LEADER 05344nam 2200673Ia 450 001 9910139564303321 005 20230725053820.0 010 $a1-283-33323-6 010 $a9786613333230 010 $a1-119-97270-1 010 $a1-119-99893-X 010 $a1-119-99846-8 035 $a(CKB)2550000000063588 035 $a(EBL)697586 035 $a(OCoLC)773799268 035 $a(SSID)ssj0000539474 035 $a(PQKBManifestationID)11357046 035 $a(PQKBTitleCode)TC0000539474 035 $a(PQKBWorkID)10568342 035 $a(PQKB)11406157 035 $a(OCoLC)768230372 035 $a(MiAaPQ)EBC697586 035 $a(EXLCZ)992550000000063588 100 $a20110518d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNeuroimaging in addiction$b[electronic resource] /$fBryon Adinoff and Elliot Stein 210 $aChichester, West Sussex $cJohn Wiley & Sons$d2011 215 $a1 online resource (373 p.) 300 $aDescription based upon print version of record. 311 $a0-470-66014-7 320 $aIncludes bibliographical references and index. 327 $aNeuroimagingin Addiction; Contents; Foreword; List of Contributors; 1 Introduction; 2 An Integrated Framework for Human Neuroimaging Studies of Addiction from a Preclinical Perspective; 2.1 Introduction; 2.2 A Conceptual Framework for Understanding Drug Addiction Based on Preclinical Observations; 2.3 Neuropharmacological Considerations; 2.4 Neuropathology of Chronic Drug Abuse; 2.5 Impulsivity: An Endophenotype for Drug Addiction; 2.6 Compulsivity: Craving versus Drug-Seeking; 2.7 Summary; References 327 $a3 Structural and Functional Neuroimaging Methods: Applications to Substance Abuse and Addiction3.1 Introduction; 3.2 MRI Based Imaging Tools and their Application to Drug Abuse Research; 3.3 Molecular Imaging with PET and SPECT; 3.4 Summary and Peek into the Future; References; 4 Functional Neuroimaging of the Acute Effects of Drugs of Abuse; 4.1 Introduction; 4.2 Fundamental Neuronal Systems Related to Abuse Liability in Humans; 4.3 Psychostimulants; 4.4 Alcohol; 4.5 Cannabis and the Cannabinoids; 4.6 Opioids; 4.7 Conclusions and Future Directions; References; 5 Reward Processing 327 $a5.1 Introduction5.2 Neurotransmitter Systems Implicated in Reward Processing; 5.3 Neurotransmitter Systems Involved in Drug-Related Reward Processing; 5.4 Alterations in the Mesostriatal System in Addiction; 5.5 Summary and Outlook; 5.6 Acknowledgments; References; 6 A Neuroimaging Approach to the Study of Craving; 6.1 A Neuroimaging Approach to the Study of Craving; 6.2 Neural Response During Cue-Elicited Craving; 6.3 Associations between Neural and Subjective Response During Cue-Elicited Craving; 6.4 Modulators of Neural Response During Cue-Elicited Craving 327 $a6.5 Effects of Intervention on the Neural Response During Cue-Elicited Craving6.6 Summary and Integration of Findings; 6.7 Conclusions; References; 7 Impulsivity and Addiction; 7.1 Introduction; 7.2 Impulsivity as Reward versus Control; 7.3 The Neurobiology of Impulsivity; 7.4 Impulsivity and Risk for Developing a Drug Use Disorder; 7.5 Impulsivity in Current Users; 7.6 Impulsivity, Abstinence, and Relapse; 7.7 Conclusion; References; 8 Cognitive Disruptions in Drug Addiction: a Focus on the Prefrontal Cortex; 8.1 Introduction; 8.2 Attention; 8.3 Working Memory; 8.4 Decision-Making 327 $a8.5 Pre-Morbid Vulnerabilities8.6 Other Brain Regions; 8.7 Limitations Across All Studies; 8.8 Treatment Implications; 8.9 General Summary and Conclusions; 8.10 Acknowledgments; References; 9 Neural Mechanisms of Stress and Addiction; 9.1 Stress and Addiction; 9.2 Neural Circuits of Stress Regulation; 9.3 Dysfunction in the Neural Circuits Underlying Stress and Addiction; 9.4 Interplay of Gene, Stress, and Drug Intake; 9.5 Acknowledgments; References; 10 Anatomical and Neurochemical Evidence of Neurotoxic Changes in Psychostimulant Abuse and Dependence; 10.1 Introduction 327 $a10.2 Characteristics of Psychostimulants 330 $aNeuroimaging in Addiction presents an up-to-date, comprehensive review of the functional and structural imaging human studies that have greatly advanced our understanding of this complex disorder. Approaching addiction from a conceptual rather than a substance-specific perspective, this book integrates broad neuropsychological constructs that consider addiction as a neuroplastic process with genetic, developmental, and substance-induced contributions. The internationally recognized contributors to this volume are leaders in clinical imaging with expertise that spans the addiction spec 606 $aBrain$xEffect of drugs on 606 $aBrain$xRadiography 606 $aCompulsive behavior$xMagnetic resonance imaging 615 0$aBrain$xEffect of drugs on. 615 0$aBrain$xRadiography. 615 0$aCompulsive behavior$xMagnetic resonance imaging. 676 $a616.8 676 $a616.8047572 700 $aAdinoff$b Bryon$0886285 701 $aStein$b Elliot$0886286 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139564303321 996 $aNeuroimaging in addiction$91978946 997 $aUNINA