LEADER 05683nam 2200709Ia 450 001 9910139558903321 005 20230803075350.0 010 $a1-283-33226-4 010 $a9786613332264 010 $a1-118-13538-5 010 $a1-118-13539-3 010 $a1-118-13536-9 035 $a(CKB)2550000000064527 035 $a(EBL)818454 035 $a(OCoLC)768230312 035 $a(SSID)ssj0000538448 035 $a(PQKBManifestationID)11331452 035 $a(PQKBTitleCode)TC0000538448 035 $a(PQKBWorkID)10559164 035 $a(PQKB)10142768 035 $a(MiAaPQ)EBC818454 035 $a(Au-PeEL)EBL818454 035 $a(CaPaEBR)ebr10510539 035 $a(CaONFJC)MIL333226 035 $a(EXLCZ)992550000000064527 100 $a20110611d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLC-NMR and other hyphenated NMR techniques$b[electronic resource] $eoverview and applications /$fMaria Victoria Silva Elipe 210 1$aHoboken, NJ :$cWiley,$dc2012. 215 $a1 online resource (240 p.) 225 1 $aTHEi Wiley ebooks 300 $aDescription based upon print version of record. 311 $a0-470-54834-7 320 $aIncludes bibliographical references and index. 327 $aLC-NMR and Other Hyphenated NMR Techniques: Overview and Applications; Contents; Preface; Abbreviations, Symbols, and Units; 1. Basic Concepts of NMR Spectroscopy; 1.1 Introduction; 1.2 Basic Knowledge Regarding the Physics of NMR Spectroscopy; 1.3 Basic Parameters for NMR Interpretation; 1.3.1 Chemical Shift; 1.3.2 Spin-Spin Coupling Constants; 1.3.3 Spin Systems; 1.3.4 Signal Intensities; 1.3.5 Bond Correlations; 1.3.6 Spatial Correlations; 1.3.7 Other Topics; 1.4 Conclusions; References; 2. Historical Development of NMR and LC-NMR; 2.1 Introduction; 2.2 Historical Development of NMR 327 $a2.3 Historical Development of LC-NMR2.4 Historical Development of Other Analytical Techniques Hyphenated with NMR; 2.5 Current Trends; References; 3. Basic Technical Aspects and Operation of LC-NMR and LC-MS-NMR; 3.1 Introduction; 3.2 Technical Considerations Regarding LC-NMR; 3.2.1 Solvent Compatibility; 3.2.2 Solvent Suppression; 3.2.3 NMR Flow Cell; 3.2.4 LC-NMR Sensitivity; 3.3 Technical Considerations Regarding LC-MS-NMR; 3.3.1 Deuterated Solvents; 3.4 Modes of Operation of LC-NMR; 3.4.1 On-Flow Mode; 3.4.2 Stop-Flow Mode; 3.4.3 Time-Sliced Mode; 3.4.4 Loop Collection Mode 327 $a3.5 Modes of Operation of LC-MS-NMR3.5.1 On-Flow Mode; 3.5.2 Stop-Flow Mode; 3.6 Other Modes of Operation; 3.7 Challenging Considerations; 3.7.1 Air Bubbles; 3.7.2 Carryover with and Without an Autosampler; 3.7.3 Sample Solubility and Precipitation; 3.7.4 Flow Cell and System Cleaning; 3.7.5 Flow Rate and Magnetic Susceptibility; 3.7.6 Quantitation; 3.8 Conclusions; References; 4. Applications of LC-NMR; 4.1 Introduction; 4.2 Applications of LC-NMR; 4.2.1 Natural Products; 4.2.2 Drug Metabolism; 4.2.3 Drug Discovery; 4.2.4 Impurity Characterization; 4.2.5 Degradation Products 327 $a4.2.6 Food Analysis4.2.7 Polymers; 4.2.8 Metabolomics and Metabonomics; 4.2.9 Isomers, Tautomers, and Chiral Compounds; 4.2.10 Others Areas; 4.3 Conclusions and Future Trends; References; 5. Applications of LC-MS-NMR; 5.1 Introduction; 5.2 Applications of LC-MS-NMR; 5.2.1 Natural Products; 5.2.2 Drug Metabolism; 5.2.3 Drug Discovery and Development; 5.2.4 Metabolomics and Metabonomics; 5.2.5 Others Areas; 5.3 Conclusions and Future Trends; References; 6. Hyphenation of NMR with Other Analytical Separation Techniques; 6.1 Introduction; 6.2 GC-NMR; 6.3 GPC-NMR; 6.4 SEC-NMR; 6.5 SFC-NMR 327 $a6.6 SFE-NMR6.7 CE-NMR; 6.8 CEC-NMR; 6.9 CZE-NMR; 6.10 cITP-NMR; 6.11 CapLC-NMR; 6.12 SPE-NMR; 6.13 SPE-MS-NMR; 6.14 Conclusions and Future Trends; References; 7. Special Topics and Applications Related to LC-NMR; 7.1 Introduction; 7.2 Off-Line Versus Online NMR for Structural Elucidation; 7.2.1 Cases Solved Off-Line; 7.2.2 Cases Solved Online; 7.3 Analysis of Chiral Molecules by NMR; 7.3.1 Classical Approach: Off-Line; 7.3.2 Nonclassical Approach: Online; 7.4 Monitoring Chemical Reactions In Situ; 7.4.1 Classical Approach: Off-Line; 7.4.2 Nonclassical Approach: Online 327 $a7.5 Analysis of Mixtures Off-Line, Online, and by Other NMR Methodologies 330 $aThis practical guide provides a basic overview of the pros and cons of NMR spectroscopy as both a hyphenated and non-hyphenated technique. The book begins with a description of basic NMR concepts for the structural elucidation of organic compounds and then details the historical development of NMR and hyphenated NMR in the structural elucidation world, followed by applications of hyphenated NMR as LC-NMR and LC-MS-NMR in industry and academia. It also contains updated information on the latest advancements and applications of LC-NMR in such areas as degradation products, drug metabolism, food 410 0$aTHEi Wiley ebooks. 606 $aNuclear magnetic resonance spectroscopy$xIndustrial applications 606 $aOrganic compounds$xAnalysis 606 $aDrug development 615 0$aNuclear magnetic resonance spectroscopy$xIndustrial applications. 615 0$aOrganic compounds$xAnalysis. 615 0$aDrug development. 676 $a543/.66 686 $aSCI078000$2bisacsh 700 $aSilva Elipe$b Maria V.$f1963-$0996116 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139558903321 996 $aLC-NMR and other hyphenated NMR techniques$92282766 997 $aUNINA