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010   $a9786613082015
010   $a0-470-94029-8
010   $a0-470-94028-X
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100   $a20100809d2011      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aPlatelet proteomics $eprinciples, analysis, and applications /$fedited by Angel Garcia, Yotis Senis
205   $a1st ed.
210   $aHoboken, NJ $cJohn Wiley & Sons$dc2011
215   $a1 online resource (425 p.)
225 1 $aWiley-Interscience series on mass spectrometry
300   $aDescription based upon print version of record.
311   $a0-470-46337-6 
320   $aIncludes bibliographical references and index.
327   $aPLATELET PROTEOMICS; CONTENTS; Contributors; Foreword; Preface; Acronyms; PART I GENERAL OVERVIEW: PLATELETS, SAMPLE PREPARATION, AND MASS SPECTROMETRY-BASED PROTEOMICS; 1 Platelets and Their Role in Thrombotic and Cardiovascular Disease: The Impact of Proteomic Analysis; 2 Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research; 3 Sample Preparation Variables in Platelet Proteomics for Biomarker Research; PART II ANALYSIS OF THE PLATELET PROTEOME: GLOBAL APPROACHES AND SUBPROTEOMES
327   $a4 Two-Dimensional Gel Electrophoresis: Basic Principles and Application to Platelet Signaling Studies5 The Platelet Membrane Proteome; 6 Proteomics of Platelet Granules, Organelles, and Releasate; 7 The Platelet Microparticle Proteome; 8 N-Terminal Combined Fractional Diagonal Chromatographic (COFRADIC) Analysis of the Human Platelet Proteome; PART III INTEGRATED "OMICS" AND APPLICATION TO DISEASE; 9 Serial Analysis of Gene Expression (SAGE) For Studying the Platelet and Megakaryocyte Transcriptome
327   $a10 The Application of Microarray Analysis and Its Integration with Proteomics for Study of Platelet-Associated Disorders11 Platelet Functional Genomics; 12 Systems Biology to Study Platelet-Related Bleeding Disorders; 13 Platelet Proteomics in Transfusion Medicine; 14 Cardiovascular Proteomics; Index
330   $aThe purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics.  This chapter shows potential applications for platelet proteomics not yet carried out.  It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separat
410  0$aWiley-Interscience series on mass spectrometry.
606   $aBlood platelets
606   $aProteomics
615  0$aBlood platelets.
615  0$aProteomics.
676   $a612.1/17
701   $aGarcia$b Angel$f1968-$0970643
701   $aSenis$b Yotis A.$f1970-$0970644
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910139450803321
996   $aPlatelet proteomics$92206210
997   $aUNINA