a20131223d2011|||| u|| | 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aIntroduction to Pharmaceutical Chemical Analysis 210 $aHoboken $cWiley$d2011 215 $a1 online resource (512 p.) 300 $aDescription based upon print version of record. 311 08$a9780470661222 311 08$a0470661224 311 08$a9780470661215 311 08$a0470661216 327 $aIntroduction to Pharmaceutical Chemical Analysis; Table of Contents; Preface; 1 Introduction to Pharmaceutical Analysis; 1.1 Applications and Definitions; 1.2 The Life of Medicines; 1.3 The Quality of Medical Products; 1.4 Summary; 2 International Pharmacopoeias, Regulations and Guidelines; 2.1 Overview of Legislation; 2.2 Legislation and Regulations for Industrial Production; 2.3 Life Time of Drugs and Drug Substances; 2.4 Pharmacopoeias; 2.5 International Harmonization; 2.5.1 International Conference on Harmonization; 2.5.2 Pharmacopoeial Discussion Group 327 $a2.6 Legislation and Regulations for Pharmacy Production2.7 Summary; 3 Fundamental Chemical Properties, Buffers and pH; 3.1 pH and pKa; 3.2 Partition; 3.3 Stereochemistry; 3.4 Stability Testing; 3.5 Summary; 4 Fundamentals of Pharmaceutical Analysis; 4.1 What is a Pharmaceutical (Chemical) Analysis?; 4.2 How to Specify Quantities and Concentrations?; 4.3 Basic Laboratory Equipment; 4.3.1 The Analytical Balance; 4.3.2 Pipettes; 4.3.3 Volumetric Flasks; 4.3.4 Burettes; 4.4 How to Make Solutions and Dilutions; 4.5 Calibration of Analytical Methods; 4.6 Errors, Accuracy, and Precision 327 $a4.6.1 Systematic and Random Errors4.6.2 Accuracy and Precision; 4.7 Statistics; 4.7.1 Mean Value and Standard Deviation; 4.7.2 Confidence Intervals; 4.7.3 Comparison of Means with a t-Test; 4.7.4 Q-Test to Reject Outliers; 4.7.5 Linear Regression with the Method of Least Squares; 4.7.6 How to Present an Analytical Result; 4.8 Some Words and Concepts; 4.8.1 Analysis and Determination; 4.8.2 Sample Replicates and Measuring Replicates; 4.8.3 Interference; 4.8.4 Blind Samples; 5 Titrimetric Methods; 5.1 Introduction; 5.2 Acid-Base Titrations; 5.3 Acid-Base Titrations in Non-Aqueous Media 327 $a5.4 Redox Titrations5.5 Other Principles of Titration; 5.6 Summary; 6 Introduction to Spectroscopic Methods; 6.1 Electromagnetic Radiation; 6.2 Molecules and Electromagnetic Radiation; 6.3 Atoms and Electromagnetic Radiation; 6.4 Summary; 7 UV Spectrophotometry; 7.1 Principle of Quantitative Determination; 7.2 Principle of Identification; 7.3 Which Substances Have Strong UV Absorbance?; 7.4 Instrumentation; 7.5 Practical Work and Method Development; 7.6 Areas of Usage and Performance; 7.7 System Testing; 7.8 Summary; 8 IR Spectrophotometry; 8.1 IR Spectrophotometry; 8.2 Instrumentation 327 $a8.3 Scope8.4 Instrument Calibration; 8.5 NIR Spectrophotometry; 8.6 Applications; 8.7 Summary; 9 Atomic Spectrometry; 9.1 Atomic Absorption Spectrometry; 9.2 Instrumentation; 9.3 Applications and Performance; 9.4 Practical Work and Method Development; 9.5 Atomic Emission Spectrometry; 9.6 Instrumentation; 9.7 Summary; 10 Chromatography; 10.1 General Principles; 10.2 Retention; 10.3 Column Efficiency; 10.4 Selectivity; 10.5 Peak Symmetry; 10.6 Resolution; 10.7 Chromatographic Techniques; 10.8 Summary; 11 Chromatographic Separation Principles; 11.1 General Introduction 327 $a11.2 Normal Phase Chromatography 330 $aThis textbook is the first to present a systematic introduction to chemical analysis of pharmaceutical raw materials, finished pharmaceutical products, and of drugs in biological fluids, which are carried out in pharmaceutical laboratories worldwide. In addition, this textbook teaches the fundamentals of all the major analytical techniques used in the pharmaceutical laboratory, and teaches the international pharmacopoeias and guidelines of importance for the field. It is primarily intended for the pharmacy student, to teach the requirements in "analytical chemistry" for the 5 years pharmacy 606 $aDrugs$xAnalysis 606 $aPharmaceutical chemistry 615 0$aDrugs$xAnalysis. 615 0$aPharmaceutical chemistry. 676 $a615.19 686 $a499.33$2njb/09 686 $aQV 55$2njb/09 686 $a615.1/9$2njb/09 701 $aPedersen-Bjergaard$b Stig$0900989 701 $aRasmussen$b Knut$0900990 801 0$bAU-PeEL 801 1$bAU-PeEL 801 2$bAU-PeEL 906 $aBOOK 912 $a9910139569303321 996 $aIntroduction to Pharmaceutical Chemical Analysis$92013872 997 $aUNINA